Enzymatic Degradation of Monolayer for Poly(lactide) Revealed by Real-Time Atomic Force Microscopy: Effects of Stereochemical Structure, Molecular Weight, and Molecular Branches on Hydrolysis Rates

2008 ◽  
Vol 9 (8) ◽  
pp. 2180-2185 ◽  
Author(s):  
Keiji Numata ◽  
Anna Finne-Wistrand ◽  
Ann-Christine Albertsson ◽  
Yoshiharu Doi ◽  
Hideki Abe
Keyword(s):  
Molecular Weight ◽  
Atomic Force Microscopy ◽  
Real Time ◽  
Enzymatic Degradation ◽  
Stereochemical Structure ◽  
Force Microscopy ◽  
Atomic Force ◽  
Hydrolysis Rates

scholarly journals Atomic force microscopy reveals the role of vascular smooth muscle cell elasticity in hypertension

2020 ◽  
Author(s):  
Yi Zhu
Keyword(s):  
Atomic Force Microscopy ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Real Time ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Research Subjects ◽  
Force Microscopy ◽  
Atomic Force

AbstractThe vascular smooth muscle cell (VSMC) mechanical properties not only provide intrinsic cellular functions, but also influence many vascular and circulation functions in physiology. In this report, the VSMCs of thoracic aorta from 16 week age Wistar-Kyoto normotensive rats (WKY) and spontaneously hypertensive rats (SHR) were used as research subjects to reveal hypertension mechanism at a single cell level using atomic force microscopy (AFM). The apparent elastic modulus was significantly increased in VSMCs from SHRs compared to those from WKYs. Treatment with cytochalasin D (CD), ML7, Y27632 and lysophosphatidic acid (LPA) modulated VSMC stiffness of WKYs and SHRs. A spectral analysis approach was applied to further investigate the time-dependent change in VSMC elasticity of WKYs and SHRs. This report demonstrated the efficacy of real-time analysis of VSMC elasticity by AFM nano-indentation, and revealed real-time functional differences in biomechanical characteristics of VSMCs with drug treatments.

Sensor Referenced Real-Time Videolization of Atomic Force Microscopy for Nanomanipulations

2008 ◽  
Vol 13 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Lianqing Liu ◽  
Yilun Luo ◽  
Ning Xi ◽  
Yuechao Wang ◽  
Jiangbo Zhang ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Real Time ◽  
Force Microscopy ◽  
Atomic Force
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