Multidentate Block-Copolymer-Stabilized Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Enhanced Colloidal Stability for Magnetic Resonance Imaging

2014 ◽  
Vol 15 (6) ◽  
pp. 2146-2156 ◽  
Author(s):  
Nicky Chan ◽  
Myriam Laprise-Pelletier ◽  
Pascale Chevallier ◽  
Andrea Bianchi ◽  
Marc-André Fortin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Block Copolymer ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide

Enhanced encapsulation of superparamagnetic Fe3O4 in acidic core-containing micelles for magnetic resonance imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (130) ◽  
pp. 107938-107948 ◽  
Author(s):  
Depannita Biswas ◽  
Puzhen Li ◽  
Dapeng Liu ◽  
Jung Kwon Oh
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Block Copolymer ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Loading Level

Block copolymer-based magnetic nanoassembled structures with acidic cores exhibiting enhanced loading level of superparamagnetic iron oxide nanoparticles, thus having great potential for theranostics based on MRI.

MR and Iron Magnetic Nanoparticles. Imaging Opportunities in Preclinical and Translational Research

2008 ◽  
Vol 94 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Carlo Emanuele Neumaier ◽  
Gabriella Baio ◽  
Silvano Ferrini ◽  
Giorgio Corte ◽  
Antonio Daga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide

Ultrasmall superparamagnetic iron oxide nanoparticles and magnetic resonance imaging provide a non-invasive method to detect and label tumor cells. These nanoparticles exhibit unique properties of superparamagnetism and can be utilized as excellent probes for magnetic resonance imaging. Most work has been performed using a magnetic resonance scanner with high field strength up to 7 T. Ultrasmall superparamagnetic iron oxide nanoparticles may represent a suitable tool for labeling molecular probes that target specific tumor-associated markers for in vitro and in vivo detection by magnetic resonance imaging. In our study, we demonstrated that magnetic resonance imaging at 1.5 T allows the detection of ultrasmall superparamagnetic iron oxide nanoparticle conjugated antibody specifically bound to human tumor cells in vitro and in vivo, and that the magnetic resonance signal intensity correlates with the concentration of ultrasmall superparamagnetic iron oxide nanoparticle antibody used and with the antigen density at the cell surface. The experiments were performed using two different means of targeting: direct and indirect magnetic tumor targeting. The imaging of tumor antigens using immunospecific contrast agents is a rapidly evolving field, which can potentially aid in early disease detection, monitoring of treatment efficacy, and drug development. Cell labeling by iron oxide nanoparticles has emerged as a potentially powerful tool to monitor trafficking of a large number of cells in the cell therapy field. We also studied the labeling of natural killer cells with iron nanoparticles to a level that would allow the detection of their signal intensity with a clinical magnetic resonance scanner at 1.5 T. Magnetic resonance imaging and iron magnetic nanoparticles are able to increase the accuracy and the specificity of imaging and represent new imaging opportunities in preclinical and translational research.

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