Monodispersed Brush-Like Conjugated Polyelectrolyte Nanoparticles with Efficient and Visualized SiRNA Delivery for Gene Silencing

2013 ◽  
Vol 14 (10) ◽  
pp. 3643-3652 ◽  
Author(s):  
Rongcui Jiang ◽  
Xiaomei Lu ◽  
Minhua Yang ◽  
Weixing Deng ◽  
Quli Fan ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Sirna Delivery ◽  
Conjugated Polyelectrolyte

Visible quantum-dot-based targeted siRNA delivery for HIF-1α gene silencing

2014 ◽  
Vol 24 (5) ◽  
pp. 445-451 ◽  
Author(s):  
HongYan Zhu ◽  
JingPing Zhu ◽  
AiMei Xie ◽  
Yong Lin ◽  
BeiBei Zhang ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Gene Silencing ◽  
Sirna Delivery

scholarly journals In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation

2014 ◽  
Vol 196 ◽  
pp. 355-362 ◽  
Author(s):  
Vikas Hegde ◽  
Robyn P. Hickerson ◽  
Sitheswaran Nainamalai ◽  
Paul A. Campbell ◽  
Frances J.D. Smith ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Sirna Delivery ◽  
Topical Formulation ◽  
Non Invasive

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

2014 ◽  
Vol 50 (58) ◽  
pp. 7806-7809 ◽  
Author(s):  
Hangxiang Wang ◽  
Wei Chen ◽  
Haiyang Xie ◽  
Xuyong Wei ◽  
Shengyong Yin ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gene Silencing ◽  
Delivery System ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Single Step ◽  
Chimeric Peptide ◽  
Supramolecular Nanoparticles ◽  
Sirna Delivery System

A practical and tumor cell-specific siRNA delivery system was developedviasingle-step self-assembly of an arginine-rich chimeric peptide with siRNA.

scholarly journals WRAP-based nanoparticles for siRNA delivery: a SAR study and a comparison with lipid-based transfection reagents

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Karidia Konate ◽  
Emilie Josse ◽  
Milana Tasic ◽  
Karima Redjatti ◽  
Gudrun Aldrian ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Gene Silencing ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Sirna Delivery ◽  
Cell Penetrating Peptides ◽  
Sirna Transfection ◽  
Arginine Residues ◽  
Sar Study

AbstractRecently, we designed novel amphipathic cell-penetrating peptides, called WRAP, able to transfer efficiently siRNA molecules into cells. In order to gain more information about the relationship between amino acid composition, nanoparticle formation and cellular internalization of these peptides composed of only three amino acids (leucine, arginine and tryptophan), we performed a structure–activity relationship (SAR) study. First, we compared our WRAP1 and WRAP5 peptides with the C6M1 peptide also composed of the same three amino acids and showing similar behaviors in siRNA transfection. Afterwards, to further define the main determinants in the WRAP activity, we synthesized 13 new WRAP analogues harboring different modifications like the number and location of leucine and arginine residues, the relative location of tryptophan residues, as well as the role of the α-helix formation upon proline insertions within the native WRAP sequence. After having compared the ability of these peptides to form peptide-based nanoparticles (PBNs) using different biophysical methods and to induce a targeted gene silencing in cells, we established the main sequential requirements of the amino acid composition of the WRAP peptide. In addition, upon measuring the WRAP-based siRNA transfection ability into cells compared to several non-peptide transfection agents available on the markets, we confirmed that WRAP peptides induced an equivalent level of targeted gene silencing but in most of the cases with lower cell toxicity as clearly shown in clonogenic assays.

scholarly journals Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types

2017 ◽  
Vol 18 (11) ◽  
pp. 3753-3765 ◽  
Author(s):  
Dominic W. Malcolm ◽  
Margaret A. T. Freeberg ◽  
Yuchen Wang ◽  
Kenneth R. Sims ◽  
Hani A. Awad ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Diblock Copolymer ◽  
Sirna Delivery ◽  
Cell Types ◽  
Efficient Gene

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

2018 ◽  
Vol 48 ◽  
pp. 96-105 ◽  
Author(s):  
Hannaneh monirinasab ◽  
Hamed Asadi ◽  
Kobra Rostamizadeh ◽  
Abdolreza Esmaeilzadeh ◽  
Malihe Khodaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Two-Photon-Induced Charge-Variable Conjugated Polyelectrolyte Brushes for Effective Gene Silencing

2019 ◽  
Vol 2 (4) ◽  
pp. 1676-1685 ◽  
Author(s):  
Hui Zhao ◽  
Haojie Tao ◽  
Wenbo Hu ◽  
Xiaofei Miao ◽  
Yufu Tang ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Conjugated Polyelectrolyte ◽  
Polyelectrolyte Brushes ◽  
Two Photon ◽  
Induced Charge

F127/Calcium phosphate hybrid nanoparticles: a promising vector for improving siRNA delivery and gene silencing

2013 ◽  
Vol 24 (15) ◽  
pp. 1757-1766 ◽  
Author(s):  
Liubin Qin ◽  
Ying Sun ◽  
Peifeng Liu ◽  
Qi Wang ◽  
Baosan Han ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Gene Silencing ◽  
Sirna Delivery ◽  
Hybrid Nanoparticles
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