Self-Healing Mussel-Inspired Multi-pH-Responsive Hydrogels

2013 ◽  
Vol 14 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Marie Krogsgaard ◽  
Manja A. Behrens ◽  
Jan Skov Pedersen ◽  
Henrik Birkedal
Keyword(s):  
Self Healing ◽  
Ph Responsive ◽  
Responsive Hydrogels

scholarly journals Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

2020 ◽  
Vol 11 (17) ◽  
pp. 4516-4524 ◽  
Author(s):  
Chen Wang ◽  
Amit Fischer ◽  
Avner Ehrlich ◽  
Yaakov Nahmias ◽  
Itamar Willner
Keyword(s):  
Controlled Release ◽  
Shape Memory ◽  
Self Healing ◽  
Ph Responsive ◽  
Responsive Hydrogels

Biocatalytic control over the stiffness of pH-responsive hydrogels is applied to develop shape-memory, self-healing and controlled release matrices.

scholarly journals Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jiahui He ◽  
Zixi Zhang ◽  
Yutong Yang ◽  
Fenggang Ren ◽  
Jipeng Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endoscopic Treatment ◽  
Healing Process ◽  
Gelation Time ◽  
Type I ◽  
Self Healing ◽  
Ph Responsive ◽  
Gastric Hemorrhage ◽  
Wound Model ◽  
Arterial Bleeding

AbstractEndoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogels showed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, α-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.

scholarly journals Bio-Inspired pH Responsive Hydrogels for Programmed Activation of Electrochemical Storage Systems in Biology

2015 ◽  
Vol 108 (2) ◽  
pp. 485a ◽  
Author(s):  
Nateé Johnson ◽  
Young Jo Kim ◽  
Hangjun Dingh ◽  
Philip LeDuc ◽  
Christopher Bettinger
Keyword(s):  
Storage Systems ◽  
Ph Responsive ◽  
Electrochemical Storage ◽  
Responsive Hydrogels

scholarly journals An Experiment to Introduce pH-responsive Hydrogels for Controlled Drug Delivery: Mechanical Testing

2020 ◽  
Author(s):  
Stephanie Farrell ◽  
Jennifer Vernengo ◽  
Madina Yermagambetova ◽  
Peter Schwalbenberg
Keyword(s):  
Drug Delivery ◽  
Mechanical Testing ◽  
Controlled Drug Delivery ◽  
Ph Responsive ◽  
Responsive Hydrogels

pH-Responsive Self-Healing Anticorrosion Coating Based on a Lignin Microsphere Encapsulating Inhibitor

2020 ◽  
Vol 59 (7) ◽  
pp. 2657-2666 ◽  
Author(s):  
Zhiyou Tan ◽  
Shan Wang ◽  
Zhuorong Hu ◽  
Weilong Chen ◽  
Zhencai Qu ◽  
...  
Keyword(s):  
Self Healing ◽  
Ph Responsive ◽  
Anticorrosion Coating

Light- and pH-responsive self-healing hydrogel

2019 ◽  
Vol 54 (13) ◽  
pp. 9983-9994 ◽  
Author(s):  
Meng Yang ◽  
Linlin Wang ◽  
Yongbin Cheng ◽  
Ke Ma ◽  
Xinran Wei ◽  
...  
Keyword(s):  
Self Healing ◽  
Ph Responsive
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