Supramolecular Organization in Self-Assembly of Chromatin and Cationic Lipid Bilayers is Controlled by Membrane Charge Density

2012 ◽  
Vol 13 (12) ◽  
pp. 4146-4157 ◽  
Author(s):  
Nikolay V. Berezhnoy ◽  
Dan Lundberg ◽  
Nikolay Korolev ◽  
Chenning Lu ◽  
Jiang Yan ◽  
...  
Keyword(s):  
Charge Density ◽  
Lipid Bilayers ◽  
Self Assembly ◽  
Cationic Lipid ◽  
Supramolecular Organization ◽  
Membrane Charge

DNA Condensation at Freestanding Cationic Lipid Bilayers

2010 ◽  
Vol 104 (14) ◽  
Author(s):  
C. Herold ◽  
P. Schwille ◽  
E. P. Petrov
Keyword(s):  
Lipid Bilayers ◽  
Cationic Lipid ◽  
Dna Condensation

scholarly journals Self-assembly mechanism based on charge density topological interaction energies

2017 ◽  
Vol 29 (3) ◽  
pp. 703-713 ◽  
Author(s):  
Błażej Dziuk ◽  
Christopher G. Gianopoulos ◽  
Krzysztof Ejsmont ◽  
Bartosz Zarychta
Keyword(s):  
Charge Density ◽  
Self Assembly ◽  
Interaction Energies ◽  
Assembly Mechanism ◽  
Topological Interaction

scholarly journals Anomalous Thermo-osmotic Conversion Performance of Ionic Covalent-Organic-Framework Membranes in Response to Charge Variations

2022 ◽  
Author(s):  
Qi Sun ◽  
Weipeng Xian ◽  
Xiuhui Zuo ◽  
Changjia Zhu ◽  
Qing Guo ◽  
...  
Keyword(s):  
Charge Density ◽  
Energy Conversion ◽  
Energy Demand ◽  
High Performance ◽  
Critical Factor ◽  
Energy Conversion Efficiency ◽  
Nanoporous Membranes ◽  
Power Extraction ◽  
Membrane Charge ◽  
Salinity Difference

Abstract The development of efficient thermo-osmotic energy conversion devices has fascinated scientists and engineers for several decades in terms of satisfying the growing energy demand. The fabrication of ionic membranes with a high charge population is known to be a critical factor in the design of high-performance power generators for achieving high permselectivity and, consequently, high power extraction efficiency. Herein, we experimentally demonstrated that the thermo-osmotic energy conversion efficiency was improved by increasing the membrane charge density; however, this enhancement occurred only within a narrow window and subsequently exhibited a plateau over a threshold density. The complex interplay between pore−pore interactions and fluid structuration for ion transport across the upscaled nanoporous membranes helped explain the obtained results with the aid of numerical simulations. Consequently, the power generation efficiency of the multipore membrane deteriorated, deviating considerably from the case of simple linear extrapolation of the behavior of the single-pore counterparts. A plateau in the output electric power was observed at a moderate charge density, affording a value of 210 W m−2 at a 50-fold salinity difference with a temperature gradient of 40 K. This study has far-reaching implications for discerning an optimal range of membrane charge populations for augmenting the energy extraction, rather than intuitively focusing on achieving high densities.

scholarly journals Modification of a Single Atom Affects the Physical Properties of Double Fluorinated Fmoc-Phe Derivatives

2021 ◽  
Vol 22 (17) ◽  
pp. 9634
Author(s):  
Moran Aviv ◽  
Dana Cohen-Gerassi ◽  
Asuka A. Orr ◽  
Rajkumar Misra ◽  
Zohar A. Arnon ◽  
...  
Keyword(s):  
Amino Acid ◽  
Physical Properties ◽  
Self Assembly ◽  
Deep Understanding ◽  
Building Blocks ◽  
The Self ◽  
Single Atom ◽  
Supramolecular Organization ◽  
Assembly Process ◽  
Wide Range

Supramolecular hydrogels formed by the self-assembly of amino-acid based gelators are receiving increasing attention from the fields of biomedicine and material science. Self-assembled systems exhibit well-ordered functional architectures and unique physicochemical properties. However, the control over the kinetics and mechanical properties of the end-products remains puzzling. A minimal alteration of the chemical environment could cause a significant impact. In this context, we report the effects of modifying the position of a single atom on the properties and kinetics of the self-assembly process. A combination of experimental and computational methods, used to investigate double-fluorinated Fmoc-Phe derivatives, Fmoc-3,4F-Phe and Fmoc-3,5F-Phe, reveals the unique effects of modifying the position of a single fluorine on the self-assembly process, and the physical properties of the product. The presence of significant physical and morphological differences between the two derivatives was verified by molecular-dynamics simulations. Analysis of the spontaneous phase-transition of both building blocks, as well as crystal X-ray diffraction to determine the molecular structure of Fmoc-3,4F-Phe, are in good agreement with known changes in the Phe fluorination pattern and highlight the effect of a single atom position on the self-assembly process. These findings prove that fluorination is an effective strategy to influence supramolecular organization on the nanoscale. Moreover, we believe that a deep understanding of the self-assembly process may provide fundamental insights that will facilitate the development of optimal amino-acid-based low-molecular-weight hydrogelators for a wide range of applications.

scholarly journals Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

RSC Advances ◽  
2018 ◽  
Vol 8 (57) ◽  
pp. 32823-32831 ◽  
Author(s):  
Sengan Megarajan ◽  
Siva Bala Subramaniyan ◽  
Sureshan Muthuswamy ◽  
Savarimuthu Philip Anthony ◽  
Jothi Arunachalam ◽  
...  
Keyword(s):  
Self Assembly ◽  
Phase Behaviour ◽  
Supramolecular Organization

Self assembly of N-acyltris(hydroxymethyl)aminomethane into interdigitized vesicles.

Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer

2020 ◽  
Vol 56 (52) ◽  
pp. 7092-7095
Author(s):  
Hiroto Furukawa ◽  
Hiroshi Inaba ◽  
Fumihito Inoue ◽  
Yoshihiro Sasaki ◽  
Kazunari Akiyoshi ◽  
...  
Keyword(s):  
Lipid Bilayer ◽  
Self Assembly ◽  
Cationic Lipid ◽  
Viral Capsid ◽  
Viral Capsids ◽  
Simple Strategy ◽  
Self Assembled

We demonstrated a simple strategy for constructing enveloped artificial viral capsids by self-assembly of anionic artificial viral capsid and lipid bilayer containing cationic lipid.

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