Biodegradable Amphiphilic Copolymer Containing Nucleobase: Synthesis, Self-Assembly in Aqueous Solutions, and Potential Use in Controlled Drug Delivery

2012 ◽  
Vol 13 (9) ◽  
pp. 3004-3012 ◽  
Author(s):  
Huihui Kuang ◽  
Suhong Wu ◽  
Zhigang Xie ◽  
Fanbo Meng ◽  
Xiabin Jing ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Amphiphilic Copolymer ◽  
Potential Use

Microfluidic self-assembly of polymeric nanoparticles with tunable compactness for controlled drug delivery

Polymer ◽  
2013 ◽  
Vol 54 (18) ◽  
pp. 4972-4979 ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Hamid Mirzadeh ◽  
Faramarz Afshar Taromi ◽  
Bo Nyström
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Delivery

scholarly journals Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

2019 ◽  
Vol 15 ◽  
pp. 1925-1932 ◽  
Author(s):  
Yang Bai ◽  
Cai-ping Liu ◽  
Di Chen ◽  
Long-hai Zhuo ◽  
Huai-tian Bu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Transition Process ◽  
Hydrodynamic Diameter ◽  
Cancer Cell Proliferation ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
Amphiphilic Molecules ◽  
Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery

2005 ◽  
Vol 288-289 ◽  
pp. 117-120 ◽  
Author(s):  
Jun Li ◽  
Xu Li ◽  
Xiping Ni ◽  
Xin Wang ◽  
Hongzhe Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Special Importance ◽  
New Class ◽  
Polymeric Biomaterials ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Bioactive Agents ◽  
Aqueous Conditions

Of many polymeric biomaterials, hydrogels are of special importance because of their favorable biocompatibility and pertinence in delivering delicate bioactive agents such as proteins. Physical hydrogels have attracted much attention for controlled drug delivery because of the mild and aqueous conditions involved in trapping bioactive agents. This paper reviews our recent progress on developing a new class of physical hydrogels based on the supramolecular self-assembly between cyclodextrins and bioabsorbable poly(ethylene oxide) (PEO) or its copolymers. Being thixotropic, the hydrogels can be injected through needles and applied as injectable drug delivery systems. The properties of the hydrogels also can be fine-tuned with triblock copolymers where PEO segments flank hydrophobic or biodegradable segments in the middle.

scholarly journals Drug induced micelle-to-vesicle transition in aqueous solutions of cationic surfactants

RSC Advances ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. 3861-3869 ◽  
Author(s):  
Zuber S. Vaid ◽  
Arvind Kumar ◽  
Omar A. El Seoud ◽  
Naved I. Malek
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Aqueous Solutions ◽  
Cationic Surfactants ◽  
Cetyltrimethylammonium Bromide ◽  
Diclofenac Sodium ◽  
Drug Induced ◽  
P Solubilization ◽  
Micellar Aggregates ◽  
Potential Use

Solubilization of the drug diclofenac sodium (DS) in micellar aggregates of ionic liquid-based surfactants and cetyltrimethylammonium bromide at 25 °C induces changes to worm-like micelles and vesicles, with potential use in drug delivery.

scholarly journals Self-assembly of cholesterol end-capped polymer micelles for controlled drug delivery

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ming Gao ◽  
Yifeng Yang ◽  
Andreas Bergfel ◽  
Lanli Huang ◽  
Li Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Polymer Micelles

scholarly journals Cyclodextrins in Parkinson’s Disease

Biomolecules ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 3 ◽  
Author(s):  
Marisa C. F. Barros ◽  
Ana C. F. Ribeiro ◽  
Miguel A. Esteso
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Aqueous Solutions ◽  
Molar Volume ◽  
Partial Molar Volume ◽  
Diffusion Coefficients ◽  
Dopaminergic Neurons ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems

: Parkinson’s disease is a movement disorder characterized by a progressive degeneration of dopaminergic neurons that has been object of study by the scientific community through the last decades. However, nowadays there is still no treatment to cure it, although there are drugs available, with limited efficacy, to relieve the symptoms or replenish the cells with dopamine to supply the lack of dopaminergic neurons. This work was structured in two parts. In the first one, binary aqueous solutions of L-dopa and cyclodextrins were studied. In the second part, ternary aqueous solutions of L-dopa were studied with each of the selected cyclodextrins. In all cases, thermodynamic properties (density, partial molar volume and thermodynamic transfer functions for temperatures between 294.15 ± 0.01 K and 312.15 ± 0.01 K) and transport properties (mutual diffusion coefficients, viscosity, transfer viscosity at 298.15 ± 0.01 K and 310.15 ± 0.01 K) were studied. Using theoretical models to adjust the experimental data obtained for the diffusion coefficients and for the apparent molar volumes, in the ternary aqueous solutions, it was possible to estimate the values to the L-dopa-cyclodextrin association constant. For the aqueous ternary solutes, the partial molar volume of transfer of levodopa in the presence of the cyclodextrins, the partial molar expansibility at infinite dilution and from this, the Hepler constant, were determined. Also, the values of Gibbs free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) were determined. From the obtained information, it was possible to characterize the molecular interactions, as well as to identify some structural characteristics of the controlled drug delivery systems under study and to estimate the influence of the cyclodextrin substituent groups, and, also, the temperature effect in the interaction levodopa-cyclodextrin. It is our intent to attain information about the mechanism of possible new systems for controlled drug delivery systems, throughout an alternative perspective, which could allow to increase its effectiveness in the Parkinson’s treatment.

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