Blood Clearance and Biodistribution of Polymer Brush-Afforded Silica Particles Prepared by Surface-Initiated Living Radical Polymerization

2012 ◽  
Vol 13 (3) ◽  
pp. 927-936 ◽  
Author(s):  
Kohji Ohno ◽  
Tatsuki Akashi ◽  
Yoshinobu Tsujii ◽  
Masaya Yamamoto ◽  
Yasuhiko Tabata
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Silica Particles ◽  
Living Radical Polymerization ◽  
Blood Clearance

Essential Factors to Make Excellent Biocompatibility of Phospholipid Polymer Materials

2010 ◽  
Vol 76 ◽  
pp. 1-9 ◽  
Author(s):  
Kazuhiko Ishihara ◽  
Yuuki Inoue
Keyword(s):  
Radical Polymerization ◽  
Blood Compatibility ◽  
Membrane Surface ◽  
Polymer Brush ◽  
Living Radical Polymerization ◽  
Polymer Chains ◽  
Polymer Materials ◽  
Biomaterial Surface ◽  
Phospholipid Polymer ◽  
Living Organisms

Recently, much attention has been attracted to bio/blood compatible materials to suppress undesirable biological reactions that determine the fate of living organisms and materials. A phospholipid polymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, which is designed by inspiration of cell membrane surface structure, is the most promising polymer biomaterial with excellent bio/blood compatibility. Progress in living radical polymerization method initiated from the surface enables preparation of a dense polymer chains on the surface, which is called as a polymer brush. The polymer brush structure has narrow molecular weight distribution and controlled chain length. So, it is ideal surface to clarify the interactions between the biomolecules and biomaterial surface that has never done. In these regards, the poly(MPC) brush surfaces are expected to be a novel class of biomaterials, and have been extensively studied its unusual properties. In this review, surface-initiated living radical polymerization of MPC and the characteristics of the poly(MPC) brush surfaces are summarized from a viewpoint of biomaterials science.

Fabrication of Complex Three-Dimensional Polymer Brush Nanostructures through Light-Mediated Living Radical Polymerization

2013 ◽  
Vol 52 (27) ◽  
pp. 6844-6848 ◽  
Author(s):  
Justin E. Poelma ◽  
Brett P. Fors ◽  
Gregory F. Meyers ◽  
John W. Kramer ◽  
Craig J. Hawker
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Three Dimensional ◽  
Living Radical Polymerization

Fabrication of Complex Three-Dimensional Polymer Brush Nanostructures through Light-Mediated Living Radical Polymerization

2013 ◽  
Vol 125 (27) ◽  
pp. 6982-6986 ◽  
Author(s):  
Justin E. Poelma ◽  
Brett P. Fors ◽  
Gregory F. Meyers ◽  
John W. Kramer ◽  
Craig J. Hawker
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Three Dimensional ◽  
Living Radical Polymerization

Fabrication of High-Density Polymer Brush on Polymer Substrate by Surface-Initiated Living Radical Polymerization

2005 ◽  
Vol 38 (11) ◽  
pp. 4604-4610 ◽  
Author(s):  
Chiaki Yoshikawa ◽  
Atsushi Goto ◽  
Yoshinobu Tsujii ◽  
Takeshi Fukuda ◽  
Kazuya Yamamoto ◽  
...  
Keyword(s):  
Radical Polymerization ◽  
Polymer Brush ◽  
Living Radical Polymerization ◽  
High Density ◽  
Polymer Substrate
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