Intrinsically Fluorescent PAMAM Dendrimer as Gene Carrier and Nanoprobe for Nucleic Acids Delivery: Bioimaging and Transfection Study

2011 ◽  
Vol 12 (12) ◽  
pp. 4283-4290 ◽  
Author(s):  
Ya-Ju Tsai ◽  
Chao-Chin Hu ◽  
Chih-Chien Chu ◽  
Toyoko, Imae
Keyword(s):  
Nucleic Acids ◽  
Pamam Dendrimer ◽  
Gene Carrier ◽  
Nucleic Acids Delivery ◽  
Transfection Study

Exosome as a Natural Gene Delivery Vector for Cancer Treatment

2020 ◽  
Vol 20 (11) ◽  
pp. 821-830
Author(s):  
Prasad Pofali ◽  
Adrita Mondal ◽  
Vaishali Londhe
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Intestinal Barrier ◽  
Gene Carrier ◽  
Gene Delivery Vector ◽  
Delivery Vector

Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size 40-100 nm secreted from multivesicular bodies into the extracellular environment by most of the cell types in-vivo and in-vitro. As a natural nanocarrier, exosomes are immunologically inert, biocompatible, and can cross biological barriers like the blood-brain barrier, intestinal barrier, and placental barrier. Objective: This review focusses on the role of exosome as a carrier to efficiently deliver a gene for cancer treatment and diagnosis. The methods for loading of nucleic acids onto the exosomes, advantages of exosomes as a smart intercellular shuttle for gene delivery and therapeutic applications as a gene delivery vector for siRNA, miRNA and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and also the limitations of exosomes as a gene carrier are all reviewed in this article. Methods: Mostly, electroporation and chemical transfection are used to prepare gene loaded exosomes. Results: Exosome-mediated delivery is highly promising and advantageous in comparison to the current delivery methods for systemic gene therapy. Targeted exosomes, loaded with therapeutic nucleic acids, can efficiently promote the reduction of tumor proliferation without any adverse effects. Conclusion: In the near future, exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer.

scholarly journals Mesoporous Silica Nanoparticles Based Antigens and Nucleic Acids Delivery: A Review

1970 ◽  
Vol 8 (2) ◽  
pp. 50-57
Author(s):  
Jemal Dilebo
Keyword(s):  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Mesoporous Structure ◽  
Nucleic Acid Delivery ◽  
Hollow Core ◽  
Small Molecule Drugs ◽  
Cell Accumulation ◽  
Nucleic Acids Delivery

Mesoporous silica nanoparticles (MSN) have been explored for the delivery of small molecule drugs, antigens, and nucleic acids because of their large surface area, pore volume, amenability of their surface for functionalization, stable mesoporous structure, and biocompatibility.  Biomoecules loading capacitites,  release and target cell accumulation efficiencies have been improved for both antigen and nucleic acid delivery by the synthesis of large-pore MSN, dendritic MSN, hollow-core MSN, and multifunctional MSN. This article overview the major advances in the use of MSN for delivery of antigens and therapeutic nucleic acids such as DNA, siRNA, and miRNA aimed for treatment of various diseases.       

How Regenerative Medicine Can Benefit from Nucleic Acids Delivery Nanocarriers?

2015 ◽  
pp. 285-336
Author(s):  
Erea Borrajo ◽  
Anxo Vidal ◽  
Maria J. Alonso ◽  
Marcos Garcia-Fuentes
Keyword(s):  
Regenerative Medicine ◽  
Nucleic Acids ◽  
Nucleic Acids Delivery

scholarly journals i-GONAD (improved genome-editing via oviductal nucleic acids delivery), a convenient in vivo tool to produce genome-edited rats

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shuji Takabayashi ◽  
Takuya Aoshima ◽  
Katsuya Kabashima ◽  
Kazushi Aoto ◽  
Masato Ohtsuka ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Genome Editing ◽  
Nucleic Acids Delivery

Self-Assembled DNA Nanostructures-Based Nanocarriers Enabled Functional Nucleic Acids Delivery

2020 ◽  
Vol 3 (5) ◽  
pp. 2779-2795 ◽  
Author(s):  
Jin Huang ◽  
Wenjie Ma ◽  
Huanhuan Sun ◽  
Huizhen Wang ◽  
Xiaoxiao He ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Dna Nanostructures ◽  
Self Assembled ◽  
Nucleic Acids Delivery ◽  
Functional Nucleic Acids

Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

MedChemComm ◽  
2010 ◽  
Vol 1 (1) ◽  
pp. 76 ◽  
Author(s):  
Guilhem Godeau ◽  
Hélène Arnion ◽  
Christophe Brun ◽  
Cathy Staedel ◽  
Philippe Barthélémy
Keyword(s):  
Nucleic Acids ◽  
Nucleic Acids Delivery ◽  
Oligonucleotide Conjugates
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