Polymer Brush Controlled Bioinspired Calcium Phosphate Mineralization and Bone Cell Growth

2011 ◽  
Vol 12 (10) ◽  
pp. 3753-3760 ◽  
Author(s):  
Ruben Löbbicke ◽  
Munish Chanana ◽  
Helmut Schlaad ◽  
Christine Pilz-Allen ◽  
Christina Günter ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Cell Growth ◽  
Polymer Brush ◽  
Bone Cell ◽  
Phosphate Mineralization

scholarly journals Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1165 ◽  
Author(s):  
Tobias Mai ◽  
Karol Wolski ◽  
Agnieszka Puciul-Malinowska ◽  
Alexey Kopyshev ◽  
Ralph Gräf ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Polymer Brushes ◽  
Polymer Brush ◽  
Inorganic Component ◽  
Hybrid Films ◽  
Anionic Polymer ◽  
Phosphate Mineralization ◽  
Application Potential ◽  
Good Biocompatibility ◽  
Growth Experiments

This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.

scholarly journals Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

2017 ◽  
Vol 8 ◽  
pp. 772-783 ◽  
Author(s):  
Mohamed Hamed Misbah ◽  
Mercedes Santos ◽  
Luis Quintanilla ◽  
Christina Günter ◽  
Matilde Alonso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Click Chemistry ◽  
Recombinant Dna ◽  
Fibrillar Structure ◽  
Cross Link ◽  
Recombinant Dna Technology ◽  
Peptide Epitope ◽  
Phosphate Mineralization ◽  
Potential Applications ◽  
Dna Technology

Understanding the mechanisms responsible for generating different phases and morphologies of calcium phosphate by elastin-like recombinamers is supreme for bioengineering of advanced multifunctional materials. The generation of such multifunctional hybrid materials depends on the properties of their counterparts and the way in which they are assembled. The success of this assembly depends on the different approaches used, such as recombinant DNA technology and click chemistry. In the present work, an elastin-like recombinamer bearing lysine amino acids distributed along the recombinamer chain has been cross-linked via Huisgen [2 + 3] cycloaddition. The recombinamer contains the SNA15 peptide domains inspired by salivary statherin, a peptide epitope known to specifically bind to and nucleate calcium phosphate. The benefit of using click chemistry is that the hybrid elastin-like-statherin recombinamers cross-link without losing their fibrillar structure. Mineralization of the resulting hybrid elastin-like-statherin recombinamer hydrogels with calcium phosphate is described. Thus, two different hydroxyapatite morphologies (cauliflower- and plate-like) have been formed. Overall, this study shows that crosslinking elastin-like recombinamers leads to interesting matrix materials for the generation of calcium phosphate composites with potential applications as biomaterials.

scholarly journals Understanding the early stages of calcium phosphate mineralization through hyperpolarized NMR techniques.

2021 ◽  
Author(s):  
Tristan Georges ◽  
Ludovica Epasto ◽  
Albina Selimović ◽  
Dennis Kurzbach ◽  
Thierry Azaïs
Keyword(s):  
Calcium Phosphate ◽  
Early Stages ◽  
Phosphate Mineralization ◽  
Nmr Techniques

scholarly journals Poly(ethylene imine)-Controlled Calcium Phosphate Mineralization

Langmuir ◽  
2008 ◽  
Vol 24 (5) ◽  
pp. 2102-2109 ◽  
Author(s):  
Andriy Shkilnyy ◽  
Alwin Friedrich ◽  
Brigitte Tiersch ◽  
Stefanie Schöne ◽  
Mabya Fechner ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Ethylene Imine ◽  
Phosphate Mineralization ◽  
Poly Ethylene

Calcium phosphate mineralization with linear poly(ethylene imine): a time-resolved study

2011 ◽  
Vol 289 (8) ◽  
pp. 881-888 ◽  
Author(s):  
Andriy Shkilnyy ◽  
Stefanie Schöne ◽  
Claudia Rumplasch ◽  
Annett Uhlmann ◽  
Annett Hedderich ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Ethylene Imine ◽  
Time Resolved ◽  
Phosphate Mineralization ◽  
Linear Poly ◽  
Poly Ethylene

Accelerated Calcium Phosphate Mineralization by Peptides with Adjacent Oppositely Charged Residues

2020 ◽  
Vol 6 (7) ◽  
pp. 3791-3798 ◽  
Author(s):  
Mustafa Gungormus ◽  
Mahmut Sertac Ozdogan ◽  
Sinan Yasin Ertem ◽  
Fatih Tulumbaci ◽  
Halil Kara ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Charged Residues ◽  
Phosphate Mineralization ◽  
Oppositely Charged

Bioinspired multifunctional TiO2 hierarchical micro/nanostructures with tunable improved bone cell growth and inhibited bacteria adhesion

2020 ◽  
Vol 46 (7) ◽  
pp. 9669-9679
Author(s):  
S.Y. Rahnamaee ◽  
R. Bagheri ◽  
M. Vossoughi ◽  
Sh. Ahmadi Seyedkhani ◽  
A. Samadikuchaksaraei
Keyword(s):  
Cell Growth ◽  
Bone Cell ◽  
Bacteria Adhesion
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