Compatible Ternary Blends of Chitosan/poly(vinyl alcohol)/poly(lactic acid) Produced by Oil-in-Water Emulsion Processing

2011 ◽  
Vol 12 (4) ◽  
pp. 907-914 ◽  
Author(s):  
Rafael Grande ◽  
Antonio J. F. Carvalho
Keyword(s):  
Lactic Acid ◽  
Vinyl Alcohol ◽  
Poly Lactic Acid ◽  
Poly Vinyl Alcohol ◽  
Ternary Blends ◽  
Water Emulsion ◽  
Oil In Water ◽  
Emulsion Processing ◽  
Oil In Water Emulsion

Preparation of Porous Poly(Lactic Acid)/Hydroxyapatite Microspheres Intended for Injectable Bone Substitutes

2005 ◽  
Vol 284-286 ◽  
pp. 819-822 ◽  
Author(s):  
Fukue Nagata ◽  
Tatsuya Miyajima ◽  
Kay Teraoka ◽  
Yoshiyuki Yokogawa
Keyword(s):  
Lactic Acid ◽  
Bone Ingrowth ◽  
Bone Substitutes ◽  
Single Step ◽  
Poly Lactic Acid ◽  
Biodegradable Microspheres ◽  
Water Emulsion ◽  
Internal Water ◽  
Oil In Water ◽  
Oil In Water Emulsion

Porous biodegradable microspheres were successfully obtained by an improvement single step and surfactant-free emulsion solvent evaporation method. The organic phase composed of PLA and dichloromethane was stirred in aqueous phase including Ca2+ ions to yield oil in water emulsion. During emulsification, stirring rate was increased so as to produce the W/O/W emulsion that results in microspheres with internal pores. The interface of internal water/oil was stable in W/O/W emulsion, which was explained that the bond between Ca2+ ions and carboxyl group of poly(lactic acid) would be stabilized the internal water/oil interface. Adding PO4 3- aqueous solution prompted to precipitate low crystallized hydroxyapatite on the external oil/water interface, and the precipitated hydroxyapatite would stabilizied microspheres formation. The resulting microspheres were approximately 100-500 µm with internal spherical pores of 10-200 µm in diameter. The porous biodegradable microspheres were expected to be utilized as injectable bone substitutes that allow bone ingrowth and bone regeneration.

scholarly journals Preparations of Poly(lactic acid) Dispersions in Water for Coating Applications

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2767
Author(s):  
Giada Belletti ◽  
Sara Buoso ◽  
Lucia Ricci ◽  
Alejandro Guillem-Ortiz ◽  
Alejandro Aragón-Gutiérrez ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Gel Permeation Chromatography ◽  
Sem Analysis ◽  
Water Phase ◽  
Poly Lactic Acid ◽  
Water Emulsion ◽  
Preparation Conditions ◽  
Ft Ir ◽  
Homogenization Methods ◽  
Oil In Water Emulsion

A green, effective methodology for the preparation of water-based dispersions of poly(lactic acid) (PLA) for coating purposes is herein presented. The procedure consists of two steps: in the first one, an oil-in-water emulsion is obtained by mixing a solution of PLA in ethyl acetate with a water phase containing surfactant and stabilizer. Different homogenization methods as well as oil/water phase ratio, surfactant and stabilizer combinations were screened. In the second step, the quantitative evaporation of the organic provides water dispersions of PLA that are stable, at least, over several weeks at room temperature or at 4 °C. Particle size was in the 200–500 nm range, depending on the preparation conditions, as confirmed by scanning electron microscope (SEM) analysis. PLA was found not to suffer significant molecular weight degradation by gel permeation chromatography (GPC) analysis. Furthermore, two selected formulations with glass transition temperature (Tg) of 51 °C and 34 °C were tested for the preparation of PLA films by drying in PTFE capsules. In both cases, continuous films that are homogeneous by Fourier-transform infrared spectroscopy (FT-IR) and SEM observation were obtained only when drying was performed above 60 °C. The formulation with lower Tg results in films which are more flexible and transparent.

Fabrication of core-shell structured nanofibers of poly (lactic acid) and poly (vinyl alcohol) by coaxial electrospinning for tissue engineering

2018 ◽  
Vol 98 ◽  
pp. 483-491 ◽  
Author(s):  
Hamad F. Alharbi ◽  
Monis Luqman ◽  
Khalil Abdelrazek Khalil ◽  
Yasser A. Elnakady ◽  
Omar H. Abd-Elkader ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Vinyl Alcohol ◽  
Poly Lactic Acid ◽  
Poly Vinyl Alcohol ◽  
Coaxial Electrospinning ◽  
Core Shell

Nanocomposites based on biocompatible polymers and graphene oxide for antibacterial coatings

2021 ◽  
pp. 096739112110206
Author(s):  
Fika Fauzi ◽  
Muhammad Miqdam Musawwa ◽  
Habibi Hidayat ◽  
Ahmad Kusumaatmaja ◽  
Wipsar Sunu Brams Dwandaru
Keyword(s):  
Antibacterial Activity ◽  
Graphene Oxide ◽  
Lactic Acid ◽  
Essential Oils ◽  
Vinyl Alcohol ◽  
Poly Lactic Acid ◽  
Poly Vinyl Alcohol ◽  
Biocompatible Polymers ◽  
Antibacterial Coatings ◽  
The World

Recently, antibacterial coatings based on graphene oxide (GO) nanocomposites have attracted many studies around the world. The use of polymers as the matrices of GO nanofillers in the nanocomposites has been explored to produce efficient coatings against bacteria. One of the most prospective applications is the incorporation of GO into biocompatible polymers, which can produce antibacterial coatings. Here, recent progresses on the antibacterial coatings of nanocomposites based on biocompatible polymers and GO are reviewed. The effect of GO filler concentrations, biocide materials, and biocompatibility are discussed to find the most efficient antibacterial activity and biocompatibility of nanocomposites. Among biocompatible polymers, chitosan (Cs), poly vinyl alcohol (PVA), and poly lactic acid (PLA) are the most popular matrices used for the nanocomposites. This review also elaborates challenges in the use of other biocompatible polymers. Future works on biocompatible antibacterial coatings should be conducted by considering the concentration of GO nanofillers or adding other materials such as essential oils to suppress the toxicity toward functional cells.

A novel hemostat and antibacterial nanofibrous scaffold based on poly(vinyl alcohol)/poly(lactic acid)

2020 ◽  
Vol 35 (3) ◽  
pp. 189-202 ◽  
Author(s):  
Reyhaneh Fatahian ◽  
Mohammad Mirjalili ◽  
Ramin Khajavi ◽  
Mohammad Karim Rahimi ◽  
Navid Nasirizadeh
Keyword(s):  
Lactic Acid ◽  
Blood Coagulation ◽  
Vinyl Alcohol ◽  
Modern Society ◽  
Fibroblast Cell ◽  
Poly Lactic Acid ◽  
Poly Vinyl Alcohol ◽  
Gel Formation ◽  
Nanofibrous Scaffolds ◽  
Novel Scaffold

Today, an advanced wound dressing with the ability of blood clotting and antibacterial activity is the main subject of many studies to consider their necessity in modern society. In this study, it was aimed to present a novel scaffold with both abilities simultaneously. Poly(vinyl alcohol)/poly(lactic acid) nanofibrous scaffolds containing ceftriaxone antimicrobial agent (PVA-CTX/PLA) and tranexamic acid coagulant (PVA-CTX-TXA/PLA) were fabricated by electrospinning method. Morphology, antimicrobial activity, blood coagulation and bioavailability indexes, and swelling ability (gel formation) of produced samples were determined. Morphological results showed that the hybrid nanofibers were form successfully. The antibacterial efficiency of them against Gram-negative ( Escherichia coli) and Gram-positive ( Staphylococcus aureus) bacteria was more than 90% for PVA-CTX/PLA and it reached 100% for PVA-CTX-TXA/PLA. Both PVA-CTX-TXA/PLA and PVA-TXA/PLA scaffolds showed acceptable blood coagulation ability with an average absorption of 0.043 and 0.036 nm, respectively. PVA-CTX-TXA/PLA scaffolds had a gel formation ability of about 45 min. All scaffolds were successful in cell proliferation (L929 fibroblast cell) after 48 h.

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