Composite Nanoparticles Based on Hyaluronic Acid Chemically Cross-Linked with α,β-Polyaspartylhydrazide

2007 ◽  
Vol 8 (6) ◽  
pp. 1890-1898 ◽  
Author(s):  
G. Pitarresi ◽  
E. F. Craparo ◽  
F. S. Palumbo ◽  
B. Carlisi ◽  
G. Giammona
Keyword(s):  
Hyaluronic Acid ◽  
Composite Nanoparticles

Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors

2015 ◽  
Vol 3 (47) ◽  
pp. 9098-9108 ◽  
Author(s):  
Yong Hu ◽  
Jia Yang ◽  
Ping Wei ◽  
Jingchao Li ◽  
Ling Ding ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ct Imaging ◽  
Composite Nanoparticles ◽  
Dual Mode ◽  
Facile Synthesis

Hyaluronic acid-modified Fe3O4/Au composite nanoparticles can be synthesized for targeted dual mode MR/CT imaging of tumors.

Multifunctional composite nanoparticles based on hyaluronic acid-paclitaxel conjugates for enhanced cancer therapy

2020 ◽  
Vol 589 ◽  
pp. 119870 ◽  
Author(s):  
Kaipei Luo ◽  
Shaoping Yin ◽  
Ruixia Zhang ◽  
Hua Yu ◽  
Guangji Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Composite Nanoparticles

Health Informatics of Composite Nanoparticles as an Effective Contrast Agent in Magnetic Resonance Imaging and for Glioblastoma Radiosensitization

2020 ◽  
Vol 10 (12) ◽  
pp. 2825-2833
Author(s):  
Yuehan Dong ◽  
Liyu Xu ◽  
Gang Qin ◽  
Xiao Zhao ◽  
Xinlei Chen
Keyword(s):  
Cell Proliferation ◽  
Hyaluronic Acid ◽  
Contrast Agent ◽  
Mass Concentration ◽  
Proliferation Rate ◽  
Composite Nanoparticles ◽  
Logarithmic Growth Phase ◽  
X Ray ◽  
Cell Proliferation Rate ◽  
Logarithmic Growth

Background: Radiation therapy is a method using radiation to treat tumors, and has become commonly used and most effective treatments for malignant tumors. However, radiotherapy still has the shortcomings of high radiation dose, especially radiation resistance of tumor cells. Multifunctional nanoradiosensitizers can enhance the radiosensitivity of tumor cells and improving the effect of radiotherapy. Hyaluronic acid-functionalized ironbismuth composite particles are an effective contrast agent for magnetic resonance imaging (MRI), and can be used as radiosensitizers. Method: Hyaluronic acid-functionalized iron-bismuth composite nanoparticles HABilOPs can be prepared by a hydrothermal polyol method. In the cytotoxicity experiment, we took human glioblastoma cell line U87MG in logarithmic growth phase and rat vascular smooth muscle cells. We set different mass concentrations of 0, 15, 30, 45, 60, 100, and 300 mg/LHA-BMOPs was cultured for 48 h to calculate the cell proliferation rate. In the histocompatibility experiment, we injected HA-BilOPs solution into the tail vein of ICR mice to observe the pathological changes of mouse organs. In the radiosensitization experiment, we took U87MG cells in logarithmic growth phase for group culture. X-ray irradiation of 0, 3, 6, 9 Gy was given, and the HA-BilOPs group was added with culture medium of different mass concentration of LHA-BilOPs, and the combined group was added to the culture medium of different mass concentration of HA-BilOPs first, and then given X-ray irradiation of 0, 3, 6, 9 Gy. To analyse the features of glioblastoma, the conventional MRI manifestations of glioblastoma were examined. Results: We found that different concentrations of HA-BilOPs had no significant effect on the proliferation of vascular smooth muscle cells and U87MG cells. It was found that no pathological changes occurred in mouse organs after tail vein injection of HA-BilOPs solution. Nanoparticles can be phagocytosed by U87MG cells and it was found that U87MG cell proliferation rate had a significant linear negative correlation with HA-BilOPs mass concentration (0–200 mg/L) and radiation dose (0–9 Gy). At 6 Gy X Under irradiation, 200 mg/L HA-BilOPs reduced the cell proliferation rate to (41± 7)%. Using 100 mg/L HA-BilOPs and 6 Gy X-ray irradiation for colony formation experiments, the proliferation rate of U87MG cells in the combined group was statistically lower than that of the blank control group and radiotherapy group (P < 0.05). Conclusion: Hyaluronic acid-functionalized iron-bismuth composite nanoparticles have a significant radiosensitizing effect on glioblastoma and proved to be a good contrast agent used in MRI.

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