Structure−Property Relationships in Poly(ethylene glycol)−Protein Hydrogel Systems Made from Various Proteins

2005 ◽  
Vol 6 (3) ◽  
pp. 1635-1641 ◽  
Author(s):  
Kirill I. Shingel ◽  
Marie-Pierre Faure
Keyword(s):  
Ethylene Glycol ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Structure Property Relationships ◽  
Poly Ethylene

Structure–property relationships in novel poly(imide-amide)–poly(ethylene glycol) hybrid networks

Polymer ◽  
2006 ◽  
Vol 47 (1) ◽  
pp. 357-366 ◽  
Author(s):  
S. Kripotou ◽  
P. Pissis ◽  
P. Sysel ◽  
V. Sindelar ◽  
V.A. Bershtein
Keyword(s):  
Ethylene Glycol ◽  
Hybrid Networks ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Structure Property Relationships ◽  
Poly Ethylene ◽  
Poly Imide

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2553
Author(s):  
Jeffrey M. Ting ◽  
Alexander E. Marras ◽  
Joseph D. Mitchell ◽  
Trinity R. Campagna ◽  
Matthew V. Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Raft Polymerization ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Complex Micelles

A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-block-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure–property relationships centered on poly(ethylene glycol)-block-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-block-poly(l-lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a diameter ~1.5–2× larger when PMPC-PVBTMA was used compared to PEG-PLK and PEG-PVBTMA via SAXS and DLS. In addition, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

2020 ◽  
Author(s):  
Jeffrey Ting ◽  
Alexander Marras ◽  
Joseph Mitchell ◽  
Trinity Campagna ◽  
Matthew Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Core Diameter ◽  
Poly Ethylene ◽  
Complex Micelles

<p>A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure-property relationships centered on poly(ethylene glycol)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-<i>block</i>-poly(lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a core diameter of ~40 nm when PMPC-PVBTMA was used, and smaller particles between 20-30 nm for PEG-PLK and PEG-PVBTMA via SAXS analysis. Additionally, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.</p>

scholarly journals Novel Water Loving Coatings (WLC) Lubricious and Durable Guidewires

2017 ◽  
Author(s):  
Peter A. Edwards ◽  
Michael Price ◽  
Nick Nimchuk ◽  
Jeff Mahon
Keyword(s):  
Phenyl Isocyanate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Water Dispersible ◽  
Structure Property Relationships ◽  
Soft Segments ◽  
Hard Segments ◽  
Poly Ethylene ◽  
Hydrophilic Coatings ◽  
Glycol Methyl Ether

Hydrophilic coatings applied to guidewires or catheters, lower friction of the device thus improves handling and reduces damage to the vessel walls during access, delivery and retrieval. Peripheral guidewires typically consist of a polymer jacket, basecoat and topcoat. The polymer jacket is highly radiopaque for fluoroscopy visualization. Basecoat adheres to the polymer jacket and hydrophilic topcoat. Basecoat and topcoat play important roles towards coating device durability and lubricity. Water Loving Coatings (WLC) are the first developed 510(k) clearance guidewires utilizing epoxy polyurethane technology. Coatings are non-hemolytic and non-cytotoxic. WLC are advances toward glycidyl carbamate (GC) resins. Linear Glycidyl Carbamates have shown excellent flexibility based off structure property relationships [1]. Water dispersible GC (WD-GC) oligomers have been prepared by additions of poly(ethylene glycol) methyl ether (m-peg) to isocyanurate and biuret, then end capped with glycidol [2]. WLC technologies are lubricious and durable water dispersible polyurethane or polyurea glycidyl carbamates [3]. Modified Hyaluronate with WD-GC oligomers have shown increases in lubricity of Guidewires when used with a catheter [4]. WLC coatings have been applied to a micro-wire to reduce endothelial mechanical lining damage [5]. Common thermoplastic urethanes (TPU), similar to WLC morphology, used in the medical industry, are: Biomer and Lubrizol’s Pellethane®, Tecoflex™ and Estane™. Biomer consists of 4,4′-Methylenebis(phenyl isocyanate) (MDI), Ethylenediamine (EDA), and Polytetramethylene diol (Poly THF). Pellethane consists of MDI, 1,4-Butanediol (BDO) and Poly THF. Tecoflex consists of 4-4′-methylenebis (cyclohexyl isocyanate) (H12MDI), BDO and Poly THF. Medical grade Estane is an ester of adipic acid with BDO for soft segments and MDI and BDO for hard segments. TPU structure and morphology dictates polymeric properties.

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

2020 ◽  
Author(s):  
Jeffrey Ting ◽  
Alexander Marras ◽  
Joseph Mitchell ◽  
Trinity Campagna ◽  
Matthew Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Core Diameter ◽  
Poly Ethylene ◽  
Complex Micelles

<p>A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure-property relationships centered on poly(ethylene glycol)-<i>block</i>-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-<i>block</i>-poly(lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a core diameter of ~40 nm when PMPC-PVBTMA was used, and smaller particles between 20-30 nm for PEG-PLK and PEG-PVBTMA via SAXS analysis. Additionally, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.</p>

Structure–property relations of amphiphilic poly(furfuryl glycidyl ether)-block-poly(ethylene glycol) macromonomers at the air–water interface

2020 ◽  
Vol 11 (35) ◽  
pp. 5659-5668
Author(s):  
Karishma K. Adatia ◽  
Alexander Holm ◽  
Alexander Southan ◽  
Curtis W. Frank ◽  
Günter E. M. Tovar
Keyword(s):  
Ethylene Glycol ◽  
Glycidyl Ether ◽  
Water Interface ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Property Relations ◽  
Langmuir Film Balance ◽  
Air Water Interface ◽  
Film Balance ◽  
Poly Ethylene

Structure–property relations of poly(furfuryl glycidyl ether)-block-poly(ethylene glycol) macromonomers at the air–water interface are studied with a Langmuir film balance.

PIEZOELECTRIC PROPERTIES OF POLY(3-HYDROXYBUTYRATE-CO-3-HEDROXYBUTYRATE)-CO-POLY(ETHYLENE GLYCOL) PRODUCED BY CONTROLLED MICROBIOLOGICAL BIOSYNTHESIS

2019 ◽  
Vol 10 (10) ◽  
Author(s):  
Anton Bonartsev ◽  
Vera Voinova ◽  
Elizaveta Akoulina ◽  
Andrey Dudun ◽  
Irina Zharkova ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Piezoelectric Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Thermosensitives hydrogels based on poly (ethylene glycol): I. Synthesis, characterization and release

2007 ◽  
Vol 32 (5) ◽  
pp. 431-446 ◽  
Author(s):  
Tahar Bartil ◽  
Mahmoud Bounekhel ◽  
Cedric Calberg ◽  
Robert Jerome
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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