Development of a Process for the Biotechnological Large-Scale Production of 4-Hydroxyvalerate-Containing Polyesters and Characterization of Their Physical and Mechanical Properties

2001 ◽  
Vol 2 (1) ◽  
pp. 45-57 ◽  
Author(s):  
V. Gorenflo ◽  
G. Schmack ◽  
R. Vogel ◽  
A. Steinbüchel
Keyword(s):  
Mechanical Properties ◽  
Large Scale ◽  
Physical And Mechanical Properties ◽  
Scale Production ◽  
Large Scale Production

scholarly journals Large-scale production and physicochemical characterization of human immune interferon.

1979 ◽  
Vol 26 (1) ◽  
pp. 36-41 ◽  
Author(s):  
M P Langford ◽  
J A Georgiades ◽  
G J Stanton ◽  
F Dianzani ◽  
H M Johnson
Keyword(s):  
Large Scale ◽  
Physicochemical Characterization ◽  
Scale Production ◽  
Immune Interferon ◽  
Large Scale Production ◽  
Human Immune

scholarly journals Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

2011 ◽  
Vol 55 (5) ◽  
pp. 1975-1981 ◽  
Author(s):  
Matthew A. Gregory ◽  
Michael Bobardt ◽  
Susan Obeid ◽  
Udayan Chatterji ◽  
Nigel J. Coates ◽  
...  
Keyword(s):  
Large Scale ◽  
Scale Production ◽  
Subgenomic Replicon ◽  
Isomerase Activity ◽  
Lead Compounds ◽  
Naturally Occurring ◽  
Large Scale Production ◽  
Pharmacokinetic Properties ◽  
Biosynthetic Engineering

ABSTRACTCyclophilin inhibitors currently in clinical trials for hepatitis C virus (HCV) are all analogues of cyclosporine (CsA). Sanglifehrins are a group of naturally occurring cyclophilin binding polyketides that are structurally distinct from the cyclosporines and are produced by a microorganism amenable to biosynthetic engineering for lead optimization and large-scale production by fermentation. Preclinical characterization of the potential utility of this class of compounds for the treatment of HCV revealed that the natural sanglifehrins A to D are all more potent than CsA at disrupting formation of the NS5A-CypA, -CypB, and -CypD complexes and at inhibition of CypA, CypB, and CypD isomerase activity. In particular, sanglifehrin B (SfB) was 30- to 50-fold more potent at inhibiting the isomerase activity of all Cyps tested than CsA and was also shown to be a more potent inhibitor of the 1b subgenomic replicon (50% effective concentrations [EC50s] of 0.070 μM and 0.16 μM in Huh 5-2 and Huh 9-13 cells, respectively). Physicochemical and mouse pharmacokinetic analyses revealed low oral bioavailability (F< 4%) and low solubility (<25 μM), although the half-lives (t1/2) of SfA and SfB in mouse blood after intravenous (i.v.) dosing were long (t1/2> 5 h). These data demonstrate that naturally occurring sanglifehrins are suitable lead compounds for the development of novel analogues that are less immunosuppressive and that have improved metabolism and pharmacokinetic properties.

scholarly journals Characterization of graphene nanosheets obtained by a modified Hummer's method

2018 ◽  
Vol 23 (1) ◽  
Author(s):  
Renata Hack ◽  
Cláudia Hack Gumz Correia ◽  
Ricardo Antônio de Simone Zanon ◽  
Sérgio Henrique Pezzin
Keyword(s):  
Electron Microscopy ◽  
Large Scale ◽  
Graphene Nanosheets ◽  
Scale Production ◽  
Natural Graphite ◽  
Graphite Oxidation ◽  
Transmission Electron ◽  
Large Scale Production ◽  
High Degree

ABSTRACT Natural graphite is an inexpensive and abundant source to obtain graphene nanosheets. The most efficient method for large-scale production is the chemical method, which is based on the oxidation of natural graphite. This paper reports the synthesis and characterization of graphene obtained by the Hummers method with some modifications. The results indicate a high degree of graphite oxidation, proving that the process was efficient. Analyses of field emission scanning electron microscopy (FEG), transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetric analysis (TGA) and X-ray diffraction showed that the graphene produced presented characteristics similar to the commercial graphene.

Growth and characterization of high-efficiency InGaN MQW blue and green LEDs from large-scale-production MOCVD reactors

1999 ◽  
Author(s):  
Chuong A. Tran ◽  
Robert F. Karlicek, Jr. ◽  
Michael G. Brown ◽  
Ivan Eliashevich ◽  
Alexander Gurary ◽  
...  
Keyword(s):  
Large Scale ◽  
High Efficiency ◽  
Scale Production ◽  
Large Scale Production ◽  
Green Leds

scholarly journals Cloning, expression and characterization of l-asparaginase from Withania somnifera L. for large scale production

3 Biotech ◽  
2011 ◽  
Vol 1 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Vishal P. Oza ◽  
Pritesh P. Parmar ◽  
Darshan H. Patel ◽  
R. B. Subramanian
Keyword(s):  
Large Scale ◽  
Withania Somnifera ◽  
Scale Production ◽  
Large Scale Production

Large-Scale Production and Characterization of Biocompatible Colloidal Nanoalumina

Langmuir ◽  
2014 ◽  
Vol 30 (50) ◽  
pp. 15091-15101 ◽  
Author(s):  
W. A. W. Razali ◽  
V. K. A. Sreenivasan ◽  
E. M. Goldys ◽  
A. V. Zvyagin
Keyword(s):  
Large Scale ◽  
Scale Production ◽  
Large Scale Production
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