Multifunctional Nanoparticles in Radiation Oncology: An Emerging Paradigm

2014 ◽  
pp. 75-106 ◽  
Author(s):  
Jodi E. Belz ◽  
Wilfred Ngwa ◽  
Houari Korideck ◽  
Robert A. Cormack ◽  
Ross Berbeco ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Multifunctional Nanoparticles

Nuklearmedizin trifft Strahlentherapie

2010 ◽  
Vol 49 (S 01) ◽  
pp. S11-S15
Author(s):  
C. Schütze ◽  
M. Krause ◽  
A. Yaromina ◽  
D. Zips ◽  
M. Baumann
Keyword(s):  
Nuclear Medicine ◽  
Radiation Oncology ◽  
External Beam Radiotherapy ◽  
Biological Knowledge ◽  
Important Research ◽  
Tumour Control ◽  
Research Areas ◽  
Normal Tissue Damage ◽  
Local Tumour Control ◽  
Local Tumour

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

Radiation oncology and functional imaging

2005 ◽  
Vol 44 (S 01) ◽  
pp. S38-S40
Author(s):  
Th. Herrmann
Keyword(s):  
Functional Imaging ◽  
Radiation Oncology ◽  
Bronchogenic Carcinoma ◽  
Brain Tumours ◽  
Tumour Volume ◽  
Target Volume ◽  
Head And Neck Tumours ◽  
Pet Ct ◽  
Surrounding Healthy Tissue ◽  
Prostate Carcinomas

Summary:PET/CT imaging is most likely to be of use in radiation oncology with patients who have poorly defined target volume areas, e.g. brain tumours, bronchogenic carcinoma, and cases of miscellaneous geographical miss. Other tumours that call for dose escalated radiotherapy, such as head and neck tumours, bronchogenic carcinoma, and prostate carcinomas may further benefit from an accurate delineation of the metabolically active tumour volume and its differentiation from surrounding healthy tissue, or tumour atelectasis.

The Role of the Initiator System in the Synthesis of Acidic Multifunctional Nanoparticles Designed for Molecular Imprinting of Proteins

2020 ◽  
Vol 65 (1) ◽  
pp. 28-41
Author(s):  
Marwa Aly Ahmed ◽  
Júlia Erdőssy ◽  
Viola Horváth
Keyword(s):  
Acrylic Acid ◽  
Binding Affinity ◽  
Molecular Imprinting ◽  
Low Temperatures ◽  
Ammonium Persulfate ◽  
Sodium Bisulfite ◽  
Multifunctional Nanoparticles ◽  
High Affinity ◽  
Initiator System

Multifunctional nanoparticles have been shown earlier to bind certain proteins with high affinity and the binding affinity could be enhanced by molecular imprinting of the target protein. In this work different initiator systems were used and compared during the synthesis of poly (N-isopropylacrylamide-co-acrylic acid-co-N-tert-butylacrylamide) nanoparticles with respect to their future applicability in molecular imprinting of lysozyme. The decomposition of ammonium persulfate initiator was initiated either thermally at 60 °C or by using redox activators, namely tetramethylethylenediamine or sodium bisulfite at low temperatures. Morphology differences in the resulting nanoparticles have been revealed using scanning electron microscopy and dynamic light scattering. During polymerization the conversion of each monomer was followed in time. Striking differences were demonstrated in the incorporation rate of acrylic acid between the tetramethylethylenediamine catalyzed initiation and the other systems. This led to a completely different nanoparticle microstructure the consequence of which was the distinctly lower lysozyme binding affinity. On the contrary, the use of sodium bisulfite activation resulted in similar nanoparticle structural homogeneity and protein binding affinity as the thermal initiation.

The Solo Practice of Medical Physics in Radiation Oncology

10.37206/80 ◽  
2003 ◽  
Author(s):  
Per H. Halvorsen ◽  
Julie F. Dawson ◽  
Martin W. Fraser ◽  
Geoffrey S. Ibbott ◽  
Bruce R. Thomadsen
Keyword(s):  
Radiation Oncology ◽  
Medical Physics ◽  
Solo Practice

Comprehensive QA for Radiation Oncology

10.37206/45 ◽  
1994 ◽  
Author(s):  
Gerald J. Kutcher ◽  
Lawrence Coia ◽  
Michael Gillin ◽  
William F. Hanson ◽  
Steven Leibel ◽  
...  
Keyword(s):  
Radiation Oncology

Standardizing Nomenclatures in Radiation Oncology

10.37206/171 ◽  
2018 ◽  
Author(s):  
Charles Mayo id Fuller Ellen D. Yorke Jatinder R. Palta Peter ◽  
Jean Moran ◽  
Walter Bosch ◽  
Ying Xiao ◽  
Todd McNutt ◽  
...  
Keyword(s):  
Radiation Oncology
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