Gold Nanoparticles for the Development of Transdermal Delivery Systems

2012 ◽  
pp. 69-80 ◽  
Author(s):  
Dakrong Pissuwan ◽  
Takuro Niidome
Keyword(s):  
Gold Nanoparticles ◽  
Transdermal Delivery ◽  
Delivery Systems

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

Development of antimigraine transdermal delivery systems of pizotifen malate

2015 ◽  
Vol 492 (1-2) ◽  
pp. 223-232 ◽  
Author(s):  
C.E. Serna-Jiménez ◽  
S. del Rio-Sancho ◽  
M.A. Calatayud-Pascual ◽  
C. Balaguer-Fernández ◽  
A. Femenía-Font ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems

scholarly journals Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010 ◽  
Vol 13 (2) ◽  
pp. 286 ◽  
Author(s):  
Tailane Sant´Anna Moreira ◽  
Valéria Pereira De Sousa ◽  
Maria Bernadete Riemma Pierre
Keyword(s):  
Oleic Acid ◽  
Rheological Behavior ◽  
Transdermal Delivery ◽  
In Vitro Release ◽  
Delivery Systems ◽  
Penetration Enhancer ◽  
Release Studies ◽  
Vitro Release ◽  
Gel Transition

Abstract PURPOSE: Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetration enhancer, on the in vitro release of LM from poloxamer-based delivery systems (PBDS). The rheological behavior (shear rate dependent viscosity) and gelation temperature through measurements of optimal sol-gel transition temperatures (Tsol-gel) were also carried out in these systems. METHODS: In vitro release studies of LM from PBDS were performed using cellulose acetate as artificial membrane mounted in a diffusion system. The amount of LM released was divided by exposition area (µg/cm2) and these values were plotted as function of the time (h). The flux of the drug across the membrane (J) was calculated from the slope of the linear portion of the plot and expressed as µg/cm2. h -1. The determination of viscosity was carried out at different shear rates (γ) between 0.1- 1000 S-1 using a parallel plate rheometer. Oscillatory measurements using a cone-plate geometry rheometer surrounded by a double jacket with temperature varying 4-40°C, was used in order to determine Tsol-gel. RESULTS: Increase of both polymer and OA concentrations increases the viscosity of the gels and consequently reduces the in vitro LM release from the PBDS, mainly for gels containing OA at 10.0% compared to other concentrations of the penetration enhancer. Tsol-gel transition temperature was decreased by increasing viscosity; in some cases the formulation was already a gel at room temperature. Rheological studies showed a pseudoplastic behavior, which facilitates the flow and improves the spreading characteristics of the formulations. CONCLUSIONS: Taken together, the results showed that poloxamer gels are good potential delivery systems for LM, leading to a sustained release, and also have appropriate rheological characteristics. Novelty of the work: A transdermal delivery of non-steroidal antinflammatory drugs like lumiracoxib (LM) can be an interesting alternative to the oral route of this drug, since it was recently withdraw of the market due to the liver damage when systemically administered in tablets as dosage form. There are no transdermal formulations of LM and it could be an alternative to treat inflammation caused by arthritis or arthrosis. Then, an adequate delivery system to LM is necessary in order to release the drug properly from the PBDS as well as have good characteristics related to semi-solid preparations for transdermal application, which were evaluated through in vitro release studies and rheological behavior in this paper, respectively.

scholarly journals Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 855 ◽  
Author(s):  
Shakthi Apsara Thejani Opatha ◽  
Varin Titapiwatanakun ◽  
Romchat Chutoprapat
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems ◽  
Transdermal Administration ◽  
Factors Affecting ◽  
Molecular Weights ◽  
Parenteral Delivery ◽  
Amphiphilic Drug ◽  
Bilayered Structure ◽  
Pass Through ◽  
Improve Patient

Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the therapeutic agents. The greatest challenge of transdermal delivery systems is the barrier function of the skin’s outermost layer. Molecules with molecular weights greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, only a limited number of drugs are capable of being administered by this route. Encapsulating the drugs in transfersomes are one of the potential approaches to overcome this problem. They have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic, as well as amphiphilic, drug with higher permeation efficiencies compared to conventional liposomes. Transfersomes are elastic in nature, which can deform and squeeze themselves as an intact vesicle through narrow pores that are significantly smaller than its size. This review aims to describe the concept of transfersomes, the mechanism of action, different methods of preparation and characterization and factors affecting the properties of transfersomes, along with their recent applications in the transdermal administration of drugs.

Transdermal delivery of poly(ethylene glycol)-co-oleylamine modified gold nanoparticles: Effect of size and shape

2019 ◽  
Vol 224 ◽  
pp. 22-28 ◽  
Author(s):  
Pa Fan Hsiao ◽  
Hsieh-Chih Tsai ◽  
Sydney Peng ◽  
Adhimoorthy Prasannan ◽  
Ting-Cheng Tang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Transdermal Delivery ◽  
Poly Ethylene Glycol ◽  
Size And Shape ◽  
Poly Ethylene

Raman mapping of fentanyl transdermal delivery systems with off-label modifications

The Analyst ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. 953-962 ◽  
Author(s):  
Teng Xu ◽  
Huzeyfe Yilmaz ◽  
Daniel R. Willett ◽  
Caroline Strasinger ◽  
Jason D. Rodriguez ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Delivery Systems ◽  
Crystal Formation ◽  
Raman Mapping ◽  
Off Label

Raman mapping and chemometric models were used to characterize crystal formation in fentanyl transdermal delivery systems resulting from off-label modifications.

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