State of the Art Mass Spectrometric and Chromatographic Techniques for Drug Analysis

2008 ◽  
pp. 283-298
Author(s):  
Katerina Mastovska
Keyword(s):  
State Of The Art ◽  
Drug Analysis ◽  
Mass Spectrometric ◽  
Chromatographic Techniques

scholarly journals Retrospective survey on drugs seized in Niger from 2013 to 2016 and state of the art on drug analysis and detection techniques

2020 ◽  
Vol 5 ◽  
pp. 238-248
Author(s):  
Fadjimata Salifou Karimoune ◽  
Adamou Rabani ◽  
Zangui Hamissou
Keyword(s):  
Juvenile Delinquency ◽  
Drug Users ◽  
Crack Cocaine ◽  
State Of The Art ◽  
Central Africa ◽  
Central Office ◽  
Drug Analysis ◽  
Age Group ◽  
Detection Techniques ◽  
The People

Drug is a substance, which trouble brain. One of the reasons for juvenile delinquency is drug use. The present work is a retrospective study based on seizures of drugs made by the Niger courts and. Evaluation of the drug utilization by people according to the statistics of drug seizures from 2013 to 2016 of the Central Office for the Suppression of Illegal Traffic in Narcotics (OCRTIS).  According to the statistics of drug seizures from 2013 to 2016 of the Central Office for the Suppression of Illegal Traffic in Narcotics (OCRTIS). Nine (9) types of drugs belonging to six (6) families were seized in Niger including: Amphetamines, Cannabis, Crack, Cocaine, Diazepam, Ephedrine, Heroin, Methamphetamines and Tramadol. These come from all countries bordering Niger but also from East Africa and Central Africa and the data gathered was analyzed using MS Excel. It should be noted that the percentage of those charged varies according to age group whose: the under 18’s are 6%, 59% are between 18 and 29 years, 25% are between 30 and 39 years, the 40 years and over are 10%. So most of the people which have been arrested are minors between 18 and 39 years old. In addition, it is necessary to mention 2% of women against 98 % of men in the said sale and consumption. If the number of seizures increases each year, the possibility of drug consumption by its users would also grow and highlights important diseases related to their consumption. Thus, the more appropriate implication of the blood and urine tests of these drug users.

scholarly journals MEMO: Mass Spectrometry-based Sample Vectorization to Explore Chemodiverse Datasets

2021 ◽  
Author(s):  
Arnaud Gaudry ◽  
Florian Huber ◽  
Louis-Felix Nothias ◽  
Sylvian Cretton ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Large Scale ◽  
State Of The Art ◽  
Mass Spectrometric ◽  
Bioactive Molecules ◽  
Computational Time ◽  
Mass Spectral ◽  
Experimental Variation ◽  
Alignment Step ◽  
Feature Alignment

In natural products research, chemodiverse extracts coming from multiple organisms are explored for novel bioactive molecules, sometimes over extended periods. Samples are usually analyzed by liquid chromatography coupled with fragmentation mass spectrometry to acquire informative mass spectral ensembles. Such data is then exploited to establish relationships among analytes or samples (e.g. via molecular networking) and annotate metabolites. However, the comparison of samples profiled in different batches is challenging with current metabolomics methods. Indeed, the experimental variation - changes in chromatographical or mass spectrometric conditions - often hinders the direct comparison of the profiled samples. Here we introduce MEMO - MS2 BasEd SaMple VectOrization - a method allowing to cluster large amounts of chemodiverse samples based on their LC-MS/MS profiles in a retention time agnostic manner. This method is particularly suited for heterogeneous and chemodiverse sample sets. MEMO demonstrated similar clustering performance as state-of-the-art metrics taking into account fragmentation spectra. More importantly, such performance was achieved without the requirement of a prior feature alignment step and in a significantly shorter computational time. MEMO thus allows the comparison of vast ensembles of samples, even when analyzed over long periods of time, and on different chromatographic or mass spectrometry platforms. This new addition to the computational metabolomics toolbox should drastically expand the scope of large-scale comparative analysis.

Newer mass spectrometric and chromatographic techniques in taxonomic studies of erythrina alkaloids

1975 ◽  
Vol 14 (3) ◽  
pp. 861
Author(s):  
D.E. Games ◽  
A.H. Jackson ◽  
N.A. Khan ◽  
S.A. Matlin ◽  
D.S. Millington ◽  
...  
Keyword(s):  
Mass Spectrometric ◽  
Chromatographic Techniques ◽  
Erythrina Alkaloids ◽  
Taxonomic Studies

scholarly journals Good quantification practices of flavours and fragrances by mass spectrometry

2016 ◽  
Vol 374 (2079) ◽  
pp. 20150365 ◽  
Author(s):  
Frédéric Begnaud ◽  
Alain Chaintreau
Keyword(s):  
Mass Spectrometry ◽  
Method Validation ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Complex Media ◽  
Quantitative Mass Spectrometry ◽  
Chromatographic Techniques ◽  
The Past ◽  
Real Matrices

Over the past 15 years, chromatographic techniques with mass spectrometric detection have been increasingly used to monitor the rapidly expanded list of regulated flavour and fragrance ingredients. This trend entails a need for good quantification practices suitable for complex media, especially for multi-analytes. In this article, we present experimental precautions needed to perform the analyses and ways to process the data according to the most recent approaches. This notably includes the identification of analytes during their quantification and method validation, when applied to real matrices, based on accuracy profiles. A brief survey of application studies based on such practices is given. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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