Antibody Modified Collagen Matrix for Site-Specific Gene Delivery

2008 ◽  
pp. 243-261
Author(s):  
Xu Jin ◽  
Lanxia Liu ◽  
Lin Mei ◽  
Xigang Leng ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Collagen Matrix ◽  
Specific Gene ◽  
Site Specific

scholarly journals Development of stealth liposomes functionalized with cyclic RGDfK peptide in microfluidics for site-specific gene delivery

2017 ◽  
Author(s):  
Gabriel Perli ◽  
Lucimara Gaziola de La Torre ◽  
Amanda da Costa e Silva de Noronha Pessoa
Keyword(s):  
Gene Delivery ◽  
Specific Gene ◽  
Site Specific ◽  
Stealth Liposomes

Inflamed Site-Specific Gene Delivery Using Bone Marrow-Derived CD11b+CD18+Vehicle Cells in Mice

1998 ◽  
Vol 9 (12) ◽  
pp. 1731-1738 ◽  
Author(s):  
Takashi Yokoo ◽  
Yasunori Utsunomiya ◽  
Toya Ohashi ◽  
Toshiyuki Imasawa ◽  
Taroh Kogure ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Gene Delivery ◽  
Specific Gene ◽  
Site Specific

scholarly journals Multi-Responsive “Turn-On” Nanocarriers for Efficient Site-Specific Gene Delivery In Vitro and In Vivo

2016 ◽  
Vol 5 (21) ◽  
pp. 2799-2812 ◽  
Author(s):  
Yiyan He ◽  
Jie Zhou ◽  
Shengnan Ma ◽  
Yu Nie ◽  
Dong Yue ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Specific Gene ◽  
Site Specific ◽  
Turn On

scholarly journals Development of Site Specific Gene Delivery System with Sonoporation

2008 ◽  
Vol 128 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Ryo SUZUKI ◽  
Yusuke ODA ◽  
Eisuke NAMAI ◽  
Tomoko TAKIZAWA ◽  
Yoichi NEGISHI ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Specific Gene ◽  
Gene Delivery System ◽  
Site Specific

scholarly journals Transient, Inducible, Placenta-Specific Gene Expression in Mice

Endocrinology ◽  
2012 ◽  
Vol 153 (11) ◽  
pp. 5637-5644 ◽  
Author(s):  
Xiujun Fan ◽  
Matthew Petitt ◽  
Matthew Gamboa ◽  
Mei Huang ◽  
Sabita Dhal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Delivery ◽  
Transgene Expression ◽  
Firefly Luciferase ◽  
Specific Gene ◽  
Dependent Manner ◽  
Control Of Gene Expression ◽  
Site Specific ◽  
Specific Gene Expression ◽  
High Level

Abstract Molecular understanding of placental functions and pregnancy disorders is limited by the absence of methods for placenta-specific gene manipulation. Although persistent placenta-specific gene expression has been achieved by lentivirus-based gene delivery methods, developmentally and physiologically important placental genes have highly stage-specific functions, requiring controllable, transient expression systems for functional analysis. Here, we describe an inducible, placenta-specific gene expression system that enables high-level, transient transgene expression and monitoring of gene expression by live bioluminescence imaging in mouse placenta at different stages of pregnancy. We used the third generation tetracycline-responsive tranactivator protein Tet-On 3G, with 10- to 100-fold increased sensitivity to doxycycline (Dox) compared with previous versions, enabling unusually sensitive on-off control of gene expression in vivo. Transgenic mice expressing Tet-On 3G were created using a new integrase-based, site-specific approach, yielding high-level transgene expression driven by a ubiquitous promoter. Blastocysts from these mice were transduced with the Tet-On 3G-response element promoter-driving firefly luciferase using lentivirus-mediated placenta-specific gene delivery and transferred into wild-type pseudopregnant recipients for placenta-specific, Dox-inducible gene expression. Systemic Dox administration at various time points during pregnancy led to transient, placenta-specific firefly luciferase expression as early as d 5 of pregnancy in a Dox dose-dependent manner. This system enables, for the first time, reliable pregnancy stage-specific induction of gene expression in the placenta and live monitoring of gene expression during pregnancy. It will be widely applicable to studies of both placental development and pregnancy, and the site-specific Tet-On G3 mouse will be valuable for studies in a broad range of tissues.

Treatment of IgA nephropathy using novel therapeutic strategy: Inflamed site specific gene delivery

Nephrology ◽  
2000 ◽  
Vol 5 (s1) ◽  
pp. A27-A27
Author(s):  
T Yokoo ◽  
Y Utsunomiya ◽  
T Imasawa ◽  
K Hirano ◽  
T Kawamura ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Iga Nephropathy ◽  
Therapeutic Strategy ◽  
Specific Gene ◽  
Site Specific ◽  
Novel Therapeutic

scholarly journals Site‐specific gene delivery to stented arteries using magnetically guided zinc oleate‐based nanoparticles loaded with adenoviral vectors

2013 ◽  
Vol 27 (6) ◽  
pp. 2198-2206 ◽  
Author(s):  
Michael Chorny ◽  
Ilia Fishbein ◽  
Jillian E. Tengood ◽  
Richard F. Adamo ◽  
Ivan S. Alferiev ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Adenoviral Vectors ◽  
Specific Gene ◽  
Site Specific

Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents

2006 ◽  
Vol 209 (2) ◽  
pp. 413-421 ◽  
Author(s):  
Candace M. Howard ◽  
Flemming Forsberg ◽  
Corrado Minimo ◽  
Ji-Bin Liu ◽  
Daniel A. Merton ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Contrast Agents ◽  
Delivery System ◽  
Adenoviral Vectors ◽  
Ultrasound Contrast Agents ◽  
Specific Gene ◽  
Gene Delivery System ◽  
Ultrasound Guided ◽  
Site Specific ◽  
Ultrasound Contrast
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