Permeation of Amphipathic Sweeteners into Taste-Bud Cells and Their Interactions with Post-Receptor Signaling Components: Possible Implications for Sweet-Taste Quality

2008 ◽  
pp. 241-255 ◽  
Author(s):  
M. Naim ◽  
M. E. Shaul ◽  
A. I. Spielman ◽  
L. Huang ◽  
I. Peri
Keyword(s):  
Sweet Taste ◽  
Taste Quality ◽  
Taste Bud ◽  
Receptor Signaling ◽  
Signaling Components ◽  
Taste Bud Cells

scholarly journals Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation

2021 ◽  
Vol 15 ◽  
Author(s):  
Elena von Molitor ◽  
Katja Riedel ◽  
Michael Krohn ◽  
Mathias Hafner ◽  
Rüdiger Rudolf ◽  
...  
Keyword(s):  
Alternative Pathway ◽  
Taste Receptor ◽  
Physiological Role ◽  
Primary Source ◽  
Sweet Taste ◽  
Receptor Expression ◽  
Taste Bud ◽  
Sweet Taste Receptor ◽  
The Brain ◽  
Taste Bud Cells

Sweetness is the preferred taste of humans and many animals, likely because sugars are a primary source of energy. In many mammals, sweet compounds are sensed in the tongue by the gustatory organ, the taste buds. Here, a group of taste bud cells expresses a canonical sweet taste receptor, whose activation induces Ca2+ rise, cell depolarization and ATP release to communicate with afferent gustatory nerves. The discovery of the sweet taste receptor, 20 years ago, was a milestone in the understanding of sweet signal transduction and is described here from a historical perspective. Our review briefly summarizes the major findings of the canonical sweet taste pathway, and then focuses on molecular details, about the related downstream signaling, that are still elusive or have been neglected. In this context, we discuss evidence supporting the existence of an alternative pathway, independent of the sweet taste receptor, to sense sugars and its proposed role in glucose homeostasis. Further, given that sweet taste receptor expression has been reported in many other organs, the physiological role of these extraoral receptors is addressed. Finally, and along these lines, we expand on the multiple direct and indirect effects of sugars on the brain. In summary, the review tries to stimulate a comprehensive understanding of how sweet compounds signal to the brain upon taste bud cells activation, and how this gustatory process is integrated with gastro-intestinal sugar sensing to create a hedonic and metabolic representation of sugars, which finally drives our behavior. Understanding of this is indeed a crucial step in developing new strategies to prevent obesity and associated diseases.

Co-expression of calcium signaling components in vertebrate taste bud cells

2000 ◽  
Vol 283 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Misaki Asano-Miyoshi ◽  
Keiko Abe ◽  
Yasufumi Emori
Keyword(s):  
Calcium Signaling ◽  
Taste Bud ◽  
Signaling Components ◽  
Taste Bud Cells

Some Observations on Changes in Denervated Taste Buds of Circumvallate Papillae of Rabbits

1969 ◽  
Vol 27 ◽  
pp. 308-309
Author(s):  
Sunao Fujimoto ◽  
Raymond G. Murray ◽  
Assia Murray
Keyword(s):  
Taste Buds ◽  
Taste Bud ◽  
Cell Type ◽  
Dark Cells ◽  
Type Iii ◽  
Circumvallate Papillae ◽  
Taste Bud Cells ◽  
Light Cells

Taste bud cells in circumvallate papillae of rabbit have been classified into three groups: dark cells; light cells; and type III cells. Unilateral section of the 9th nerve distal to the petrosal ganglion was performed in 18 animals, and changes of each cell type in the denervated buds were observed from 6 hours to 10 days after the operation.Degeneration of nerves is evident at 12 hours (Fig. 1) and by 2 days, nerves are completely lacking in the buds. Invasion by leucocytes into the buds is remarkable from 6 to 12 hours but then decreases. Their extrusion through the pore is seen. Shrinkage and disturbance in arrangement of cells in the buds can be seen at 2 days. Degenerated buds consisting of a few irregular cells and remnants of degenerated cells are present at 4 days, but buds apparently normal except for the loss of nerve elements are still present at 6 days.

scholarly journals Does intervention with GLP-1 receptor agonist semaglutide modulate perception of sweet taste in women with obesity: study protocol of a randomized, single-blinded, placebo-controlled clinical trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mojca Jensterle ◽  
Simona Ferjan ◽  
Tadej Battelino ◽  
Jernej Kovač ◽  
Saba Battelino ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Neural Response ◽  
Taste Perception ◽  
Taste Bud ◽  
Controlled Clinical Trial ◽  
Food Cues ◽  
Link Type ◽  
Visual Food Cues ◽  
Taste Bud Cells

Abstract Background Preclinical studies demonstrated that glucagon-like peptide 1 (GLP-1) is locally synthesized in taste bud cells and that GLP-1 receptor exists on the gustatory nerves in close proximity to GLP-1-containing taste bud cells. This local paracrine GLP-1 signalling seems to be specifically involved in the perception of sweets. However, the role of GLP-1 in taste perception remains largely unaddressed in clinical studies. Whether any weight-reducing effects of GLP-1 receptor agonists are mediated through the modulation of taste perception is currently unknown. Methods and analysis This is an investigator-initiated, randomized single-blind, placebo-controlled clinical trial. We will enrol 30 women with obesity and polycystic ovary syndrome (PCOS). Participants will be randomized in a 1:1 ratio to either semaglutide 1.0 mg or placebo for 16 weeks. The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry. Secondary endpoints include change in neural response to visual food cues and to sweet-tasting substances as assessed by functional MRI, change in body weight, change in fat mass and change in eating behaviour and food intake. Discussion This is the first study to investigate the role of semaglutide on taste perception, along with a neural response to visual food cues in reward processing regions. The study may identify the tongue and the taste perception as a novel target for GLP-1 receptor agonists. Ethics and disseminations The study has been approved by the Slovene National Medical Ethics Committee and will be conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. Results will be submitted for publication in an international peer-reviewed scientific journal. Trial registration ClinicalTrials.govNCT04263415. Retrospectively registered on 10 February 2020

Voltage-gated currents of taste bud cells in infant mice

2007 ◽  
Vol 58 ◽  
pp. S217
Author(s):  
Masafumi Iwamoto ◽  
Yoshitaka Ohtubo ◽  
Kiyonori Yoshii
Keyword(s):  
Taste Bud ◽  
Voltage Gated ◽  
Taste Bud Cells

Expression of Neurotrophic Factors and Their Receptors in Rat Posterior Taste Bud Cells

2014 ◽  
Vol 39 (2) ◽  
pp. 107-114
Author(s):  
Dong-Il Park ◽  
◽  
Ki-Myung Chung ◽  
Young-Kyung Cho ◽  
Kyung-Nyun Kim
Keyword(s):  
Neurotrophic Factors ◽  
Taste Bud ◽  
Taste Bud Cells

scholarly journals Spilanthol Enhances Sensitivity to Sodium in Mouse Taste Bud Cells

2018 ◽  
Vol 44 (2) ◽  
pp. 91-103 ◽  
Author(s):  
Jiang Xu ◽  
Brian C Lewandowski ◽  
Toshio Miyazawa ◽  
Yasutaka Shoji ◽  
Karen Yee ◽  
...  
Keyword(s):  
Taste Bud ◽  
Mouse Taste ◽  
Taste Bud Cells
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