Ultrafast Dynamics of Molecules in Intense Laser-Light Fields: New Research Directions

The small and medium-sized enterprises (SMEs) play a crucial part in county’s economic growth and a key contributor in country’s GDP. In Pakistan SMEs hold about 90 percent of the total businesses. The performance of SMEs depends upon many factors. The main aim for the research is to examine the relationship between Innovation Capability, Absorptive Capacity and Performance of SMEs in Pakistan. This conceptual paper also extends to the vague revelation on Business Strategy in which act as a moderator between Innovation Capability, Absorptive Capacity and SMEs Performance. Conclusively, this study proposes a new research directions and hypotheses development to examine the relationship among the variables in Pakistan’s SMEs context.

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MATERIAL HANDLING MACHINES AND SYSTEMS – UMI-TWINN PROJECT CONTRIBUTION

Advanced Logistic Systems - Theory and Practice ◽

10.32971/als.2019.001 ◽

2019 ◽

Vol 12 (1) ◽

pp. 7-20

Author(s):

Péter Telek ◽

Béla Illés ◽

Christian Landschützer ◽

Fabian Schenk ◽

Flavien Massi

Keyword(s):

Material Handling ◽

Digital Data ◽

Flow Process ◽

Research Directions ◽

Scientific Excellence ◽

Research Activities ◽

New Research ◽

Eu Project ◽

The University

Nowadays, the Industry 4.0 concept affects every area of the industrial, economic, social and personal sectors. The most significant changings are the automation and the digitalization. This is also true for the material handling processes, where the handling systems use more and more automated machines; planning, operation and optimization of different logistic processes are based on many digital data collected from the material flow process. However, new methods and devices require new solutions which define new research directions. In this paper we describe the state of the art of the material handling researches and draw the role of the UMi-TWINN partner institutes in these fields. As a result of this H2020 EU project, scientific excellence of the University of Miskolc can be increased and new research activities will be started.

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Antimicrobial and Amyloidogenic Activity of Peptides Synthesized on the Basis of the Ribosomal S1 Protein from Thermus Thermophilus

International Journal of Molecular Sciences ◽

10.3390/ijms21176382 ◽

2020 ◽

Vol 21 (17) ◽

pp. 6382 ◽

Cited By ~ 1

Author(s):

Stanislav Kurpe ◽

Sergei Grishin ◽

Alexey Surin ◽

Olga Selivanova ◽

Roman Fadeev ◽

...

Keyword(s):

Antimicrobial Activity ◽

Thermus Thermophilus ◽

Antibacterial Properties ◽

Cell Penetration ◽

Research Directions ◽

Bacterial Proteins ◽

Hiv Transcription ◽

Parent Protein ◽

Amyloidogenic Peptides ◽

New Research

Controlling the aggregation of vital bacterial proteins could be one of the new research directions and form the basis for the search and development of antibacterial drugs with targeted action. Such approach may be considered as an alternative one to antibiotics. Amyloidogenic regions can, like antibacterial peptides, interact with the “parent” protein, for example, ribosomal S1 protein (specific only for bacteria), and interfere with its functioning. The aim of the work was to search for peptides based on the ribosomal S1 protein from T. thermophilus, exhibiting both aggregation and antibacterial properties. The biological system of the response of Gram-negative bacteria T. thermophilus to the action of peptides was characterized. Among the seven studied peptides, designed based on the S1 protein sequence, the R23I (modified by the addition of HIV transcription factor fragment for bacterial cell penetration), R23T (modified), and V10I (unmodified) peptides have biological activity that inhibits the growth of T. thermophilus cells, that is, they have antimicrobial activity. But, only the R23I peptide had the most pronounced activity comparable with the commercial antibiotics. We have compared the proteome of peptide-treated and intact T. thermophilus cells. These important data indicate a decrease in the level of energy metabolism and anabolic processes, including the processes of biosynthesis of proteins and nucleic acids. Under the action of 20 and 50 μg/mL R23I, a decrease in the number of proteins in T. thermophilus cells was observed and S1 ribosomal protein was absent. The obtained results are important for understanding the mechanism of amyloidogenic peptides with antimicrobial activity and can be used to develop new and improved analogues.

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