Practical Convergent Synthesis of SERM 2

2002 ◽  
pp. 133-140
Author(s):  
Jeffery A. Dodge ◽  
Kathy K. Ellis ◽  
Lynne A. Hay ◽  
Thomas M. Koenig ◽  
Charles Lugar ◽  
...  
Keyword(s):  
Convergent Synthesis

A convergent synthesis of the spiroketal moiety of the HIV-1 protease inhibitors didemnaketals

Tetrahedron ◽  
2002 ◽  
Vol 58 (9) ◽  
pp. 1697-1708 ◽  
Author(s):  
Yan Xing Jia ◽  
Xin Li ◽  
Bin Wu ◽  
Xue Zhi Zhao ◽  
Yong Qiang Tu
Keyword(s):  
Protease Inhibitors ◽  
Convergent Synthesis ◽  
Hiv 1

Convergent Synthesis of Immune Inhibitor IMMH002

Synthesis ◽  
2020 ◽  
Author(s):  
Qiong Xiao ◽  
Si Chen ◽  
Zeyu Shi ◽  
Dali Yin
Keyword(s):  
Environmental Impact ◽  
Lewis Acid ◽  
Column Chromatography ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Convergent Synthesis ◽  
Quality Problem ◽  
Cross Coupling Reaction

AbstractA convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene is described with a key Suzuki–Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatography and solves the most intractable quality problem caused by a homologue by-product in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein is more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route.

Reducing-Agent-Free Convergent Synthesis of Hydroxyimino-Decorated Tetracyclic Fused Cinnolines via RhIII-Catalyzed Annulation Using Nitroolefins

2021 ◽  
Vol 86 (3) ◽  
pp. 2734-2747
Author(s):  
Pidiyara Karishma ◽  
Chikkagundagal K. Mahesha ◽  
Sanjay K. Mandal ◽  
Rajeev Sakhuja
Keyword(s):  
Reducing Agent ◽  
Convergent Synthesis

scholarly journals Stereoselective Convergent Synthesis of Carbon Skeleton of Cotylenin A Aglycone

Synthesis ◽  
2021 ◽  
Author(s):  
Kazuyuki Sugita ◽  
Motoi Kuwabara ◽  
Ami Matsuo ◽  
Shogo Kamo ◽  
Akinobu Matsuzawa
Keyword(s):  
Single Crystal ◽  
Aldol Reaction ◽  
Coupling Reaction ◽  
Carbon Skeleton ◽  
Convergent Synthesis ◽  
X Ray ◽  
Related Compounds

AbstractIn this paper, the synthesis of the carbon skeleton of cotylenin A aglycone is described. The key reactions, including an intramolecular aldol reaction, an aldol coupling reaction, and a ring-closing meta­thesis, allow for the effective and stereoselective access to the carbon skeleton of cotylenin A aglycone. The stereochemistry was confirmed by single-crystal X-ray crystallographic analyses of related compounds.

A New and Convergent Synthesis for 2,5-Diamino-tetrahydropyrimidones.

ChemInform ◽  
2003 ◽  
Vol 34 (26) ◽  
Author(s):  
Lianhong Xu ◽  
Lijun Zhang ◽  
Clifford M. Bryant ◽  
Choung U. Kim
Keyword(s):  
Convergent Synthesis

A Convergent Synthesis of CGS23305, A Thromboxane Synthase Inhibitor

Synthesis ◽  
1999 ◽  
Vol 1999 (05) ◽  
pp. 769-774 ◽  
Author(s):  
Andrew T. Bach ◽  
John A. Carlson ◽  
Peter P. Giannousis
Keyword(s):  
Thromboxane Synthase ◽  
Convergent Synthesis ◽  
Thromboxane Synthase Inhibitor ◽  
Synthase Inhibitor
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