Fractional Factorial Approaches to Emmaqua Experiments

2001 ◽  
pp. 63-88 ◽  
Author(s):  
Henry K. Hardcastle
Keyword(s):  
Fractional Factorial

Optimization of PES Nanocomposite Membrane Preparation Using Statistical Analysis and Experimental Design

2019 ◽  
Author(s):  
Yasin Orooji ◽  
Fatemeh Noorisafa ◽  
Nahid Imami ◽  
Amir R. Chaharmahali
Keyword(s):  
Statistical Analysis ◽  
Experimental Design ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Fractional Factorial ◽  
Nanocomposite Membrane ◽  
Membrane Preparation ◽  
Membrane Fabrication

<p>Using experimental design and statistical analysis (½ Fractional Factorial Design), this study investigates the effect of different parameters in the membrane fabrication on the performance of nanocomposite PES/TiO<sub>2</sub> membrane. </p>

Are More Profiles Better Than Fewer?: Searching for Parsimony and Relevance in Stated Choice Experiments

2000 ◽  
Vol 1719 (1) ◽  
pp. 165-174 ◽  
Author(s):  
Peter R. Stopher ◽  
David A. Hensher
Keyword(s):  
New Zealand ◽  
Degrees Of Freedom ◽  
Choice Model ◽  
Fractional Factorial ◽  
Sources Of Information ◽  
Stated Choice ◽  
Complex Design ◽  
Data Collection Instrument ◽  
Main Effects ◽  
Better Than

Transportation planners increasingly include a stated choice (SC) experiment as part of the armory of empirical sources of information on how individuals respond to current and potential travel contexts. The accumulated experience with SC data has been heavily conditioned on analyst prejudices about the acceptable complexity of the data collection instrument, especially the number of profiles (or treatments) given to each sampled individual (and the number of attributes and alternatives to be processed). It is not uncommon for transport demand modelers to impose stringent limitations on the complexity of an SC experiment. A review of the marketing and transport literature suggests that little is known about the basis for rejecting complex designs or accepting simple designs. Although more complex designs provide the analyst with increasing degrees of freedom in the estimation of models, facilitating nonlinearity in main effects and independent two-way interactions, it is not clear what the overall behavioral gains are in increasing the number of treatments. A complex design is developed as the basis for a stated choice study, producing a fractional factorial of 32 rows. The fraction is then truncated by administering 4, 8, 16, 24, and 32 profiles to a sample of 166 individuals (producing 1, 016 treatments) in Australia and New Zealand faced with the decision to fly (or not to fly) between Australia and New Zealand by either Qantas or Ansett under alternative fare regimes. Statistical comparisons of elasticities (an appropriate behavioral basis for comparisons) suggest that the empirical gains within the context of a linear specification of the utility expression associated with each alternative in a discrete choice model may be quite marginal.

Synthesis of Functionalized Magnetite Titanium Dioxide Nanocomposite for Removal of Acid Fuchsine Dye

2018 ◽  
Vol 21 (8) ◽  
pp. 583-593 ◽  
Author(s):  
Sara Rahnama ◽  
Shahab Shariati ◽  
Faten Divsar
Keyword(s):  
Titanium Dioxide ◽  
Removal Efficiency ◽  
Magnetic Core ◽  
Fractional Factorial ◽  
Order Kinetic ◽  
Sorption Data ◽  
Salt Addition ◽  
Order Kinetic Model ◽  
Pseudo Second Order ◽  
Ft Ir

Objective: In this research, a novel magnetite titanium dioxide nanocomposite functionalized by amine groups (Fe3O4@SiO2@TiO2-NH2) was synthesized and its ability for efficient removal of Acid Fuchsine as an anionic dye from aqueous solutions was investigated. Method: The core-shell structure of Fe3O4@SiO2@TiO2 was prepared using Fe3O4 as magnetic core, tetra ethyl orthosilicate as silica and tetra butyl titanate as titanium source for shell. The synthesized nanocomposites (particle size lower than 44 nm) were characterized by FT-IR, XRD, DRS, SEM and TGA instruments. The various experimental parameters affecting dye removal efficiency were investigated and optimized using Taguchi fractional factorial design. Results: The synthesized adsorbent showed the highest removal efficiency of Acid Fuchsine (99 %) at pH= 3.5, without salt addition and during stirring at contact times less than 10 minutes. The study of kinetic models at two concentration levels showed the fast dye sorption on the surface of proposed nanocomposites with pseudo second order kinetic model (R2=1). Also, the fitting of Acid Fuchsine sorption data to Freundlich, Langmuir and Temkin isotherms suggested that Freundlich model gave a better fitting than other models (R2=0.9936, n=2). Conclusion: Good chemical stability, excellent magnetic properties, very fast adsorption kinetics and high removal efficiency make the synthesized nanocomposite as a proper recoverable sorbent for removal of Acid Fuchsine dye from wastewaters.

Study of 5-Fluorouracil Loaded Chitosan Nanoparticles for Treatment of Skin Cancer

2020 ◽  
Vol 14 (3) ◽  
pp. 210-224
Author(s):  
Gayatri Patel ◽  
Bindu K.N. Yadav
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Chitosan Nanoparticles ◽  
Entrapment Efficiency ◽  
Fractional Factorial ◽  
Spherical Particles

Background: The purpose of this study was to formulate, characterize and in-vitro cytotoxicity of 5-Fluorouracil loaded controlled release nanoparticles for the treatment of skin cancer. The patents on nanoparticles (US8414926B1), (US61654404A), (WO2007150075A3) etc. helped in the selection polymers and method for the preparation of nanoparticles. Methods: In the present study nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and sodium tripolyphosphate (TPP). Several process and formulation parameters were screened and optimized using 25-2 fractional factorial design. The prepared nanoparticles were evaluated for particle size, shape, charge, entrapment efficiency, crosslinking mechanism and drug release study. Results: The optimized 5-Fluorouracil loaded nanoparticle were found with particle size of of 320±2.1 nm, entrapment efficiency of 85.12%± 1.1% and Zeta potential of 29mv±1mv. Scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The invitro release profile showed controlled release up to 24 hr. Further study was carried using A375 basal cell carcinoma cell-line to elucidate the mechanism of its cytotoxicity by MTT assay. Conclusion: These results demonstrate that the possibility of delivering 5-Fluorouracil to skin with enhanced encapsulation efficiency indicating effectiveness of the formulation for treatment of basal cell carcinoma type of skin cancer.

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