A New Method for the Detection and Measurement of Polyaromatic Carcinogens and Related Compounds by DNA Intercalation

1996 ◽  
pp. 44-60 ◽  
Author(s):  
John J. Horvath ◽  
Manana Gueguetchkeri ◽  
Adarsh Gupta ◽  
Devi Penumatchu ◽  
Howard H. Weetall
Keyword(s):  
New Method ◽  
Dna Intercalation ◽  
Related Compounds

ChemInform Abstract: A NEW METHOD FOR RESOLUTION OF RACEMIC FORMS OF α-AMINO ACIDS AND RELATED COMPOUNDS

1976 ◽  
Vol 7 (29) ◽  
pp. no-no
Author(s):  
A. M. OSMAN ◽  
M. A. EL-MAGHRABY ◽  
K. M. HASSAN
Keyword(s):  
Amino Acids ◽  
New Method ◽  
Related Compounds

A NEW METHOD OF PREPARING DIBENZOYL ETHYLENE AND RELATED COMPOUNDS

1923 ◽  
Vol 45 (5) ◽  
pp. 1303-1307 ◽  
Author(s):  
James B. Conant ◽  
Robert E. Lutz
Keyword(s):  
New Method ◽  
Related Compounds

ChemInform Abstract: AMINO ACIDS AND PEPTIDES. II. NEW METHOD FOR PREPARING DIAZODIPHENYLMETHANE AND RELATED COMPOUNDS

1976 ◽  
Vol 7 (3) ◽  
pp. no-no
Author(s):  
J. ROBERT ADAMSON ◽  
ROY BYWOOD ◽  
DAVID T. EASTLICK ◽  
GERARD GALLAGHER ◽  
DEREK WALKER ◽  
...  
Keyword(s):  
Amino Acids ◽  
New Method ◽  
Related Compounds

Amino-acids and peptides. Part II. A new method for preparing diazodiphenylmethane and related compounds

1975 ◽  
pp. 2030 ◽  
Author(s):  
J. Robert Adamson ◽  
Roy Bywood ◽  
David T. Eastlick ◽  
Gerard Gallagher ◽  
Derek Walker ◽  
...  
Keyword(s):  
Amino Acids ◽  
New Method ◽  
Related Compounds

New Methods for the Synthesis of Troponoid Compounds

1991 ◽  
Vol 44 (1) ◽  
pp. 1 ◽  
Author(s):  
MG Banwell
Keyword(s):  
Natural Products ◽  
Ring Expansion ◽  
Biologically Active ◽  
New Method ◽  
New Methods ◽  
Carbocyclic Compounds ◽  
Related Compounds

The ring expansion of 7-halogenobicyclo[4.1.0] heptenones and related compounds provides a useful new method for the preparation of the seven-membered conjugated carbocyclic compounds known as tropones and tropolones. This methodology has been exploited in the synthesis of various biologically active troponoid natural products including nezukone, the thujaplicins, thujaplicinol, MY3-469 and colchicine.

scholarly journals Molecular Networking Reveals Two Distinct Chemotypes in Pyrroloiminoquinone-Producing Tsitsikamma favus Sponges

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 60 ◽  
Author(s):  
Jarmo-Charles Kalinski ◽  
Samantha Waterworth ◽  
Xavier Siwe Noundou ◽  
Meesbah Jiwaji ◽  
Shirley Parker-Nance ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biosynthetic Pathway ◽  
Dna Intercalation ◽  
Chemical Characteristics ◽  
Taxonomic Identification ◽  
Human Cell Lines ◽  
Molecular Networking ◽  
Drug Leads ◽  
Related Compounds ◽  
Chromatographic Isolation

The temperate marine sponge, Tsitsikamma favus, produces pyrroloiminoquinone alkaloids with potential as anticancer drug leads. We profiled the secondary metabolite reservoir of T. favus sponges using HR-ESI-LC-MS/MS-based molecular networking analysis followed by preparative purification efforts to map the diversity of new and known pyrroloiminoquinones and related compounds in extracts of seven specimens. Molecular taxonomic identification confirmed all sponges as T. favus and five specimens (chemotype I) were found to produce mainly discorhabdins and tsitsikammamines. Remarkably, however, two specimens (chemotype II) exhibited distinct morphological and chemical characteristics: the absence of discorhabdins, only trace levels of tsitsikammamines and, instead, an abundance of unbranched and halogenated makaluvamines. Targeted chromatographic isolation provided the new makaluvamine Q, the known makaluvamines A and I, tsitsikammamine B, 14-bromo-7,8-dehydro-3-dihydro-discorhabdin C, and the related pyrrolo-ortho-quinones makaluvamine O and makaluvone. Purified compounds displayed different activity profiles in assays for topoisomerase I inhibition, DNA intercalation and antimetabolic activity against human cell lines. This is the first report of makaluvamines from a Tsitsikamma sponge species, and the first description of distinct chemotypes within a species of the Latrunculiidae family. This study sheds new light on the putative pyrroloiminoquinone biosynthetic pathway of latrunculid sponges.

scholarly journals A New Method of Synthesizing 7-(2-Hydroxy-5-oxo-1-cyclopentenyl)heptanoic Acid and Related Compounds

1988 ◽  
Vol 61 (7) ◽  
pp. 2401-2404 ◽  
Author(s):  
Hirokazu Naora ◽  
Takashi Ohnuki ◽  
Asao Nakamura
Keyword(s):  
New Method ◽  
Heptanoic Acid ◽  
Related Compounds
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