scholarly journals Adenovirus-Mediated Overexpression of Microsomal Triglyceride Transfer Protein (MTP):  Mechanistic Studies on the Role of MTP in Apolipoprotein B-100 Biogenesis, by

Biochemistry ◽  
1999 ◽  
Vol 38 (31) ◽  
pp. 10215-10215 ◽  
Author(s):  
Wei Liao ◽  
Kunihisa Kobayashi ◽  
Lawrence Chan
Keyword(s):  
Apolipoprotein B ◽  
Microsomal Triglyceride Transfer Protein ◽  
Mechanistic Studies ◽  
Transfer Protein

Development and Physiological Regulation of Intestinal Lipid Absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion

2007 ◽  
Vol 293 (3) ◽  
pp. G519-G524 ◽  
Author(s):  
Dennis D. Black
Keyword(s):  
Dietary Fat ◽  
Apolipoprotein B ◽  
Microsomal Triglyceride Transfer Protein ◽  
Lipid Absorption ◽  
Cellular Mechanisms ◽  
Peripheral Tissues ◽  
Physiological Regulation ◽  
Transfer Protein ◽  
Cellular Events ◽  
Apolipoprotein A

The newborn mammal must efficiently absorb dietary fat, predominantly as triacylglycerol, and produce chylomicrons to deliver this lipid to peripheral tissues. The cellular mechanisms involved in enterocyte chylomicron assembly have recently been elucidated, and data on their regulation in the immature gut are beginning to emerge. This review focuses on key proteins involved in chylomicron assembly: apolipoprotein B-48, microsomal triglyceride transfer protein, and apolipoproten A-IV. Recent studies support a role for apolipoprotein A-IV in enhancing chylomicron secretion by promoting production of larger particles. These proteins are regulated in a manner to maximize the lipid absorptive capacity of the newborn intestine.

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