Identification of the Carbonic Anhydrase II Binding Site in the Cl-/HCO3-Anion Exchanger AE1†

Biochemistry ◽  
2000 ◽  
Vol 39 (18) ◽  
pp. 5527-5533 ◽  
Author(s):  
John W. Vince ◽  
Reinhart A. F. Reithmeier
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Site ◽  
Anion Exchanger ◽  
Carbonic Anhydrase Ii

Localization of the Cl-/HCO3-Anion Exchanger Binding Site to the Amino-Terminal Region of Carbonic Anhydrase II†

Biochemistry ◽  
2000 ◽  
Vol 39 (44) ◽  
pp. 13344-13349 ◽  
Author(s):  
John W. Vince ◽  
Uno Carlsson ◽  
Reinhart A. F. Reithmeier
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Site ◽  
Anion Exchanger ◽  
Terminal Region ◽  
Carbonic Anhydrase Ii ◽  
Amino Terminal

Effect of the hydrogen bond network in carbonic anhydrase II zinc binding site. A theoretical study

1998 ◽  
Vol 76 (7) ◽  
pp. 1027-1032 ◽  
Author(s):  
Silvia Álvarez-Santos ◽  
Àngels González-Lafont ◽  
José M Lluch
Keyword(s):  
Hydrogen Bond ◽  
Carbonic Anhydrase ◽  
Binding Site ◽  
Zinc Binding ◽  
Carbonic Anhydrase Ii ◽  
Am1 Method ◽  
Hydrogen Bond Network ◽  
Zinc Binding Site ◽  
Bond Network ◽  
Metal Ligand

The hydrogen bond network influence on the carbonic anhydrase II (CAII) zinc binding site has been studied theoretically by using the semiempirical AM1 method. To this aim, quantum mechanical reduced models of wild-type CAII and several CAII variants have been constructed. We have shown that, when a direct metal ligand donates a hydrogen bond to an indirect metal ligand, the first-shell residues enhance their electrostatic interaction with the zinc cation. Thus, the hydrogen-bond network is able to modulate the zinc binding affinity and the zinc-water pKa.Key words: hydrogen bond network, carbonic anhydrase II, Zn2+ metalloenzyme ligands.

Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II

Biochemistry ◽  
1993 ◽  
Vol 32 (38) ◽  
pp. 9896-9900 ◽  
Author(s):  
Laura L. Kiefer ◽  
Joseph F. Krebs ◽  
Steven A. Paterno ◽  
Carol A. Fierke
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Site ◽  
Zinc Binding ◽  
Carbonic Anhydrase Ii ◽  
Zinc Binding Site ◽  
Human Carbonic Anhydrase

A Novel Carbonic Anhydrase II Binding Site Regulates NHE1 Activity†

Biochemistry ◽  
2006 ◽  
Vol 45 (7) ◽  
pp. 2414-2424 ◽  
Author(s):  
Xiuju Li ◽  
Yongsheng Liu ◽  
Bernardo V. Alvarez ◽  
Joseph R. Casey ◽  
Larry Fliegel
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Site ◽  
Carbonic Anhydrase Ii ◽  
Nhe1 Activity

Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Nonsteroidal Inhibitors,

Biochemistry ◽  
2010 ◽  
Vol 49 (16) ◽  
pp. 3464-3476 ◽  
Author(s):  
Gyles E. Cozier ◽  
Mathew P. Leese ◽  
Matthew D. Lloyd ◽  
Matthew D. Baker ◽  
Nethaji Thiyagarajan ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Binding Site ◽  
Carbonic Anhydrase Ii ◽  
Human Carbonic Anhydrase

scholarly journals Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1

2013 ◽  
Vol 591 (20) ◽  
pp. 4963-4982 ◽  
Author(s):  
Samer Al-Samir ◽  
Symeon Papadopoulos ◽  
Renate J. Scheibe ◽  
Joachim D. Meißner ◽  
Jean-Pierre Cartron ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Anion Exchanger ◽  
Carbonic Anhydrase Ii ◽  
Transport Activity
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