Identification of the Sites of Hydroxyl Radical Reaction with Peptides by Hydrogen/Deuterium Exchange:  Prevalence of Reactions with the Side Chains†

Michael B. Goshe; Yong Hong Chen; Vernon E. Anderson

doi:10.1021/bi991569j

Identification of the Sites of Hydroxyl Radical Reaction with Peptides by Hydrogen/Deuterium Exchange: Prevalence of Reactions with the Side Chains†

Biochemistry ◽

10.1021/bi991569j ◽

2000 ◽

Vol 39 (7) ◽

pp. 1761-1770 ◽

Cited By ~ 51

Author(s):

Michael B. Goshe ◽

Yong Hong Chen ◽

Vernon E. Anderson

Keyword(s):

Hydroxyl Radical ◽

Radical Reaction ◽

Deuterium Exchange ◽

Side Chains ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium

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Hydroxyl Radical-Induced Hydrogen/Deuterium Exchange in Amino Acid Carbon-Hydrogen Bonds

Radiation Research ◽

10.2307/3579746 ◽

1999 ◽

Vol 151 (1) ◽

pp. 50 ◽

Cited By ~ 13

Author(s):

Michael B. Goshe ◽

Vernon E. Anderson

Keyword(s):

Amino Acid ◽

Hydrogen Bonds ◽

Hydroxyl Radical ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

Carbon Hydrogen Bonds

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Characterization of individual tryptophan side chains in proteins using Raman spectroscopy and hydrogen-deuterium exchange kinetics

Biochemistry ◽

10.1021/bi00401a015 ◽

1988 ◽

Vol 27 (1) ◽

pp. 88-94 ◽

Cited By ~ 154

Author(s):

Takashi Miura ◽

Hideo Takeuchi ◽

Issei Harada

Keyword(s):

Raman Spectroscopy ◽

Deuterium Exchange ◽

Side Chains ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium ◽

Exchange Kinetics ◽

Tryptophan Side Chains

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Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-019-02316-1 ◽

2019 ◽

Vol 30 (12) ◽

pp. 2795-2804 ◽

Cited By ~ 1

Author(s):

Ke Sherry Li ◽

Elizabeth T. Schaper Bergman ◽

Brett R. Beno ◽

Richard Y.-C. Huang ◽

Ekaterina Deyanova ◽

...

Keyword(s):

Hydroxyl Radical ◽

Small Molecule ◽

Hydrophobic Interactions ◽

Small Molecule Inhibitor ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Molecule Inhibitor ◽

Hydrogen Deuterium ◽

Hydroxyl Radical Footprinting

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Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Alkali metal ion-induced conformation changes of methionine- and leucine enkephalin investigated by gas-phase hydrogen/deuterium exchange combined with theoretical calculations

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.130113 ◽

2021 ◽

Vol 1233 ◽

pp. 130113

Author(s):

Fangling Wu ◽

Yizhen Wang ◽

Yinjuan Chen ◽

Zhenhua Li ◽

Chuan-Fan Ding

Keyword(s):

Alkali Metal ◽

Gas Phase ◽

Metal Ion ◽

Theoretical Calculations ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Alkali Metal Ion ◽

Leucine Enkephalin ◽

Conformation Changes ◽

Hydrogen Deuterium

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Calculation of reaction rate constants for hydrogen–deuterium exchange reactions of methane catalysed by acid zeolites

Chemical Communications ◽

10.1039/b102249k ◽

2001 ◽

pp. 1108-1109 ◽

Cited By ~ 6

Author(s):

Ann M. Vos ◽

Robert A. Schoonheydt ◽

Frank De Proft ◽

Paul Geerlings

Keyword(s):

Rate Constants ◽

Reaction Rate ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Reactions ◽

Reaction Rate Constants ◽

Acid Zeolites ◽

Hydrogen Deuterium

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A simple method for differentiation of monoisotopic drug metabolites with hydrogen–deuterium exchange liquid chromatography/electrospray mass spectrometry

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.02.005 ◽

2005 ◽

Vol 25 (1) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

Ari Tolonen ◽

Miia Turpeinen ◽

Jouko Uusitalo ◽

Olavi Pelkonen

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Electrospray Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Simple Method ◽

Drug Metabolites ◽

Hydrogen Deuterium

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Ab initio molecular dynamics study of the hydrogen-deuterium exchange in bulk lithiumborohydride (LiBH4)

Applied Physics Letters ◽

10.1063/1.3115032 ◽

2009 ◽

Vol 94 (14) ◽

pp. 141903 ◽

Cited By ~ 12

Author(s):

M. Ramzan ◽

R. Ahuja

Keyword(s):

Molecular Dynamics ◽

Ab Initio ◽

Deuterium Exchange ◽

Ab Initio Molecular Dynamics ◽

Hydrogen Deuterium Exchange ◽

Hydrogen Deuterium

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Use of 1,5-diaminonaphthalene to combine matrix-assisted laser desorption/ionization in-source decay fragmentation with hydrogen/deuterium exchange

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6627 ◽

2013 ◽

Vol 27 (16) ◽

pp. 1837-1846 ◽

Cited By ~ 11

Author(s):

Pascale Lemaire ◽

Delphine Debois ◽

Nicolas Smargiasso ◽

Loïc Quinton ◽

Valérie Gabelica ◽

...

Keyword(s):

Laser Desorption ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Laser Desorption Ionization ◽

Desorption Ionization ◽

Hydrogen Deuterium ◽

Matrix Assisted Laser ◽

Matrix Assisted Laser Desorption

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Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Cited By ~ 4

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Continuous Feeding

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