Role of the Loop Containing Residue 115 in the Induced-Fit Mechanism of the Bacterial Cell Wall Biosynthetic Enzyme MurA‡

Biochemistry ◽  
2000 ◽  
Vol 39 (9) ◽  
pp. 2164-2173 ◽  
Author(s):  
Ernst Schönbrunn ◽  
Susanne Eschenburg ◽  
Florian Krekel ◽  
Karolin Luger ◽  
Nikolaus Amrhein
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Biosynthetic Enzyme ◽  
Induced Fit

Role of bacterial cell wall proteinase in antihypertension

2002 ◽  
Vol 22 (1-2) ◽  
pp. 209-222 ◽  
Author(s):  
Bénédicte Flambard
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall

Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation

1991 ◽  
Vol 260 (2) ◽  
pp. G213-G219 ◽  
Author(s):  
R. A. DeLa Cadena ◽  
K. J. Laskin ◽  
R. A. Pixley ◽  
R. B. Sartor ◽  
J. H. Schwab ◽  
...  
Keyword(s):  
Cell Wall ◽  
Acute Phase ◽  
Bacterial Cell ◽  
Chronic Phase ◽  
Bacterial Cell Wall ◽  
Kinin System ◽  
Kallikrein Kinin System ◽  
Bacterial Products

The plasma kallikrein-kinin system is activated in Gram-negative sepsis and typhoid fever, two diseases in which bacterial products have been shown to initiate inflammation. Because a single intraperitoneal injection of bacterial cell wall peptidoglycan-polysaccharide polymers from group A steptococci (PG-APS) into a Lewis rat produces a syndrome of relapsing polyarthritis and anemia, we investigated changes in the role of the kallikrein-kinin system in this model of inflammation. Coagulation studies after injection of PG-APS revealed an immediate and persistent decrease in prekallikrein levels. High-molecular-weight kininogen levels decreased significantly during the acute phase and correlated with the severity of arthritis. Factor XI levels were decreased only during the acute phase. Antithrombin III levels remained unchanged, indicating that neither decreased hepatic synthesis nor disseminated intravascular coagulation caused the decreased plasma contact factors. Plasma T-kininogen (an acute phase protein) was significantly elevated during the chronic phase. PG-APS failed to activate the contact system in vitro. Thus the kallikrein-kinin system plays an important role in this experimental model of inflammation, suggesting that activation of this system may play a role in the pathogenesis of inflammatory bowel disease and rheumatoid arthritis in which bacterial products might be etiologically important.

scholarly journals The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),

Biochemistry ◽  
2010 ◽  
Vol 49 (19) ◽  
pp. 4276-4282 ◽  
Author(s):  
Huijong Han ◽  
Yan Yang ◽  
Sanne H. Olesen ◽  
Andreas Becker ◽  
Stephane Betzi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Biosynthetic Enzyme ◽  
Covalent Inhibitor

scholarly journals The importance of being cross-linked for the bacterial cell wall

2019 ◽  
Author(s):  
Garima Rani ◽  
Issan Patri
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Turgor Pressure ◽  
Length Distribution ◽  
Peptide Bond ◽  
Vital Role ◽  
Bacterial Cell Wall ◽  
Cross Linking ◽  
Strand Length

AbstractThe bacterial cell wall is primarily composed of a mesh of stiff glycan strands cross-linked by peptide bridges and is essential for safeguarding the cell. The structure of the cell wall has to be stiff enough to bear the high turgor pressure and sufficiently tough to ensure protection against failure. Here we explore the role of various design features of the cell in enhancing the toughness of the cell wall. We explain how the glycan strand length distribution and the degree of cross-linking can play a vital role in ensuring that the cell wall offers sufficient resistance to propagation of cracks. We suggest a possible mechanism by which peptide bond hydrolysis can also help mitigate this risk of failure. We also study the reinforcing effect of MreB on the cell wall and conclude that the cross-linked structure of the cell wall plays the more important role in safeguarding against mechanical failure due to cracking.

scholarly journals The role of hydrolases in bacterial cell-wall growth

2013 ◽  
Vol 16 (6) ◽  
pp. 760-766 ◽  
Author(s):  
Timothy K Lee ◽  
Kerwyn Casey Huang
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Growth ◽  
Wall Growth

scholarly journals The role of bacterial cell wall hydrophobicity in adhesion.

1987 ◽  
Vol 53 (8) ◽  
pp. 1893-1897 ◽  
Author(s):  
M C van Loosdrecht ◽  
J Lyklema ◽  
W Norde ◽  
G Schraa ◽  
A J Zehnder
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall

scholarly journals The role of bacterial cell wall dimers in the innate immune response (970.1)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Lauren Genova ◽  
James Melnyk ◽  
Vishnu Mohanan ◽  
Catherine Grimes
Keyword(s):  
Immune Response ◽  
Cell Wall ◽  
Innate Immune Response ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Innate Immune

Role of Liver Macrophages (Kupffer Cells) in Bacterial Cell Wall-Induced Hepatic Inflammation

1993 ◽  
pp. 523-526
Author(s):  
T. Kossmann ◽  
C. Manthey ◽  
J. B. Allen ◽  
C. Morganti-Kossmann ◽  
K. Ohura ◽  
...  
Keyword(s):  
Cell Wall ◽  
Kupffer Cells ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Hepatic Inflammation ◽  
Liver Macrophages
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