Roles of Active Site Aromatic Residues in Catalysis by Ketosteroid Isomerase fromPseudomonas putidaBiotype B†

Biochemistry ◽  
1999 ◽  
Vol 38 (42) ◽  
pp. 13810-13819 ◽  
Author(s):  
Do-Hyung Kim ◽  
Gyu Hyun Nam ◽  
Do Soo Jang ◽  
Gildon Choi ◽  
Soyoung Joo ◽  
...  
Keyword(s):  
Active Site ◽  
Ketosteroid Isomerase ◽  
Aromatic Residues

scholarly journals Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni.

1982 ◽  
Vol 257 (21) ◽  
pp. 12589-12593
Author(s):  
T M Penning ◽  
D N Heller ◽  
T M Balasubramanian ◽  
C C Fenselau ◽  
P Talalay
Keyword(s):  
Active Site ◽  
Mass Spectrometric ◽  
Ketosteroid Isomerase ◽  
Pseudomonas Testosteroni

scholarly journals Globally Optimized Molecular Embeddings for Dynamic Reaction Solvate Shell Optimization and Active Site Design

2021 ◽  
Author(s):  
Dominik M. Behrens ◽  
Bernd Hartke
Keyword(s):  
Global Optimization ◽  
Active Site ◽  
Solvate Shell ◽  
Dynamic Reaction ◽  
Ketosteroid Isomerase ◽  
Recent Interest ◽  
Site Design ◽  
Shell Optimization

AbstractWe demonstrate how a full QM/MM derivatization of the recently developed GOCAT model can be utilized in the global optimization of molecular embeddings. To this end, we provide two distinct examples: An $$\text {S}_\text {N}2$$ S N 2 reaction, and one enzymatic example of recent interest, the ketosteroid isomerase. These serve us to highlight the advantages of such an approach and sketch the roadmap for further improvements.

Flexibility of active-site gorge aromatic residues and non-gorge aromatic residues in acetylcholinesterase

2013 ◽  
Vol 67 (7) ◽  
Author(s):  
Pavan GhattyVenkataKrishna ◽  
Neelima Chavali ◽  
Edward Uberbacher
Keyword(s):  
Active Site ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Cross Sectional ◽  
Aromatic Residues

AbstractThe presence of an unusually large number of aromatic residues in the active site gorge of acetylcholinesterase is a subject of great interest. Flexibility of these residues has been suspected to be a key player in controlling the ligand traversal in the gorge. This raises the question of whether the over-representation of aromatic residues in the gorge implies higher-than-normal flexibility of these residues. The current study suggests that it does not. Large changes in the hydrophobic cross-sectional area due to dihedral oscillations are probably the reason of their presence in the gorge.

Mutations on Aromatic Residues of the Active Site To Alter Selectivity of theSulfolobus solfataricusMaltooligosyltrehalose Synthase

2006 ◽  
Vol 54 (10) ◽  
pp. 3585-3590 ◽  
Author(s):  
Tsuei-Yun Fang ◽  
Wen-Chi Tseng ◽  
Yao-Te Chung ◽  
Ching-Hsing Pan
Keyword(s):  
Active Site ◽  
Aromatic Residues

Site-directed mutagenesis studies of the aromatic residues at the active site of a lipase from Malassezia globosa

Biochimie ◽  
2014 ◽  
Vol 102 ◽  
pp. 29-36 ◽  
Author(s):  
Chongliang Gao ◽  
Dongming Lan ◽  
Lu Liu ◽  
Houjin Zhang ◽  
Bo Yang ◽  
...  
Keyword(s):  
Active Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Aromatic Residues ◽  
Malassezia Globosa

Catalytic mechanism of an active-site mutant (D38N) of .DELTA.5-3-ketosteroid isomerase

Biochemistry ◽  
1991 ◽  
Vol 30 (20) ◽  
pp. 4991-4997 ◽  
Author(s):  
Liang Xue ◽  
Athan Kuliopulos ◽  
Albert S. Mildvan ◽  
Paul Talalay
Keyword(s):  
Active Site ◽  
Catalytic Mechanism ◽  
Ketosteroid Isomerase

scholarly journals Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site

2013 ◽  
Vol 110 (28) ◽  
pp. E2552-E2561 ◽  
Author(s):  
P. A. Sigala ◽  
A. T. Fafarman ◽  
J. P. Schwans ◽  
S. D. Fried ◽  
T. D. Fenn ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Proton Transfer ◽  
Active Site ◽  
Ketosteroid Isomerase
Sign in / Sign up

Export Citation Format

Share Document