Dynamic Mobility of Genetically Expressed Fusion Protein between Cytochrome P4501A1 and NADPH−Cytochrome P450 Reductase in Yeast Microsomes

Makoto Yamada; Yoshihiro Ohta; Toshiyuki Sakaki; Yoshiyasu Yabusaki; Hideo Ohkawa; Suguru Kawato

doi:10.1021/bi990648s

Dynamic Mobility of Genetically Expressed Fusion Protein between Cytochrome P4501A1 and NADPH−Cytochrome P450 Reductase in Yeast Microsomes

Biochemistry ◽

10.1021/bi990648s ◽

1999 ◽

Vol 38 (29) ◽

pp. 9465-9470 ◽

Cited By ~ 5

Author(s):

Makoto Yamada ◽

Yoshihiro Ohta ◽

Toshiyuki Sakaki ◽

Yoshiyasu Yabusaki ◽

Hideo Ohkawa ◽

...

Keyword(s):

Cytochrome P450 ◽

Fusion Protein ◽

Cytochrome P450 Reductase ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Dynamic Mobility ◽

Nadph Cytochrome P450 Reductase

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Mutagenesis Study of Asp-290 in Cytochrome P450 2B11 Using a Fusion Protein with Rat NADPH-Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1996.0050 ◽

1996 ◽

Vol 326 (1) ◽

pp. 85-92 ◽

Cited By ~ 26

Author(s):

Greg R. Harlow ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Fusion Protein ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase ◽

Mutagenesis Study

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Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with NADPH–Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2000.2174 ◽

2001 ◽

Vol 385 (2) ◽

pp. 290-300 ◽

Cited By ~ 9

Author(s):

Tomas Cvrk ◽

Henry W. Strobel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700817 ◽

2005 ◽

Vol 12 (5) ◽

pp. 497-508 ◽

Cited By ~ 25

Author(s):

Marina Tychopoulos ◽

Laurent Corcos ◽

Philippe Genne ◽

Philippe Beaune ◽

Isabelle de Waziers

Keyword(s):

Lung Cancer ◽

Cytochrome P450 ◽

Fusion Protein ◽

Cytochrome P450 Reductase ◽

Enzyme Prodrug Therapy ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Expression, Purification, and Biochemical Characterization of A Human Cytochrome P450 CYP2D6-NADPH Cytochrome P450 Reductase Fusion Protein

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2001.2585 ◽

2001 ◽

Vol 396 (1) ◽

pp. 16-24 ◽

Cited By ~ 23

Author(s):

Yusuf Y. Deeni ◽

Mark J.I. Paine ◽

Andrew D. Ayrton ◽

Stephen E. Clarke ◽

Richard Chenery ◽

...

Keyword(s):

Cytochrome P450 ◽

Fusion Protein ◽

Biochemical Characterization ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

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Biochemical Characterization of Lauric Acid ω-Hydroxylation by a CYP4A1/NADPH-Cytochrome P450 Reductase Fusion Protein

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.1995.1149 ◽

1995 ◽

Vol 317 (1) ◽

pp. 161-169 ◽

Cited By ~ 18

Author(s):

C.S. Chaurasia ◽

M.A. Alterman ◽

P. Lu ◽

R.P. Hanzlik

Keyword(s):

Cytochrome P450 ◽

Fusion Protein ◽

Lauric Acid ◽

Biochemical Characterization ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/ insect cell system

Xenobiotica ◽

10.1080/00498250110055947 ◽

2001 ◽

Vol 31 (6) ◽

pp. 345-356 ◽

Cited By ~ 22

Author(s):

D. Schwarz ◽

P. Kisselev ◽

H. Honeck ◽

I. Cascorbi ◽

W.-H. Schunck ◽

...

Keyword(s):

Cytochrome P450 ◽

Insect Cell ◽

Cell System ◽

Cytochrome P450 Reductase ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Human Cytochrome ◽

Nadph Cytochrome P450 Reductase

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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The cytochrome P450 2B4-NADPH cytochrome P450 reductase electron transfer complex is not formed by charge-pairing.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)42093-5 ◽

1992 ◽

Vol 267 (21) ◽

pp. 14669-14676

Author(s):

A.I. Voznesensky ◽

J.B. Schenkman

Keyword(s):

Electron Transfer ◽

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Cytochrome P450 2B4 ◽

Nadph Cytochrome P450 Reductase ◽

Electron Transfer Complex

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Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Cytochrome P450 Reductase ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Nadph Cytochrome P450 Reductase

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Organization of NADPH-Cytochrome P450 Reductase and CYP1A2 in the Endoplasmic Reticulum—Microdomain Localization Affects Monooxygenase Function

Molecular Pharmacology ◽

10.1124/mol.110.068817 ◽

2010 ◽

Vol 79 (3) ◽

pp. 549-557 ◽

Cited By ~ 24

Author(s):

Lauren Brignac-Huber ◽

James R. Reed ◽

Wayne L. Backes

Keyword(s):

Endoplasmic Reticulum ◽

Cytochrome P450 ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Nadph Cytochrome P450 Reductase

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