Cyclic Adenosine 3‘:5‘-Monophosphate-Dependent Protein Kinase on the External Surface of LS-174T Human Colon Carcinoma Cells

Biochemistry ◽  
1999 ◽  
Vol 38 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Andrey Kondrashin ◽  
Maria Nesterova ◽  
Yoon S. Cho-Chung
Keyword(s):  
Protein Kinase ◽  
Colon Carcinoma ◽  
External Surface ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Dependent Protein Kinase ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Dependent Protein

Apple Polyphenols Affect Protein Kinase C Activity and the Onset of Apoptosis in Human Colon Carcinoma Cells

2007 ◽  
Vol 55 (13) ◽  
pp. 4999-5006 ◽  
Author(s):  
Melanie Kern ◽  
Gudrun Pahlke ◽  
Kamal Kumar Balavenkatraman ◽  
Frank D. Böhmer ◽  
Doris Marko
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Kinase C ◽  
Human Colon Carcinoma ◽  
Protein Kinase C Activity

scholarly journals Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression To Suppress Colon Carcinoma Cell Invasion

2006 ◽  
Vol 26 (4) ◽  
pp. 1297-1306 ◽  
Author(s):  
Hsin-Sheng Yang ◽  
Connie P. Matthews ◽  
Timothy Clair ◽  
Qing Wang ◽  
Alyson R. Baker ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Colon Carcinoma ◽  
Ectopic Expression ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Mitogen Activated Protein Kinase ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Mitogen Activated Protein ◽  
Protein Kinase Kinase

ABSTRACT Programmed cell death 4 (Pdcd4) suppresses neoplastic transformation by inhibiting the activation of c-Jun and consequently AP-1-dependent transcription. We report that Pdcd4 blocks c-Jun activation by inhibiting the expression of mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)/hematopoietic progenitor kinase 1, a kinase upstream of Jun N-terminal kinase (JNK). cDNA microarray analysis of Pdcd4-overexpressing RKO human colon carcinoma cells revealed MAP4K1 as the sole target of Pdcd4 on the JNK activation pathway. Cotransfection of a MAP4K1 promoter-reporter with Pdcd4 demonstrated inhibition of transcription from the MAP4K1 promoter. Ectopic expression of Pdcd4 in metastatic RKO cells suppressed invasion. MAP4K1 activity is functionally significant in invasion, as overexpression of a dominant negative MAP4K1 (dnMAP4K1) mutant in RKO cells inhibited not only c-Jun activation but also invasion. Overexpression of a MAP4K1 cDNA in Pdcd4-transfected cells rescued the kinase activity of JNK. Thus, Pdcd4 suppresses tumor progression in human colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription.

The influence of extracts from Rubus caesius leaves on human colon carcinoma cells cultured in vitro

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
R Paduch ◽  
M Tomczyk ◽  
A Wiater ◽  
A Dudek ◽  
M Pleszczynska ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Cells Cultured

scholarly journals Fatty acylation of heparan sulfate proteoglycan from human colon carcinoma cells.

1990 ◽  
Vol 265 (32) ◽  
pp. 19980-19989
Author(s):  
R V Iozzo ◽  
I Kovalszky ◽  
N Hacobian ◽  
P K Schick ◽  
J S Ellingson ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Heparan Sulfate Proteoglycan ◽  
Carcinoma Cells ◽  
Sulfate Proteoglycan ◽  
Fatty Acylation ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma
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