Effects of Secondary Structure on DNA and RNA Cleavage by Diplatinum(II)†

Biochemistry ◽  
1998 ◽  
Vol 37 (39) ◽  
pp. 13736-13743 ◽  
Author(s):  
Pamela J. Carter ◽  
Klaus M. Breiner ◽  
H. Holden Thorp
Keyword(s):  
Secondary Structure ◽  
Rna Cleavage ◽  
Dna And Rna

scholarly journals Studies on the interactions of Ag(i) with DNA and their implication on the DNA-templated synthesis of silver nanoclusters and on the interaction with complementary DNA and RNA sequences

RSC Advances ◽  
2021 ◽  
Vol 11 (15) ◽  
pp. 9029-9042
Author(s):  
Alejandra de la Hoz ◽  
Alba Navarro ◽  
Anna Aviñó ◽  
Ramon Eritja ◽  
Raimundo Gargallo
Keyword(s):  
Secondary Structure ◽  
Dna Sequence ◽  
Analytical Signal ◽  
Silver Nanoclusters ◽  
Fluorescent Properties ◽  
Rna Sequences ◽  
Complementary Dna ◽  
Templated Synthesis ◽  
Dna And Rna ◽  
Hybridization Reaction

Variables affecting the fluorescent properties of DNA-stabilized silver nanoclusters are studied. The secondary structure of the AgNC-stabilizing DNA sequence dramatically affects the analytical signal behind the hybridization reaction.

scholarly journals Topoisomerase 3B (TOP3B) DNA and RNA Cleavage Complexes and Pathway to Repair TOP3B-Linked RNA and DNA Breaks

2020 ◽  
Author(s):  
Sourav Saha ◽  
Yilun Sun ◽  
Shar-Yin Huang ◽  
Ukhyun Jo ◽  
Hongliang Zhang ◽  
...  
Keyword(s):  
Rna Cleavage ◽  
Dna Breaks ◽  
Dna And Rna ◽  
Rna And Dna

scholarly journals Mapping in Solution Shows the Peach Latent Mosaic Viroid To Possess a New Pseudoknot in a Complex, Branched Secondary Structure

2000 ◽  
Vol 74 (6) ◽  
pp. 2647-2654 ◽  
Author(s):  
F. Bussière ◽  
J. Ouellet ◽  
F. Côté ◽  
D. Lévesque ◽  
J. P. Perreault
Keyword(s):  
Secondary Structure ◽  
Sequence Comparison ◽  
Unique Feature ◽  
Computer Modelling ◽  
Compact Form ◽  
Dna And Rna ◽  
Chlorotic Mottle ◽  
Nuclease Mapping ◽  
Chrysanthemum Chlorotic Mottle Viroid

ABSTRACT We have investigated the secondary structure of peach latent mosaic viroid (PLMVd) in solution, and we present here the first description of the structure of a branched viroid in solution. Different PLMVd transcripts of plus polarity were produced by using the circularly permuted RNA method and the exploitation of RNA internal secondary structure to position the 5′ and 3′ termini and studied by nuclease mapping and binding shift assays using DNA and RNA oligonucleotides. We show that PLMVd folds into a complex, branched secondary structure. In general, this structure is similar to that reported previously, which was based on sequence comparison and computer modelling. The structural microheterogeneity is apparently limited to only some small domains. More importantly, this structure includes a novel pseudoknot that is conserved in all PLMVd isolates and seems to allow folding into a very compact form. This pseudoknot is also found in chrysanthemum chlorotic mottle viroid, suggesting that it is a unique feature of the viroid members of the PLMVd subgroup.

scholarly journals DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Cell Reports ◽  
2020 ◽  
Vol 33 (13) ◽  
pp. 108569
Author(s):  
Sourav Saha ◽  
Yilun Sun ◽  
Shar-yin Naomi Huang ◽  
Simone Andrea Baechler ◽  
Lorinc Sandor Pongor ◽  
...  
Keyword(s):  
Rna Cleavage ◽  
Repair Pathway ◽  
Dna And Rna ◽  
Protein Crosslinks ◽  
Rna And Dna

scholarly journals Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1340
Author(s):  
Keiko Kawauchi ◽  
Ryoto Urano ◽  
Natsuki Kinoshita ◽  
Shin Kuwamoto ◽  
Takeru Torii ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Secondary Structure ◽  
Molecular Target ◽  
Untranslated Regions ◽  
Reactive Oxidative Species ◽  
Dna And Rna ◽  
Porphyrin Derivatives ◽  
G Quadruplex ◽  
Novel Strategy ◽  
Oxidative Species

G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, such as RAS and MYC. Extensive research has suggested that G4 is a potential molecular target for cancer therapy. Here, we reviewed G4 ligands as photosensitizers for cancer photodynamic therapy (PDT), which is a minimally invasive therapeutic approach. The photosensitizers, such as porphyrins, were found to be highly toxic against cancer cells via the generation of reactive oxidative species (ROS) upon photo-irradiation. Several porphyrin derivatives and analogs, such as phthalocyanines, which can generate ROS upon photo-irradiation, have been reported to act as G4 ligands. Therefore, they have been implicated as promising photosensitizers that can selectively break down cancer-related DNA and RNA forming G4. In this review, we majorly focused on the potential application of G4 ligands as photosensitizers, which would provide a novel strategy for PDT, especially molecularly targeted PDT (mtPDT).

scholarly journals Base and Sugar Requirements for RNA Cleavage of Essential Nucleoside Residues in Internal Loop B of the Hairpin Ribozyme: Implications for Secondary Structure

1996 ◽  
Vol 24 (4) ◽  
pp. 573-581 ◽  
Author(s):  
S. Schmidt ◽  
L. Beigelman ◽  
A. Karpeisky ◽  
N. Usman ◽  
U. S. Sorensen ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Rna Cleavage ◽  
Hairpin Ribozyme ◽  
Internal Loop

scholarly journals Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

Cell ◽  
2015 ◽  
Vol 161 (5) ◽  
pp. 1164-1174 ◽  
Author(s):  
Poulami Samai ◽  
Nora Pyenson ◽  
Wenyan Jiang ◽  
Gregory W. Goldberg ◽  
Asma Hatoum-Aslan ◽  
...  
Keyword(s):  
Rna Cleavage ◽  
Type Iii ◽  
Dna And Rna
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