Functional Comparison of Two Human Monocyte Chemotactic Protein-2 Isoforms, Role of the Amino-Terminal Pyroglutamic Acid and Processing by CD26/Dipeptidyl Peptidase IV†

Biochemistry ◽  
1998 ◽  
Vol 37 (36) ◽  
pp. 12672-12680 ◽  
Author(s):  
Els Van Coillie ◽  
Paul Proost ◽  
Ilse Van Aelst ◽  
Sofie Struyf ◽  
Machteld Polfliet ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Pyroglutamic Acid ◽  
Amino Terminal ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein

Metabolism of glucagon-like peptide-2 in pigs: Role of dipeptidyl peptidase IV

2007 ◽  
Vol 138 (2-3) ◽  
pp. 126-132 ◽  
Author(s):  
Lene Hansen ◽  
Kristine J. Hare ◽  
Bolette Hartmann ◽  
Carolyn F. Deacon ◽  
Randi K. Ugleholdt ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Glucagon Like Peptide

Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV)

FEBS Letters ◽  
2000 ◽  
Vol 466 (1) ◽  
pp. 155-159 ◽  
Author(s):  
S. Wrenger ◽  
T. Kähne ◽  
C. Bohuon ◽  
W. Weglöhner ◽  
S. Ansorge ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Amino Terminal

Critical Role of Dipeptidyl Peptidase IV: A Therapeutic Target for Diabetes and Cancer

2018 ◽  
Vol 19 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Sourav De ◽  
Subhasis Banerjee ◽  
S.K. Ashok Kumar ◽  
Priyankar Paira
Keyword(s):  
Drug Targets ◽  
Critical Role ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Dpp Iv ◽  
Protease Enzyme ◽  
Target Disease ◽  
Dimeric Form ◽  
Epithelium Cells

Diabetes mellitus is an emerging predator and affecting around 422 million adults worldwide. Higher levels of circulating insulin and increased pressure on the pancreas to produce insulin have been inferred as possible etiology for diabetes leading to a higher risk of pancreatic cancer. Out of several drug targets in hypoglycemic discovery, Dipeptidyl peptidase-IV (DPP-IV) has been considered an emerging target. It is a protease enzyme which inactivates incretin hormones i.e., Glucagonlike peptide 1 (GLP-1) and glucose-dependent insulin tropic polypeptide (GIP). Inhibition of DPP-4 results in the longer action of GLP-1 and GIP, therefore, DPP-4 inhibitors play an important role in maintaining glucose homeostasis. In comparison to early oral hypoglycemic, DPP-IV inhibitors are well tolerated and provide a better glycemic control over a longer period. These enzymes are expressed in a dimeric form on the surface of different cells such as prostate, liver and small intestinal epithelium cells. Disruption of the local signaling environment is an emerging factor in cancer development. Till date, not even a single DPP-IV inhibitor as anticancer has been developed. This review focuses on various features of the enzyme and their suitable inhibitors for target disease.

scholarly journals The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation

1998 ◽  
Vol 13 (5) ◽  
pp. 1194-1199 ◽  
Author(s):  
H. B. Zeyneloglu ◽  
L. M. Senturk ◽  
E. Seli ◽  
E. Oral ◽  
D. L. Olive ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein

scholarly journals Endothelin-1 Stimulates Monocytesin vitroto Release Chemotactic Activity Identified as Interleukin-8 and Monocyte Chemotactic Protein-1

1994 ◽  
Vol 3 (2) ◽  
pp. 155-160 ◽  
Author(s):  
E. Helset ◽  
T. Sildnes ◽  
Z. S. Konopski
Keyword(s):  
Human Monocyte ◽  
Chemotactic Activity ◽  
Dependent Manner ◽  
Lipoxygenase Pathway ◽  
Lipoxygenase Inhibitors ◽  
Endothelin 1 ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein ◽  
Stimulation Of

In the present study we examined whether endothelin-1 stimulation of human monocytes causes release of chemotactic factors. It was found that monocytes released neutrophil- and monocyte-chemotactic activity in a dose- and time-dependent manner in response to ET-1. ET-1 did not show any chemotactic activity by itself. NCA was detected in monocyte supernatants in response to ET-1 (0.01–100 nM) after 1, 4, 8 and 24 h stimulation. MCA was detected only after 24 h stimulation with ET-1 (0.1–100 nM). Preincubation of the monocyte cultures with the lipoxygenase inhibitors nordihydroguaiaretic acid (10−4M) or diethylcarbamazine (10−9M) completely abolished the appearance of NCA and MCA. NCA was neutralized by > 75% using a polyclonal antibody against human interleuktn-8. The ET-1 induced release of IL-8 was confirmed by IL-8 ELISA. A monoclonal antibody against human monocyte chemotactic protein-1 neutralized MCA by > 80%. It is concluded that ET-1 stimulation of monocytesin vitrocauses release of neutrophil- and monocyte-chemotactic activity identified as IL-8 and MCP-I respectively. An intact lipoxygenase pathway is crucial for this effect of ET-1 to occur.

scholarly journals Regulation of Chemokine Activity – A Focus on the Role of Dipeptidyl Peptidase IV/CD26

2016 ◽  
Vol 7 ◽  
Author(s):  
Mieke Metzemaekers ◽  
Jo Van Damme ◽  
Anneleen Mortier ◽  
Paul Proost
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv
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