Relationship between Enzyme Specificity and the Backbone Dynamics of Free and Inhibited α-Lytic Protease†,‡

Biochemistry ◽  
1998 ◽  
Vol 37 (21) ◽  
pp. 7696-7707 ◽  
Author(s):  
Jonathan H. Davis ◽  
David A. Agard
Keyword(s):  
Backbone Dynamics ◽  
Enzyme Specificity

Human Neuraminidases Have Reduced Activity Towards Modified Sialic Acids on Glycoproteins

2020 ◽  
Author(s):  
Carmanah D. Hunter ◽  
Elizabeth Porter ◽  
Christopher Cairo
Keyword(s):  
Substrate Specificity ◽  
General Trend ◽  
Sialic Acids ◽  
Enzyme Specificity ◽  
Naturally Occurring ◽  
Bovine Submaxillary Mucin ◽  
Reduced Activity

This work investigated the substrate specificity of hNEU enzymes for a glycoprotein substrate (bovine submaxillary mucin) containing 9-<i>O</i>-acetylated and Neu5Gc residues. Using this model substrate, we observe a general trend for hNEU tolerance of Neu5Ac>Neu5Gc>>>Neu5,9Ac<sub>2</sub>, consistent with our previous results with glycolipid substrates. These results expand our understanding of hNEU enzyme specificity and suggest that naturally occurring modifications of sialic acids can play a role in regulating hNEU activity.

scholarly journals Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix

2014 ◽  
Vol 106 (6) ◽  
pp. 1318-1326 ◽  
Author(s):  
Christina Scharnagl ◽  
Oxana Pester ◽  
Philipp Hornburg ◽  
Daniel Hornburg ◽  
Alexander Götz ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Amyloid Precursor Protein ◽  
Main Chain ◽  
Transmembrane Helix ◽  
Precursor Protein ◽  
Backbone Dynamics ◽  
Side Chain

Backbone dynamics of poly(isopropyl acrylate) in chloroform. A deuterium NMR study

1984 ◽  
Vol 17 (12) ◽  
pp. 2837-2846 ◽  
Author(s):  
Frank D. Blum ◽  
B. Durairaj ◽  
A. S. Padmanabhan
Keyword(s):  
Backbone Dynamics ◽  
Deuterium Nmr ◽  
Nmr Study

Backbone dynamics of the CDK inhibitor p19INK4d studied by 15N NMR relaxation experiments at two field strengths

1998 ◽  
Vol 283 (1) ◽  
pp. 221-229 ◽  
Author(s):  
Christian Renner ◽  
Roland Baumgartner ◽  
Angelika A Noegel ◽  
Tad A Holak
Keyword(s):  
Nmr Relaxation ◽  
Backbone Dynamics ◽  
15N Nmr ◽  
Cdk Inhibitor ◽  
15N Nmr Relaxation ◽  
Relaxation Experiments ◽  
Field Strengths

Reversing enzyme specificity

Nature ◽  
1989 ◽  
Vol 339 (6226) ◽  
pp. 580-581 ◽  
Author(s):  
Thomas L. Poulos
Keyword(s):  
Enzyme Specificity

Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase

2017 ◽  
Vol 1862 (5) ◽  
pp. 441-451 ◽  
Author(s):  
Laura Riccardi ◽  
Jose M. Arencibia ◽  
Luca Bono ◽  
Andrea Armirotti ◽  
Stefania Girotto ◽  
...  
Keyword(s):  
Enzyme Specificity ◽  
Monoacylglycerol Lipase ◽  
Lid Domain
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