Calicheamicin-Mediated DNA Damage in a Reconstituted Nucleosome Is Not Affected by Histone Acetylation:  The Role of Drug Structure in the Target Recognition Process†

Biochemistry ◽  
1997 ◽  
Vol 36 (42) ◽  
pp. 12653-12659 ◽  
Author(s):  
Qi Liang ◽  
Deok-Joon Choi ◽  
Peter C. Dedon
Keyword(s):  
Dna Damage ◽  
Histone Acetylation ◽  
Target Recognition ◽  
Recognition Process

scholarly journals The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis

2006 ◽  
Vol 13 (11) ◽  
pp. 1960-1967 ◽  
Author(s):  
A Rebbaa ◽  
X Zheng ◽  
F Chu ◽  
B L Mirkin
Keyword(s):  
Dna Damage ◽  
Histone Acetylation ◽  
Drug Induced

scholarly journals Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

2020 ◽  
Author(s):  
Yuejing Jiang ◽  
Xiaoji Cong ◽  
Shangwen Jiang ◽  
Ying Dong ◽  
Lei Zhao ◽  
...  
Keyword(s):  
Dna Damage ◽  
Histone Acetylation ◽  
Dna Damage Response ◽  
Regulatory Network ◽  
Exact Role ◽  
Energy Sensor ◽  
Damage Response ◽  
Substrate Network ◽  
Underlying Mechanisms

AbstractAMPK is a conservative energy sensor that plays roles in diverse biologic processes via direct phosphorylation on various substrates. Emerging studies have demonstrated the regulatory roles of AMPK in DNA repair, but the underlying mechanisms remain to be fully understood. Herein, using mass spectrometry-based proteomic technologies, we systematically investigate the regulatory network of AMPK in DNA damage response. Our system-wide phosphoproteome study uncovers a variety of newly-identified potential substrates involved in diverse biologic processes, whereas our system-wide histone modification analysis reveals a linkage between AMPK and histone acetylation. Together with these findings, we discover that AMPK promotes apoptosis by phosphorylating ASPP2 in irradiation-dependent way and regulates histone acetylation by phosphorylating HDAC9 in irradiation-independent way. Besides, we reveal that disturbing the histone acetylation by the bromodomain BRD4 inhibitor JQ-1 enhanced the sensitivity of AMPK-deficient cells to irradiation. Therefore, our studies provided a source to study the phosphorylation and histone acetylation underlying the regulatory network of AMPK, which could be beneficial to understand the exact role of AMPK in DNA damage response.

Role of IFI16 in DNA damage and checkpoint

10.2741/2673 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 236 ◽  
Author(s):  
Mutsuko Ouchi
Keyword(s):  
Dna Damage
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