The Role of Phenylalanine 31 in Maintaining the Conformational Stability of Ribonuclease P2 fromSulfolobus solfataricusunder Extreme Conditions of Temperature and Pressure†

Biochemistry ◽  
1997 ◽  
Vol 36 (29) ◽  
pp. 8733-8742 ◽  
Author(s):  
Enrico Mombelli ◽  
Mohammad Afshar ◽  
Paola Fusi ◽  
Margherita Mariani ◽  
Paolo Tortora ◽  
...  
Keyword(s):  
Conformational Stability ◽  
Extreme Conditions ◽  
Temperature And Pressure

Role of surface residues in conformational stability of human lysozyme

2000 ◽  
Vol 28 (5) ◽  
pp. A410-A410
Author(s):  
J. Funahashi ◽  
K. Takano ◽  
Y. Yamagata ◽  
M. Nakasako ◽  
K. Yutani
Keyword(s):  
Conformational Stability ◽  
Human Lysozyme

The role of logistics in managing the system of medical care organization during a pandemic

2021 ◽  
pp. 16-29
Author(s):  
Natalia Guseva
Keyword(s):  
Interpersonal Relations ◽  
Healthcare Management ◽  
Maximum Efficiency ◽  
Extreme Conditions ◽  
Care Organization ◽  
Organization And Management ◽  
Leading Role ◽  
Current Period ◽  
Close Relationship

In the current period of mass coronavirus infection of the population of Russia, hidden defects in the organization and management of healthcare have been exposed. In this regard, the author proposes to take advantage of the unique concept of logistic management, which has the ability to provide any management system with maximum efficiency. Logistics, as a systemically integrated process of material and information flow management, when used correctly, leads to the satisfaction of consumers’ needs with minimal overall costs. This is especially important for the healthcare system operating in the extreme conditions of the COVID19 pandemic. The article focuses on precisely those logistics theses that should be used in healthcare management in a difficult epidemiological situation. The author draws attention to the priority importance of interpersonal relations in medical teams, the leading role of healthcare organizers in solving problems arising in the management of medical organizations in extreme conditions, as well as the close relationship between the concepts of Logistics and «lean medicine»; which, apparently, will serve as the basis for future reforms in the health care sector

Role of Temperature and Pressure on the Multisensitive Multiferroic Dicyanamide Framework [TPrA][Mn(dca)3] with Perovskite-like Structure

2015 ◽  
Vol 54 (24) ◽  
pp. 11680-11687 ◽  
Author(s):  
Juan M. Bermúdez-García ◽  
Manuel Sánchez-Andújar ◽  
Susana Yáñez-Vilar ◽  
Socorro Castro-García ◽  
Ramón Artiaga ◽  
...  
Keyword(s):  
Temperature And Pressure

scholarly journals The role of an evolutionarily conserved cis-proline in the thioredoxin-like domain of human class Alpha glutathione transferase A1-1

2003 ◽  
Vol 372 (1) ◽  
pp. 241-246 ◽  
Author(s):  
Chris NATHANIEL ◽  
Louise A. WALLACE ◽  
Jonathan BURKE ◽  
Heini W. DIRR
Keyword(s):  
Glutathione Transferase ◽  
Conformational Stability ◽  
Wild Type ◽  
Catalytic Function ◽  
Evolutionarily Conserved ◽  
Glutathione S Transferases ◽  
Equilibrium Unfolding ◽  
The Stability ◽  
Unfolding Kinetics

The thioredoxin-like fold has a βαβαββα topology, and most proteins/domains with this fold have a topologically conserved cis-proline residue at the N-terminus of β-strand 3. This residue plays an important role in the catalytic function and stability of thioredoxin-like proteins, but is reported not to contribute towards the stability of glutathione S-transferases (GSTs) [Allocati, Casalone, Masulli, Caccarelli, Carletti, Parker and Di Ilio (1999) FEBS Lett. 445, 347–350]. In order to further address the role of the cis-proline in the structure, function and stability of GSTs, cis-Pro-56 in human GST (hGST) A1-1 was replaced with a glycine, and the properties of the P56G mutant were compared with those of the wild-type protein. Not only was the catalytic function of the mutant dramatically reduced, so was its conformational stability, as indicated by equilibrium unfolding and unfolding kinetics experiments with urea as denaturant. These findings are discussed in the context of other thioredoxin-like proteins.

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