A Double Mutation at the Tip of the Dimer Interface Loop of Triosephosphate Isomerase Generates Active Monomers with Reduced Stability†

Biochemistry ◽  
1997 ◽  
Vol 36 (32) ◽  
pp. 9655-9662 ◽  
Author(s):  
Wolfgang Schliebs ◽  
Narmada Thanki ◽  
Rainer Jaenicke ◽  
Rik K. Wierenga
Keyword(s):  
Triosephosphate Isomerase ◽  
Double Mutation ◽  
Dimer Interface

Derivatization of the Interface Cysteine of Triosephosphate Isomerase fromTrypanosoma bruceiandTrypanosoma cruzias Probe of the Interrelationship between the Catalytic Sites and the Dimer Interface†

Biochemistry ◽  
1999 ◽  
Vol 38 (13) ◽  
pp. 4114-4120 ◽  
Author(s):  
Ruy Pérez-Montfort ◽  
Georgina Garza-Ramos ◽  
Gloria Hernández Alcántara ◽  
Horacio Reyes-Vivas ◽  
Xiu-gong Gao ◽  
...  
Keyword(s):  
Triosephosphate Isomerase ◽  
Dimer Interface ◽  
Catalytic Sites

Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity

2010 ◽  
Vol 45 (12) ◽  
pp. 5767-5772 ◽  
Author(s):  
Guzmán Álvarez ◽  
Beatriz Aguirre-López ◽  
Javier Varela ◽  
Mauricio Cabrera ◽  
Alicia Merlino ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Triosephosphate Isomerase ◽  
Dimer Interface ◽  
Irreversible Inhibitors

scholarly journals Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase

FEBS Journal ◽  
2009 ◽  
Vol 276 (15) ◽  
pp. 4169-4183 ◽  
Author(s):  
Mousumi Banerjee ◽  
Hemalatha Balaram ◽  
Padmanabhan Balaram
Keyword(s):  
Catalytic Activity ◽  
Triosephosphate Isomerase ◽  
Structural Effects ◽  
Dimer Interface

Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant

1993 ◽  
Vol 211 (3) ◽  
pp. 703-710 ◽  
Author(s):  
Torben V. BORCHERT ◽  
Kathryn PRATT ◽  
Johan Ph. ZEELEN ◽  
Mia CALLENS ◽  
Martin E. M. NOBLE ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Triosephosphate Isomerase ◽  
Dimer Interface

scholarly journals Perturbation of the Dimer Interface of Triosephosphate Isomerase and its Effect on Trypanosoma cruzi

2007 ◽  
Vol 1 (1) ◽  
pp. e1 ◽  
Author(s):  
Vanesa Olivares-Illana ◽  
Adela Rodríguez-Romero ◽  
Ingeborg Becker ◽  
Miriam Berzunza ◽  
Juventino García ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Triosephosphate Isomerase ◽  
Dimer Interface

Hydrophobic Repacking of the Dimer Interface of Triosephosphate Isomerase by in Silico Design and Directed Evolution†‡

Biochemistry ◽  
2008 ◽  
Vol 47 (20) ◽  
pp. 5556-5564 ◽  
Author(s):  
Mariana Peimbert ◽  
Lenin Domínguez-Ramírez ◽  
D. Alejandro Fernández-Velasco
Keyword(s):  
Directed Evolution ◽  
In Silico ◽  
Triosephosphate Isomerase ◽  
Dimer Interface ◽  
In Silico Design

Stability and kinetics of triosephosphate isomerase from Trypanosoma cruzi with an enlarged dimer interface loop

2000 ◽  
Vol 28 (5) ◽  
pp. A318-A318
Author(s):  
N. Cabrera ◽  
G. Garza-Ramos ◽  
A. Gómez-Puyou ◽  
A. RojoDomínguez ◽  
M. Tuena de Gómez-Puyou ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Triosephosphate Isomerase ◽  
Dimer Interface ◽  
Kinetics Of

Catalysis and Stability of Triosephosphate Isomerase fromTrypanosoma bruceiwith Different Residues at Position 14 of the Dimer Interface. Characterization of a Catalytically Competent Monomeric Enzyme†

Biochemistry ◽  
2002 ◽  
Vol 41 (13) ◽  
pp. 4230-4238 ◽  
Author(s):  
Hernández-Alcántara ◽  
Georgina Garza-Ramos ◽  
Guillermo Mendoza Hernández ◽  
Armando Gómez-Puyou ◽  
Ruy Pérez-Montfort
Keyword(s):  
Triosephosphate Isomerase ◽  
Dimer Interface ◽  
Interface Characterization

Inactivation of Triosephosphate Isomerase from Trypanosoma cruzi by an Agent that Perturbs its Dimer Interface

2004 ◽  
Vol 341 (5) ◽  
pp. 1355-1365 ◽  
Author(s):  
Alfredo Téllez-Valencia ◽  
Vanesa Olivares-Illana ◽  
Alejandra Hernández-Santoyo ◽  
Ruy Pérez-Montfort ◽  
Miguel Costas ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Triosephosphate Isomerase ◽  
Dimer Interface
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