Conformations and Orientations of Aromatic Amino Acid Residues of Tachyplesin I in Phospholipid Membranes†

Biochemistry ◽  
1997 ◽  
Vol 36 (14) ◽  
pp. 4352-4359 ◽  
Author(s):  
Osamu Oishi ◽  
Shoji Yamashita ◽  
Etsuko Nishimoto ◽  
Sannamu Lee ◽  
Gohsuke Sugihara ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Phospholipid Membranes ◽  
Amino Acid Residues ◽  
Tachyplesin I

Reductant‐Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins

2019 ◽  
Vol 25 (69) ◽  
pp. 15779-15785 ◽  
Author(s):  
Kheironnesae Rahimidashaghoul ◽  
Iveta Klimánková ◽  
Martin Hubálek ◽  
Michal Korecký ◽  
Matúš Chvojka ◽  
...  
Keyword(s):  
Free Radical ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Nitrogen Heterocycles ◽  
Amino Acid Residues

Fibrous Aggregates of Short Peptides Containing Two Distinct Aromatic Amino Acid Residues

2019 ◽  
Vol 16 (11) ◽  
Author(s):  
Wojciech Lipinski ◽  
Joanna Wasko ◽  
Malgorzata Walczak ◽  
Justyna Fraczyk ◽  
Zbigniew J. Kaminski ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Short Peptides ◽  
Amino Acid Residues

Substitutions of Conserved Aromatic Amino Acid Residues in Subunit I Perturb the Metal Centers of theEscherichia coli bo-Type Ubiquinol Oxidase†

Biochemistry ◽  
1998 ◽  
Vol 37 (6) ◽  
pp. 1632-1639 ◽  
Author(s):  
Tatsushi Mogi ◽  
Jun Minagawa ◽  
Tomoyasu Hirano ◽  
Mariko Sato-Watanabe ◽  
Motonari Tsubaki ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Amino Acid Residues ◽  
Metal Centers ◽  
Ubiquinol Oxidase

scholarly journals Efficient Subgroup C Avian Sarcoma and Leukosis Virus Receptor Activity Requires the IgV Domain of the Tvc Receptor and Proper Display on the Cell Membrane

2008 ◽  
Vol 82 (22) ◽  
pp. 11419-11428 ◽  
Author(s):  
Audelia Munguia ◽  
Mark J. Federspiel
Keyword(s):  
Amino Acid ◽  
Cell Membrane ◽  
Conformational Changes ◽  
Aromatic Amino Acid ◽  
Receptor Activity ◽  
Site Directed Mutagenesis ◽  
Receptor Interaction ◽  
Common Mechanism ◽  
Amino Acid Residues ◽  
Avian Sarcoma

ABSTRACT We recently identified and cloned the receptor for subgroup C avian sarcoma and leukosis viruses [ASLV(C)], i.e., Tvc, a protein most closely related to mammalian butyrophilins, which are members of the immunoglobulin protein family. The extracellular domain of Tvc contains two immunoglobulin-like domains, IgV and IgC, which presumably each contain a disulfide bond important for native function of the protein. In this study, we have begun to identify the functional determinants of Tvc responsible for ASLV(C) receptor activity. We found that the IgV domain of the Tvc receptor is responsible for interacting with the glycoprotein of ASLV(C). Additional experiments demonstrated that a domain was necessary as a spacer between the IgV domain and the membrane-spanning domain for efficient Tvc receptor activity, most likely to orient the IgV domain a proper distance from the cell membrane. The effects on ASLV(C) glycoprotein binding and infection efficiency were also studied by site-directed mutagenesis of the cysteine residues of Tvc as well as conserved amino acid residues of the IgV Tvc domain compared to other IgV domains. In this initial analysis of Tvc determinants important for interacting with ASLV(C) glycoproteins, at least two aromatic amino acid residues in the IgV domain of Tvc, Trp-48 and Tyr-105, were identified as critical for efficient ASLV(C) infection. Interestingly, one or more aromatic amino acid residues have been identified as critical determinants in the other ASLV(A-E) receptors for a proper interaction with ASLV glycoproteins. This suggests that the ASLV glycoproteins may share a common mechanism of receptor interaction with an aromatic residue(s) on the receptor critical for triggering conformational changes in SU that initiate the fusion process required for efficient virus infection.

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