Identification of Elements Critical for Phosphorylation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase by Adenosine Monophosphate-Activated Protein Kinase:  Protein Engineering of the Naturally Nonphosphorylatable 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase fromPseudomonas mevalonii†

Jon A. Friesen; Victor W. Rodwell

doi:10.1021/bi962104l

Identification of Elements Critical for Phosphorylation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase by Adenosine Monophosphate-Activated Protein Kinase: Protein Engineering of the Naturally Nonphosphorylatable 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase fromPseudomonas mevalonii†

Biochemistry ◽

10.1021/bi962104l ◽

1997 ◽

Vol 36 (5) ◽

pp. 1157-1162 ◽

Cited By ~ 7

Author(s):

Jon A. Friesen ◽

Victor W. Rodwell

Keyword(s):

Protein Kinase ◽

Protein Engineering ◽

Coenzyme A ◽

Adenosine Monophosphate ◽

Coenzyme A Reductase

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A novel role for thyroid-stimulating hormone: Up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protei

Hepatology ◽

10.1002/hep.23800 ◽

2010 ◽

Vol 52 (4) ◽

pp. 1401-1409 ◽

Cited By ~ 72

Author(s):

Limin Tian ◽

Yongfeng Song ◽

Mingzhao Xing ◽

Wei Zhang ◽

Guang Ning ◽

...

Keyword(s):

Protein Kinase ◽

Protein Kinase A ◽

Coenzyme A ◽

Cyclic Adenosine Monophosphate ◽

Adenosine Monophosphate ◽

Thyroid Stimulating Hormone ◽

Responsive Element ◽

Kinase A ◽

Stimulating Hormone ◽

Coenzyme A Reductase

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Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

Hepatology Communications ◽

10.1002/hep4.1279 ◽

2018 ◽

Vol 3 (1) ◽

pp. 84-98 ◽

Cited By ~ 15

Author(s):

Kim Loh ◽

Shanna Tam ◽

Lisa Murray-Segal ◽

Kevin Huynh ◽

Peter J. Meikle ◽

...

Keyword(s):

Insulin Resistance ◽

Protein Kinase ◽

Hepatic Steatosis ◽

Coenzyme A ◽

Adenosine Monophosphate ◽

Coenzyme A Reductase

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Stimulatory Effects of Low-Dose 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Fluvatatin on Hepatocyte Growth Factor–Induced Angiogenesis: Involvement of p38 Mitogen-Activated Protein Kinase

Hypertension Research ◽

10.1291/hypres.31.2085 ◽

2008 ◽

Vol 31 (11) ◽

pp. 2085-2096 ◽

Cited By ~ 13

Author(s):

Akira Uruno ◽

Akira Sugawara ◽

Masataka Kudo ◽

Fumitoshi Satoh ◽

Akiko Saito ◽

...

Keyword(s):

Growth Factor ◽

Protein Kinase ◽

Hepatocyte Growth Factor ◽

Reductase Inhibitor ◽

Low Dose ◽

Coenzyme A ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Hepatocyte Growth ◽

Coenzyme A Reductase

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Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.76.9.4375 ◽

1979 ◽

Vol 76 (9) ◽

pp. 4375-4379 ◽

Cited By ~ 49

Author(s):

Z. H. Beg ◽

J. A. Stonik ◽

H. B. Brewer

Keyword(s):

Protein Kinase ◽

Coenzyme A ◽

Enzymic Activity ◽

Kinase A ◽

Coenzyme A Reductase

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Insulin inhibition of 5′ adenosine monophosphate—activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation

Metabolism ◽

10.1016/s0026-0495(97)90229-8 ◽

1997 ◽

Vol 46 (11) ◽

pp. 1270-1274 ◽

Cited By ~ 97

Author(s):

James Gamble ◽

Gary D. Lopaschuk

Keyword(s):

Fatty Acid ◽

Protein Kinase ◽

Fatty Acid Oxidation ◽

Coenzyme A ◽

Adenosine Monophosphate ◽

Acid Oxidation ◽

Acetyl Coenzyme A ◽

Acetyl Coenzyme ◽

Acetyl Coenzyme A Carboxylase ◽

Insulin Inhibition

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Phosphorylation and modulation of the enzymic activity of native and protease-cleaved purified hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by a calcium/calmodulin-dependent protein kinase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)45191-5 ◽

1987 ◽

Vol 262 (27) ◽

pp. 13228-13240 ◽

Cited By ~ 6

Author(s):

Z H Beg ◽

J A Stonik ◽

H B Brewer

Keyword(s):

Protein Kinase ◽

Coenzyme A ◽

Enzymic Activity ◽

Dependent Protein Kinase ◽

Calcium Calmodulin Dependent ◽

Dependent Protein ◽

Coenzyme A Reductase

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Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)89648-x ◽

1985 ◽

Vol 260 (3) ◽

pp. 1682-1687 ◽

Cited By ~ 3

Author(s):

Z H Beg ◽

J A Stonik ◽

H B Brewer

Keyword(s):

Protein Kinase ◽

Coenzyme A ◽

Enzymic Activity ◽

Dependent Protein Kinase ◽

Dependent Protein ◽

Coenzyme A Reductase

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ANTI-APOPTOTIC EFFECT OF ATORVASTATIN, A 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR, ON CARDIAC MYOCYTES THROUGH PROTEIN KINASE C ACTIVATION

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/j.1440-1681.2004.04010.x ◽

2004 ◽

Vol 31 (5-6) ◽

pp. 360-364 ◽

Cited By ~ 21

Author(s):

Koichi Tanaka ◽

Masaaki Honda ◽

Toshikazu Takabatake

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Cardiac Myocytes ◽

Reductase Inhibitor ◽

Coenzyme A ◽

Kinase C ◽

Apoptotic Effect ◽

Protein Kinase C Activation ◽

Coenzyme A Reductase

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Evidence That Barley 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Kinase Is a Member of the Sucrose Nonfermenting-1-Related Protein Kinase Family

PLANT PHYSIOLOGY ◽

10.1104/pp.112.3.1141 ◽

1996 ◽

Vol 112 (3) ◽

pp. 1141-1149 ◽

Cited By ~ 38

Author(s):

JHA. Barker ◽

S. P. Slocombe ◽

K. L. Ball ◽

D. G. Hardie ◽

P. R. Shewry ◽

...

Keyword(s):

Protein Kinase ◽

Coenzyme A ◽

Related Protein ◽

Protein Kinase Family ◽

Kinase Family ◽

Coenzyme A Reductase

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Involvement of de Novo Protein Synthesis, Protein Kinase, Extracellular Ca2+, and Lipoxygenase in Arachidonic Acid Induction of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Genes and Isoprenoid Accumulation in Potato (Solanum tuberosum L.)

PLANT PHYSIOLOGY ◽

10.1104/pp.104.4.1237 ◽

1994 ◽

Vol 104 (4) ◽

pp. 1237-1244 ◽

Cited By ~ 31

Author(s):

D. Choi ◽

R. M. Bostock

Keyword(s):

Protein Synthesis ◽

Arachidonic Acid ◽

Solanum Tuberosum ◽

Protein Kinase ◽

Coenzyme A ◽

De Novo ◽

Solanum Tuberosum L ◽

De Novo Protein Synthesis ◽

Coenzyme A Reductase

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