A Novel Potassium Channel Blocking Toxin from the ScorpionPandinus imperator:  A1H NMR Analysis Using a Nano-NMR Probe†

Biochemistry ◽  
1997 ◽  
Vol 36 (9) ◽  
pp. 2649-2658 ◽  
Author(s):  
M. Delepierre ◽  
A. Prochnicka-Chalufour ◽  
L. D. Possani
Keyword(s):  
Potassium Channel ◽  
Nmr Analysis ◽  
Channel Blocking

A novel potassium channel-blocking toxin from the scorpion Pandinus imperator: a1H-NMR analysis using a nano-NMR probe

Toxicon ◽  
1997 ◽  
Vol 35 (12) ◽  
pp. 1663
Author(s):  
M. Delepierre ◽  
A. Prochnicka-Chalufour ◽  
L. Possani
Keyword(s):  
Potassium Channel ◽  
Nmr Analysis ◽  
Channel Blocking

scholarly journals Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Johara Boldrini-França ◽  
Ernesto Lopes Pinheiro-Junior ◽  
Steve Peigneur ◽  
Manuela Berto Pucca ◽  
Felipe Augusto Cerni ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Serine Protease ◽  
Snake Venom ◽  
Antitumor Activities ◽  
Channel Blocking ◽  
Potential Antitumor

Two Mutations of synaptic transmission in Drosophila

1977 ◽  
Vol 198 (1130) ◽  
pp. 87-108 ◽  
Keyword(s):  
Synaptic Transmission ◽  
Potassium Channel ◽  
Nerve Terminal ◽  
Neuromuscular Junctions ◽  
Nerve Impulse ◽  
Blocking Agent ◽  
The Other ◽  
Channel Blocking ◽  
Single Nerve ◽  
Evoked Transmitter Release

Evoked transmitter release is abnormal at the larval neuromuscular junctions of two Drosophila mutants. Following a single nerve impulse, the increased calcium conductance at the nerve terminal, which lasts for 1 ms in normal larvae, lasts for at least 60 ms in one mutant and several seconds in the other. Both mutations appear to affect the same gene on the X-chromosome. Normal larvae treated with 4-aminopyridine, a potassium channel blocking agent, mimic the abnormal synaptic transmission of one mutant. Normal larvae treated with tetraethylammonium, another potassium channel blocking agent, mimic the abnormal synaptic transmission of the other mutant. From these and other experiments, we suggest that the abnormal neuromuscular transmission in these mutants may be caused by defective potassium channels in the nerve terminal membrane.

Plasmodium falciparum: Growth response to potassium channel blocking compounds

2008 ◽  
Vol 120 (3) ◽  
pp. 280-285 ◽  
Author(s):  
Karena L. Waller ◽  
Kami Kim ◽  
Thomas V. McDonald
Keyword(s):  
Plasmodium Falciparum ◽  
Potassium Channel ◽  
Growth Response ◽  
Channel Blocking

Regenerating mammalian nerve fibres: changes in action potential waveform and firing characteristics following blockage of potassium conductance

1982 ◽  
Vol 217 (1206) ◽  
pp. 77-87 ◽  
Keyword(s):  
Action Potential ◽  
Potassium Channel ◽  
Potassium Conductance ◽  
Compound Action Potential ◽  
Blocking Agent ◽  
Nerve Fibres ◽  
Channel Blocking ◽  
Action Potential Waveform ◽  
Myelinated Fibres ◽  
Firing Properties

Extracellular application of potassium channel blocking agents is known to increase the amplitude and duration of the compound action potential in non-myelinated and demyelinated axons, but not in mature mammalian myelinated fibres. In the present study we used intra-axonal and whole nerve recording techniques to study the effects of the potassium channel blocking agent 4-aminopyridine (4-AP) on regenerating rat nerve fibres. Our results indicate that early regenerating (premyelinated) axons show considerable broadening of the action potential after 4-AP application and late regenerating (myelinated) axons give rise to burst activity following a single stimulus after 4-AP application. 4-AP did not affect spike waveform or firing properties of normal mature sciatic nerve fibres. These results demonstrate the importance of potassium conductance in stabilizing firing properties of myelinated regenerating axons.

Long-term regenerated nerve fibres retain sensitivity to potassium channel blocking agents

Nature ◽  
1983 ◽  
Vol 304 (5927) ◽  
pp. 640-642 ◽  
Author(s):  
Jeffery D. Kocsis ◽  
Stephen G. Waxman
Keyword(s):  
Potassium Channel ◽  
Nerve Fibres ◽  
Blocking Agents ◽  
Channel Blocking
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