Ionization Equilibria for Side-Chain Carboxyl Groups in Oxidized and Reduced Human Thioredoxin and in the Complex with Its Target Peptide from the Transcription Factor NFκB†

Biochemistry ◽  
1996 ◽  
Vol 35 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Jun Qin ◽  
G. Marius Clore ◽  
Angela M. Gronenborn
Keyword(s):  
Transcription Factor ◽  
Side Chain ◽  
Carboxyl Groups ◽  
Target Peptide ◽  
Ionization Equilibria ◽  
Transcription Factor Nfκb

scholarly journals Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NFκB

Structure ◽  
1995 ◽  
Vol 3 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Jun Qin ◽  
G.Marius Clore ◽  
WM Poindexter Kennedy ◽  
Jeffrey R Huth ◽  
Angela M Gronenborn
Keyword(s):  
Transcription Factor ◽  
Solution Structure ◽  
Intermediate Complex ◽  
Target Peptide ◽  
Mixed Disulfide ◽  
Transcription Factor Nfκb

scholarly journals Bcl-2 Activates the Transcription Factor NFκB through the Degradation of the Cytoplasmic Inhibitor IκBα

1998 ◽  
Vol 273 (37) ◽  
pp. 23946-23951 ◽  
Author(s):  
Danielle de Moissac ◽  
Shareef Mustapha ◽  
Arnold H. Greenberg ◽  
Lorrie A. Kirshenbaum
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Nfκb

scholarly journals Transcription Factor NFκB Expression and Postsurgical Organ Dysfunction

2001 ◽  
Vol 233 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Sharmila Foulds ◽  
Christine Galustian ◽  
Averil O. Mansfield ◽  
Michael Schachter
Keyword(s):  
Transcription Factor ◽  
Organ Dysfunction ◽  
Transcription Factor Nfκb

A role for PKC-δ and PI 3-kinase in TNF-α-mediated antiapoptotic signaling in the human neutrophil

2002 ◽  
Vol 283 (1) ◽  
pp. C48-C57 ◽  
Author(s):  
Laurie E. Kilpatrick ◽  
Julia Y. Lee ◽  
Kathleen M. Haines ◽  
Donald E. Campbell ◽  
Kathleen E. Sullivan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Synthesis ◽  
Proinflammatory Cytokine ◽  
Tumor Necrosis ◽  
Spontaneous Apoptosis ◽  
Kinase C ◽  
Tnf Α ◽  
Cytokine Tumor Necrosis Factor ◽  
Transcription Factor Nfκb ◽  
Necrosis Factor

The proinflammatory cytokine tumor necrosis factor (TNF)-α has been implicated in the attenuation of neutrophil spontaneous apoptosis during sepsis. Antiapoptotic signaling is principally mediated through the p60TNF receptor (p60TNFR). In neutrophils, TNF-α is an incomplete secretagogue and requires input from a ligated integrin(s) for neutrophil activation. In adherent neutrophils, TNF-α triggers association of both protein kinase C (PKC)-δ and phosphatidylinositol (PI) 3-kinase with the p60TNFR. In this study, a role for PKC-δ and PI 3-kinase in TNF-α-mediated antiapoptotic signaling was examined. TNF-α inhibited spontaneous apoptosis in fibronectin-adherent neutrophils, and this antiapoptotic signaling was blocked by the PKC-δ inhibitor rottlerin, but not by an inhibitor of Ca2+-dependent PKC isotypes, Go-6976. Inhibition of PI 3-kinase by LY-294002 also inhibited TNF-α-mediated antiapoptotic signaling. Cycloheximide blocked TNF-α-mediated antiapoptotic signaling, suggesting protein synthesis is required. Inhibition of either PKC-δ or PI 3-kinase attenuated TNF-α-mediated activation of the antiapoptotic transcription factor NFκB. Thus both PKC-δ and PI 3-kinase have essential roles in TNF-α-mediated antiapoptotic signaling in adherent neutrophils.

scholarly journals Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Albert Escobedo ◽  
Busra Topal ◽  
Micha B. A. Kunze ◽  
Juan Aranda ◽  
Giulio Chiesa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hydrogen Bonds ◽  
Main Chain ◽  
Side Chain
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