Ubiquitination-Dependent Proteolysis ofO6-Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation withO6-Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea†

Biochemistry ◽  
1996 ◽  
Vol 35 (4) ◽  
pp. 1328-1334 ◽  
Author(s):  
Kalkunte S. Srivenugopal ◽  
Xiao-Hua Yuan ◽  
Henry S. Friedman ◽  
Francis Ali-Osman
Keyword(s):  
Tumor Cells ◽  
Dna Methyltransferase ◽  
Methylguanine Dna Methyltransferase ◽  
Murine Tumor ◽  
Murine Tumor Cells

scholarly journals Molecular and Circulating Biomarkers of Brain Tumors

2021 ◽  
Vol 22 (13) ◽  
pp. 7039
Author(s):  
Wojciech Jelski ◽  
Barbara Mroczko
Keyword(s):  
Brain Tumors ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Extracellular Vesicles ◽  
Dna Methyltransferase ◽  
Growth Factor Receptor ◽  
Response To Treatment ◽  
Liquid Biopsies ◽  
Methylguanine Dna Methyltransferase ◽  
The Central Nervous System

Brain tumors are the most common malignant primary intracranial tumors of the central nervous system. They are often recognized too late for successful therapy. Minimally invasive methods are needed to establish a diagnosis or monitor the response to treatment of CNS tumors. Brain tumors release molecular information into the circulation. Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a substitute for tumor tissue. Tumor-derived biomarkers include nucleic acids, proteins, and tumor-derived extracellular vesicles that accumulate in blood or cerebrospinal fluid. In recent years, circulating tumor cells have also been identified in the blood of glioblastoma patients. In this review of the literature, the authors highlight the significance, regulation, and prevalence of molecular biomarkers such as O6-methylguanine-DNA methyltransferase, epidermal growth factor receptor, and isocitrate dehydrogenase. Herein, we critically review the available literature on plasma circulating tumor cells (CTCs), cell-free tumors (ctDNAs), circulating cell-free microRNAs (cfmiRNAs), and circulating extracellular vesicles (EVs) for the diagnosis and monitoring of brain tumor. Currently available markers have significant limitations.While much research has been conductedon these markers, there is still a significant amount that we do not yet understand, which may account for some conflicting reports in the literature.

Expression of Ly-6, a marker for highly malignant murine tumor cells, is regulated by growth conditions and stress

1998 ◽  
Vol 77 (2) ◽  
pp. 306-313 ◽  
Author(s):  
Alexandra Treister ◽  
Orit Sagi-Assif ◽  
Michal Meer ◽  
Nechama I. Smorodinsky ◽  
Romema Anavi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Growth Conditions ◽  
Murine Tumor ◽  
Murine Tumor Cells

Echinococcus multilocularis: In vitro secretion of antigen by hybridomas from metacestode germinal cells and murine tumor cells

1989 ◽  
Vol 68 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Angela Dieckmann-Schuppert ◽  
Andreas Ruppel ◽  
Reinhard Burger ◽  
Werner Frank
Keyword(s):  
Tumor Cells ◽  
Echinococcus Multilocularis ◽  
Murine Tumor ◽  
Germinal Cells ◽  
Murine Tumor Cells

scholarly journals Identification of the alpha IIb beta 3 integrin in murine tumor cells.

1992 ◽  
Vol 267 (24) ◽  
pp. 17314-17320
Author(s):  
Y.Q. Chen ◽  
X Gao ◽  
J Timar ◽  
D Tang ◽  
I.M. Grossi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Murine Tumor ◽  
Murine Tumor Cells

scholarly journals Agglutination of murine tumor cells by sera from various cancer patients

Cancer ◽  
1977 ◽  
Vol 40 (2) ◽  
pp. 693-699
Author(s):  
Takashi Umeda ◽  
Takae Tanino ◽  
Michiko Saito ◽  
Kohji Egawa
Keyword(s):  
Cancer Patients ◽  
Tumor Cells ◽  
Murine Tumor ◽  
Murine Tumor Cells

scholarly journals Cytolytic Heterogeneity of Polymorphonuclear Leukocytes in Killing of Murine Tumor Cells

1988 ◽  
Vol 79 (11) ◽  
pp. 1217-1223 ◽  
Author(s):  
Masatoshi Yamazaki ◽  
Michihiro Ikenami ◽  
Takashi Sugiyama
Keyword(s):  
Tumor Cells ◽  
Polymorphonuclear Leukocytes ◽  
Murine Tumor ◽  
Murine Tumor Cells
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