HIV-1 Peptide Vaccine Candidates: Selecting Constrained V3 Peptides with Highest Affinity to Antibody 447-52D

Biochemistry ◽  
2009 ◽  
Vol 48 (33) ◽  
pp. 7867-7877 ◽  
Author(s):  
Brenda Mester ◽  
Revital Manor ◽  
Amit Mor ◽  
Boris Arshava ◽  
Osnat Rosen ◽  
...  
Keyword(s):  
Peptide Vaccine ◽  
Vaccine Candidates ◽  
Hiv 1

Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients

2004 ◽  
Author(s):  
Hiroko Takedatsu ◽  
Shigeki Shichijo ◽  
Kouichi Azuma ◽  
Hidetoshi Takedatsu ◽  
Michio Sata ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Peptide Vaccine ◽  
Epithelial Cancer ◽  
Vaccine Candidates

Predicting peptide vaccine candidates against H1N1 influenza virus through theoretical approaches

2015 ◽  
Vol 62 (1) ◽  
pp. 3-15 ◽  
Author(s):  
Martiniano Bello ◽  
Rafael Campos-Rodriguez ◽  
Saul Rojas-Hernandez ◽  
Arturo Contis-Montes de Oca ◽  
José Correa-Basurto
Keyword(s):  
Influenza Virus ◽  
Peptide Vaccine ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Vaccine Candidates ◽  
Theoretical Approaches

scholarly journals Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives

2014 ◽  
Vol 2014 ◽  
pp. 1-24 ◽  
Author(s):  
P. J. Klasse
Keyword(s):  
Cellular Immunity ◽  
Neutralizing Antibodies ◽  
Viral Infections ◽  
Viral Proteins ◽  
Virus Neutralization ◽  
Virus Infectivity ◽  
Viral Pathogens ◽  
Enveloped Viruses ◽  
Vaccine Candidates ◽  
Hiv 1

Neutralizing antibodies (NAbs) can be both sufficient and necessary for protection against viral infections, although they sometimes act in concert with cellular immunity. Successful vaccines against viruses induce NAbs but vaccine candidates against some major viral pathogens, including HIV-1, have failed to induce potent and effective such responses. Theories of how antibodies neutralize virus infectivity have been formulated and experimentally tested since the 1930s; and controversies about the mechanistic and quantitative bases for neutralization have continually arisen. Soluble versions of native oligomeric viral proteins that mimic the functional targets of neutralizing antibodies now allow the measurement of the relevant affinities of NAbs. Thereby the neutralizing occupancies on virions can be estimated and related to the potency of the NAbs. Furthermore, the kinetics and stoichiometry of NAb binding can be compared with neutralizing efficacy. Recently, the fundamental discovery that the intracellular factor TRIM21 determines the degree of neutralization of adenovirus has provided new mechanistic and quantitative insights. Since TRIM21 resides in the cytoplasm, it would not affect the neutralization of enveloped viruses, but its range of activity against naked viruses will be important to uncover. These developments bring together the old problems of virus neutralization—mechanism, stoichiometry, kinetics, and efficacy—from surprising new angles.

Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa

Vaccine ◽  
2008 ◽  
Vol 26 (22) ◽  
pp. 2788-2795 ◽  
Author(s):  
Walter Jaoko ◽  
Frederick N. Nakwagala ◽  
Omu Anzala ◽  
Gloria Omosa Manyonyi ◽  
Josephine Birungi ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
East Africa ◽  
Vaccine Candidates ◽  
Modified Vaccinia Virus Ankara ◽  
Hiv 1 ◽  
Low Dosage

scholarly journals Optimization of HIV-1 Envelope DNA Vaccine Candidates within Three Different Animal Models, Guinea Pigs, Rabbits and Cynomolgus Macaques

Vaccines ◽  
2013 ◽  
Vol 1 (3) ◽  
pp. 305-327 ◽  
Author(s):  
Marie Borggren ◽  
Lasse Vinner ◽  
Betina Andresen ◽  
Berit Grevstad ◽  
Johanna Repits ◽  
...  
Keyword(s):  
Animal Models ◽  
Dna Vaccine ◽  
Guinea Pigs ◽  
Vaccine Candidates ◽  
Cynomolgus Macaques ◽  
Hiv 1
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