scholarly journals Role of the 2-Amino Group of Purines during dNTP Polymerization by Human DNA Polymerase α†

Biochemistry ◽  
2009 ◽  
Vol 48 (1) ◽  
pp. 180-189 ◽  
Author(s):  
Jennifer N. Patro ◽  
Milan Urban ◽  
Robert D. Kuchta
Keyword(s):  
Dna Polymerase ◽  
Amino Group ◽  
Dna Polymerase Α ◽  
Human Dna

scholarly journals Mutational Studies of Human DNA Polymerase α

1995 ◽  
Vol 270 (37) ◽  
pp. 21563-21570 ◽  
Author(s):  
Qun Dong ◽  
Teresa S.-F. Wang
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α ◽  
Human Dna

Role of DNA polymerase α and δ in radiation clastogenesis

1991 ◽  
Vol 262 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Michael A. Bender ◽  
Ruth C. Moore ◽  
Beatrice E. Pyatt
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α

scholarly journals Human DNA polymerase α interacts with mismatch repair proteins MSH2 and MSH6

FEBS Letters ◽  
2016 ◽  
Vol 590 (23) ◽  
pp. 4233-4241 ◽  
Author(s):  
Harri M. Itkonen ◽  
Jukka Kantelinen ◽  
Markku Vaara ◽  
Sinikka Parkkinen ◽  
Bernhard Schlott ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Polymerase ◽  
Dna Polymerase Α ◽  
Human Dna ◽  
Mismatch Repair Proteins

Regulation of the synthesis of DNA polymerase-α in regenerating liver by calcium and 1,25-dihydroxyvitamin D3

1989 ◽  
Vol 67 (7) ◽  
pp. 345-351 ◽  
Author(s):  
Marianna Sikorska ◽  
Ian de Belle ◽  
James F. Whitfield ◽  
P. Roy Walker
Keyword(s):  
Dna Polymerase ◽  
Calcium Ions ◽  
Nuclear Matrix ◽  
Critical Stage ◽  
Dihydroxyvitamin D3 ◽  
Dna Polymerase Α ◽  
Enzyme Molecules ◽  
Rat Livers ◽  
Α Activity

Digestion of nuclei from normal or partially hepatectomised rat livers with endogenous nucleases liberated a pool of cryptic DNA polymerase-α activity which had previously gone unrecognised. Most of this activity is released into the supernatant as free enzyme molecules (11S), but a small fraction of it is released as a complex of 16S (probably with DNA primase). About 40% of the enzyme remains in the pellet, which contains undigested chromatin and components of the residual nuclear matrix and nucleoskeletal structures. Virtually all of this remaining activity is extracted by 2.0 M salt. The activity of DNA polymerase-α increases equally in all nuclear fractions during the period of DNA replication in regenerating rat liver. Lowering of the serum calcium level by thyroparathyroidectomy does not affect basal DNA polymerase-α activity, but prevents induction of the enzyme during the later stages of prereplicative development. However, an injection of 1α,25-dihydroxy vitamin D3 into the rat during the first 6 h after partial hepatectomy restores the ability of the hepatocytes to induce DNA polymerase-α activity and initiate DNA synthesis. These results are discussed in terms of the role of calcium ions in the regulation of the critical stage of prereplicative development which commits the cells to DNA replication.Key words: replication, nuclear, matrix, complex, lamina, reductase.

scholarly journals Human DNA polymerase α in binary complex with a DNA:DNA template-primer

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Javier Coloma ◽  
Robert E. Johnson ◽  
Louise Prakash ◽  
Satya Prakash ◽  
Aneel K. Aggarwal
Keyword(s):  
Dna Polymerase ◽  
Binary Complex ◽  
Dna Polymerase Α ◽  
Human Dna

scholarly journals The algorithm of estimation of the K m values for primers in DNA synthesis catalyzed by human DNA polymerase α

FEBS Letters ◽  
1996 ◽  
Vol 399 (1-2) ◽  
pp. 113-116 ◽  
Author(s):  
Tat'yana I. Kolocheva ◽  
Galiya A. Maksakova ◽  
Ol'ga D. Zakharova ◽  
Georgy A. Nevinsky
Keyword(s):  
Dna Synthesis ◽  
Dna Polymerase ◽  
Dna Polymerase Α ◽  
Human Dna
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