Cross-Strand Pairing and Amyloid Assembly

Biochemistry ◽  
2008 ◽  
Vol 47 (38) ◽  
pp. 10018-10026 ◽  
Author(s):  
Yan Liang ◽  
Sai Venkatesh Pingali ◽  
Ashutosh S. Jogalekar ◽  
James P. Snyder ◽  
Pappannan Thiyagarajan ◽  
...  
Keyword(s):  
Amyloid Assembly

Targeting Insulin Amyloid Assembly by Aminosugars and Their Derivatives

2011 ◽  
Vol 18 (6) ◽  
pp. 588-593 ◽  
Author(s):  
V. Nagaveni ◽  
M. Sravani ◽  
S. Prabhakar ◽  
B. Sreedhar ◽  
M. Vairamani
Keyword(s):  
Amyloid Assembly

scholarly journals Kinetic Intermediates in Amyloid Assembly

2014 ◽  
Vol 136 (43) ◽  
pp. 15146-15149 ◽  
Author(s):  
Chen Liang ◽  
Rong Ni ◽  
Jillian E. Smith ◽  
W. Seth Childers ◽  
Anil K. Mehta ◽  
...  
Keyword(s):  
Amyloid Assembly ◽  
Kinetic Intermediates

scholarly journals Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus

ACS Omega ◽  
2021 ◽  
Author(s):  
Zahra Najarzadeh ◽  
Janni Nielsen ◽  
Azad Farzadfard ◽  
Vita Sereikaite ◽  
Kristian Strømgaard ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Human Fibrinogen ◽  
Amyloid Assembly

scholarly journals Amyloid by Design: Intrinsic Regulation of Microbial Amyloid Assembly

2018 ◽  
Vol 430 (20) ◽  
pp. 3631-3641 ◽  
Author(s):  
Maya Deshmukh ◽  
Margery L. Evans ◽  
Matthew R. Chapman
Keyword(s):  
Intrinsic Regulation ◽  
Amyloid Assembly

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

2021 ◽  
Author(s):  
Katerina Konstantoulea ◽  
Patricia Guerreiro ◽  
Meine Ramakers ◽  
Nikolaos Louros ◽  
Liam D Aubrey ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Amyloid Assembly

Peptide‐Based Inhibitors of Amyloid Assembly

2006 ◽  
pp. 273-312 ◽  
Author(s):  
Kimberly L. Sciarretta ◽  
David J. Gordon ◽  
Stephen C. Meredith
Keyword(s):  
Amyloid Assembly

scholarly journals Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

2020 ◽  
Vol 295 (21) ◽  
pp. 7544-7553 ◽  
Author(s):  
Dexter N. Dean ◽  
Jennifer C. Lee
Keyword(s):  
Alternative Splicing ◽  
Amyloid Fibrils ◽  
Limited Proteolysis ◽  
Amyloid Formation ◽  
Functional Amyloid ◽  
Melanin Biosynthesis ◽  
Functional Amyloids ◽  
Fibril Morphology ◽  
Amyloid Assembly ◽  
Β Sheet

The premelanosomal protein (PMEL17) forms functional amyloid fibrils involved in melanin biosynthesis. Multiple PMEL17 isoforms are produced, two of which arise from excision of a cryptic intron within the amyloid-forming repeat (RPT) domain, leading to long (lRPT) and short (sRPT) isoforms with 10 and 7 imperfect repeats, respectively. Both lRPT and sRPT isoforms undergo similar pH-dependent mechanisms of amyloid formation and fibril dissolution. Here, using human PMEL17, we tested the hypothesis that the minor, but more aggregation-prone, sRPT facilitates amyloid formation of lRPT. We observed that cross-seeding by sRPT fibrils accelerates the rate of lRPT aggregation, resulting in propagation of an sRPT-like twisted fibril morphology, unlike the rodlike structure that lRPT normally adopts. This templating was specific, as the reversed reaction inhibited sRPT fibril formation. Despite displaying ultrastructural differences, self- and cross-seeded lRPT fibrils had a similar β-sheet structured core, revealed by Raman spectroscopy, limited-proteolysis, and fibril disaggregation experiments, suggesting the fibril twist is modulated by N-terminal residues outside the amyloid core. Interestingly, bioinformatics analysis of PMEL17 homologs from other mammals uncovered that long and short RPT isoforms are conserved among members of this phylogenetic group. Collectively, our results indicate that the short isoform of RPT serves as a “nucleator” of PMEL17 functional amyloid formation, mirroring how bacterial functional amyloids assemble during biofilm formation. Whereas bacteria regulate amyloid assembly by using individual genes within the same operon, we propose that the modulation of functional amyloid formation in higher organisms can be accomplished through alternative splicing.

MoO3−x nanodots with dual enzyme mimic activities as multifunctional modulators for amyloid assembly and neurotoxicity

2019 ◽  
Vol 539 ◽  
pp. 575-584 ◽  
Author(s):  
Qiusen Han ◽  
Xinhuan Wang ◽  
Xueliang Liu ◽  
Yufei Zhang ◽  
Shuangfei Cai ◽  
...  
Keyword(s):  
Enzyme Mimic ◽  
Amyloid Assembly

scholarly journals Understanding the complex mechanisms of β2-microglobulin amyloid assembly

FEBS Journal ◽  
2011 ◽  
Vol 278 (20) ◽  
pp. 3868-3883 ◽  
Author(s):  
Timo Eichner ◽  
Sheena E. Radford
Keyword(s):  
Β2 Microglobulin ◽  
Complex Mechanisms ◽  
Amyloid Assembly
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