Dynamical Characterization of the Heme NO Oxygen Binding (HNOX) Domain. Insight into Soluble Guanylate Cyclase Allosteric Transition†

Biochemistry ◽  
2008 ◽  
Vol 47 (36) ◽  
pp. 9416-9427 ◽  
Author(s):  
Luciana Capece ◽  
Dario A. Estrin ◽  
Marcelo A. Marti
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Oxygen Binding ◽  
Allosteric Transition ◽  
Insight Into

Characterization of a Carbon Monoxide-Activated Soluble Guanylate Cyclase fromChlamydomonas reinhardtii

Biochemistry ◽  
2019 ◽  
Vol 58 (17) ◽  
pp. 2250-2259 ◽  
Author(s):  
Benjamin G. Horst ◽  
Edna M. Stewart ◽  
Aren A. Nazarian ◽  
Michael A. Marletta
Keyword(s):  
Carbon Monoxide ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase

Structural characterization of nitric oxide-bound soluble Guanylate Cyclase using resonance Raman spectroscopy

2013 ◽  
Vol 17 (03) ◽  
pp. 240-246
Author(s):  
Biswajit Pal ◽  
Katsuhiro Tanaka ◽  
Shigeo Takenaka ◽  
Tajith B. Shaik ◽  
Teizo Kitagawa
Keyword(s):  
Nitric Oxide ◽  
Raman Spectroscopy ◽  
Guanylate Cyclase ◽  
Protein Interactions ◽  
Bound States ◽  
Soluble Guanylate Cyclase ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Bending Modes

Mammalian soluble Guanylate Cyclase (sGC), working as a physiological NO receptor, is investigated using resonance Raman spectroscopy for NO bound states with different saturation levels in the presence and absence of effectors. The Fe–NO (νFe–NO) and N–O (νN-O) stretching bands appeared at 521 and 1681 cm-1, respectively, without effectors, but νN-O was split into 1681 and 1699 cm-1 in the presence of GTP and shifted to 1687 cm-1 in the presence of YC-1 or BAY 41-2272, while νFe-NO remained unaltered. The split two νN-O bands were independent of NO saturation levels. GTP or YC-1/BAY 41-2272 altered the vinyl and propionate bending modes from 423 to 399 cm-1 and 376 to 367 cm-1, respectively. Based on these observations, allosteric effects on NO …protein interactions are discussed.

scholarly journals Characterization of Two Different Five-Coordinate Soluble Guanylate Cyclase Ferrous–Nitrosyl Complexes†

Biochemistry ◽  
2008 ◽  
Vol 47 (12) ◽  
pp. 3892-3899 ◽  
Author(s):  
Emily R. Derbyshire ◽  
Alexander Gunn ◽  
Mohammed Ibrahim ◽  
Thomas G. Spiro ◽  
R. David Britt ◽  
...  
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Nitrosyl Complexes

scholarly journals Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat

ChemBioChem ◽  
2012 ◽  
Vol 13 (7) ◽  
pp. 977-981 ◽  
Author(s):  
Nur Basak Surmeli ◽  
Michael A. Marletta
Keyword(s):  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Insight Into

Generation and Characterization of a Stable Soluble Guanylate Cyclase-Overexpressing CHO Cell Line

Nitric Oxide ◽  
1999 ◽  
Vol 3 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Eva Maria Becker ◽  
Frank Wunder ◽  
Raimund Kast ◽  
Chantal Robyr ◽  
Markus Hoenicka ◽  
...  
Keyword(s):  
Cell Line ◽  
Guanylate Cyclase ◽  
Soluble Guanylate Cyclase ◽  
Cho Cell ◽  
Cho Cell Line
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