The Regulatory β Subunit of Protein Kinase CK2 Contributes to the Recognition of the Substrate Consensus Sequence. A Study with an eIF2β-Derived Peptide†

Biochemistry ◽  
2008 ◽  
Vol 47 (32) ◽  
pp. 8317-8325 ◽  
Author(s):  
Giorgia Poletto ◽  
Jordi Vilardell ◽  
Oriano Marin ◽  
Mario A. Pagano ◽  
Giorgio Cozza ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Consensus Sequence ◽  
Β Subunit ◽  
Substrate Consensus Sequence ◽  
Kinase Ck2

The crystal structure of the complex of Zea maysα subunit with a fragment of human β subunit provides the clue to the architecture of protein kinase CK2 holoenzyme

2000 ◽  
Vol 267 (16) ◽  
pp. 5184-5190 ◽  
Author(s):  
Roberto Battistutta ◽  
Stefania Sarno ◽  
Erika De Moliner ◽  
Oriano Marin ◽  
Olaf-G. Issinger ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Β Subunit ◽  
Kinase Ck2

scholarly journals The regulatory β-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis

Oncogene ◽  
2008 ◽  
Vol 27 (37) ◽  
pp. 4986-4997 ◽  
Author(s):  
C W Yde ◽  
B B Olsen ◽  
D Meek ◽  
N Watanabe ◽  
B Guerra
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Cell Cycle Progression ◽  
Β Subunit ◽  
Cycle Progression ◽  
Kinase Ck2

Overexpression of Nuclear Protein Kinase CK2 β Subunit and Prognosis in Human Gastric Carcinoma

2010 ◽  
Vol 17 (6) ◽  
pp. 1695-1702 ◽  
Author(s):  
Kai-Yuan Lin ◽  
Chia-Lang Fang ◽  
Yi Chen ◽  
Chien-Feng Li ◽  
Sheng-Hsuan Chen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Gastric Carcinoma ◽  
Protein Kinase Ck2 ◽  
Nuclear Protein ◽  
Β Subunit ◽  
Human Gastric Carcinoma ◽  
Kinase Ck2

scholarly journals Site-directed mutants of the β subunit of protein kinase CK2 demonstrate the important role of Pro-58

FEBS Letters ◽  
1995 ◽  
Vol 368 (2) ◽  
pp. 211-214 ◽  
Author(s):  
María Victoria Hinrichs ◽  
Marta Gatica ◽  
Catherine C. Allende ◽  
Jorge E. Allende
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Β Subunit ◽  
Kinase Ck2

scholarly journals Biochemical evidence that the N-terminal segments of the α subunit and the β subunit play interchangeable roles in the activation of protein kinase CK2

FEBS Letters ◽  
1998 ◽  
Vol 441 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Stefania Sarno ◽  
Oriano Marin ◽  
Paola Ghisellini ◽  
Flavio Meggio ◽  
Lorenzo A Pinna
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Β Subunit ◽  
Α Subunit ◽  
Biochemical Evidence ◽  
Kinase Ck2

scholarly journals Disruption of the Regulatory β Subunit of Protein Kinase CK2 in Mice Leads to a Cell-Autonomous Defect and Early Embryonic Lethality

2003 ◽  
Vol 23 (3) ◽  
pp. 908-915 ◽  
Author(s):  
Thierry Buchou ◽  
Muriel Vernet ◽  
Olivier Blond ◽  
Hans H. Jensen ◽  
Hervé Pointu ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Es Cells ◽  
Single Gene ◽  
Embryonic Stem ◽  
Conditional Knockout ◽  
Yeast Cells ◽  
Β Subunit ◽  
Kinase Ck2

ABSTRACT Protein kinase CK2 is a ubiquitous protein kinase implicated in proliferation and cell survival. Its regulatory β subunit, CK2β, which is encoded by a single gene in mammals, has been suspected of regulating other protein kinases. In this work, we show that knockout of the CK2β gene in mice leads to postimplantation lethality. Mutant embryos were reduced in size at embryonic day 6.5 (E6.5). They did not exhibit signs of apoptosis but did show reduced cell proliferation. Mutant embryos were resorbed at E7.5. In vitro, CK2β−/− morula development stopped after the blastocyst stage. Attempts to generate homozygous embryonic stem (ES) cells failed. By using a conditional knockout approach, we show that lack of CK2β is deleterious for mouse ES cells and primary embryonic fibroblasts. This is in contrast to what occurs with yeast cells, which can survive without functional CK2β. Thus, our study demonstrates that in mammals, CK2β is essential for viability at the cellular level, possibly because it acquired new functions during evolution.

HIV-1 Rev transactivator: A β-subunit directed substrate and effector of protein kinase CK2

2001 ◽  
pp. 145-151
Author(s):  
Flavio Meggio ◽  
Oriano Marin ◽  
Marco Boschetti ◽  
Stefania Sarno ◽  
Lorenzo A. Pinna
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Β Subunit ◽  
Kinase Ck2 ◽  
Hiv 1
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