Insulin Analogues with Modifications at Position B26. Divergence of Binding Affinity and Biological Activity†

Biochemistry ◽  
2008 ◽  
Vol 47 (21) ◽  
pp. 5858-5868 ◽  
Author(s):  
Lenka Žáková ◽  
Ludmila Kazdová ◽  
Ivona Hančlová ◽  
Eva Protivínská ◽  
Miloslav Šanda ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Affinity ◽  
Insulin Analogues

Binding affinity and biological activity of gonadotropin-releasing hormone analogs in the African catfish, Clarias gariepinus

Aquaculture ◽  
1988 ◽  
Vol 71 (1-2) ◽  
pp. 119-131 ◽  
Author(s):  
R. De Leeuw ◽  
C. Van 't Veer ◽  
W. Smit-Van Dijk ◽  
H.J.Th. Goos ◽  
P.G.W.J. Van Oordt
Keyword(s):  
Biological Activity ◽  
Binding Affinity ◽  
Clarias Gariepinus ◽  
Gonadotropin Releasing Hormone ◽  
African Catfish ◽  
Releasing Hormone ◽  
Hormone Analogs

scholarly journals Endothelin receptor binding affinity and biological activity of a novel endothelin analog, KET-023.

1991 ◽  
Vol 55 ◽  
pp. 269
Author(s):  
Hirpkazu Akiyama ◽  
Ypghimasa Inagaki ◽  
Tomoko Kashiwabara ◽  
Hideo Ohta ◽  
Akihito Morita ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Affinity ◽  
Receptor Binding ◽  
Endothelin Receptor ◽  
Receptor Binding Affinity

scholarly journals Receptor binding affinity and biological activity of varied length of peptides elongated from C-terminal of endothelin

1990 ◽  
Vol 52 ◽  
pp. 203
Author(s):  
Hirokazu Akiyama ◽  
Yoshimasa Inagaki ◽  
Hideo Ohta ◽  
Tomoko Kashiwabara ◽  
Akihiro Iwamatsu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Affinity ◽  
Receptor Binding ◽  
Receptor Binding Affinity

scholarly journals The effect of incorporating carboxylic acid functionalities into 2,2′-bipyridine on the biological activity of the complexes formed: synthesis, structure, DNA/protein interaction, antioxidant activity and cytotoxicity

RSC Advances ◽  
2017 ◽  
Vol 7 (27) ◽  
pp. 16428-16443 ◽  
Author(s):  
Thangavel Sathiya Kamatchi ◽  
Nataraj Chitrapriya ◽  
Sarvana Loganthan Ashok Kumar ◽  
Jang Yoon Jung ◽  
Horst Puschmann ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Carboxylic Acid ◽  
Protein Binding ◽  
Binding Affinity ◽  
Protein Interaction ◽  
Acid Group ◽  
Carboxylic Acid Group ◽  
Dna Protein Interaction

Incorporation of carboxylic acid group in the bipyridine moiety has resulted in showing differences in DNA/protein binding affinity, efficiency in antioxidant activity and cytotoxicity.

Divergence of the in vitro biological activity and receptor binding affinity of a synthetic insulin analog. [21-Asparaginamide-A]insulin

Biochemistry ◽  
1980 ◽  
Vol 19 (20) ◽  
pp. 4547-4556 ◽  
Author(s):  
G. Thompson Burke ◽  
Jacob D. Chanley ◽  
Yoshio Okada ◽  
Alexandros Cosmatos ◽  
Nicolaos Ferderigos ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Affinity ◽  
Receptor Binding ◽  
Insulin Analog ◽  
Receptor Binding Affinity

Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives

2020 ◽  
Vol 17 ◽  
Author(s):  
Subramaniyan Arulmurugan ◽  
Helen P. Kavitha ◽  
Jasmine P. Vennila
Keyword(s):  
Biological Activity ◽  
Pharmaceutical Industry ◽  
Reverse Transcriptase ◽  
Binding Affinity ◽  
Biological Activities ◽  
Transcriptase Inhibitor ◽  
Synthetic Methods ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1 ◽  
Insecticidal Activities

Abstract:: Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, antiallergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired new efforts to find new derivatives with improved biological activity and different applications in the pharmaceutical industry. Outstanding the relevance of this structure, the purpose of this analysis is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity of benzoxazoles.

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