Equilibrium Unfolding of the Dimeric SAM Domain of MAPKKK Ste11 from the Budding Yeast:  Role of the Interfacial Residues in Structural Stability and Binding†

Biochemistry ◽  
2008 ◽  
Vol 47 (2) ◽  
pp. 651-659 ◽  
Author(s):  
Anirban Bhunia ◽  
Prerna N. Domadia ◽  
Xiaolong Xu ◽  
Richard Gingras ◽  
Feng Ni ◽  
...  
2021 ◽  
Vol 866 ◽  
pp. 158982
Author(s):  
Sourabh Wajhal ◽  
S.K. Mishra ◽  
A.B. Shinde ◽  
P.S.R. Krishna ◽  
R. Mittal

Geoderma ◽  
2001 ◽  
Vol 101 (3-4) ◽  
pp. 15-30 ◽  
Author(s):  
O Malam Issa ◽  
Y Le Bissonnais ◽  
C Défarge ◽  
J Trichet

2005 ◽  
Vol 280 (15) ◽  
pp. 14499-14506 ◽  
Author(s):  
Simone Schmitt ◽  
Uwe Ahting ◽  
Lutz Eichacker ◽  
Bernhard Granvogl ◽  
Nancy E. Go ◽  
...  

2011 ◽  
Vol 8 (61) ◽  
pp. 1128-1141 ◽  
Author(s):  
P. K. Vinod ◽  
Paula Freire ◽  
Ahmed Rattani ◽  
Andrea Ciliberto ◽  
Frank Uhlmann ◽  
...  

The operating principles of complex regulatory networks are best understood with the help of mathematical modelling rather than by intuitive reasoning. Hereby, we study the dynamics of the mitotic exit (ME) control system in budding yeast by further developing the Queralt's model. A comprehensive systems view of the network regulating ME is provided based on classical experiments in the literature. In this picture, Cdc20–APC is a critical node controlling both cyclin (Clb2 and Clb5) and phosphatase (Cdc14) branches of the regulatory network. On the basis of experimental situations ranging from single to quintuple mutants, the kinetic parameters of the network are estimated. Numerical analysis of the model quantifies the dependence of ME control on the proteolytic and non-proteolytic functions of separase. We show that the requirement of the non-proteolytic function of separase for ME depends on cyclin-dependent kinase activity. The model is also used for the systematic analysis of the recently discovered Cdc14 endocycles. The significance of Cdc14 endocycles in eukaryotic cell cycle control is discussed as well.


Nature ◽  
10.1038/32695 ◽  
1998 ◽  
Vol 392 (6673) ◽  
pp. 303-306 ◽  
Author(s):  
Masaki Mizunuma ◽  
Dai Hirata ◽  
Kohji Miyahara ◽  
Eiko Tsuchiya ◽  
Tokichi Miyakawa
Keyword(s):  

2020 ◽  
Vol 12 (25) ◽  
pp. 28416-28425 ◽  
Author(s):  
Adara Babuji ◽  
Inés Temiño ◽  
Ana Pérez-Rodríguez ◽  
Olga Solomeshch ◽  
Nir Tessler ◽  
...  

2020 ◽  
Vol 118 (3) ◽  
pp. 181a-182a
Author(s):  
Christine Dunham ◽  
Eric D. Hoffer ◽  
Ha An Nguyen ◽  
Sunita Subramanian ◽  
Samuel Hong ◽  
...  

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