scholarly journals Analysis of Binding Interactions of Pepsin Inhibitor-3 To Mammalian and Malarial Aspartic Proteases†

Biochemistry ◽  
2007 ◽  
Vol 46 (49) ◽  
pp. 14198-14205 ◽  
Author(s):  
Rebecca E. Moose ◽  
José C. Clemente ◽  
Larry R. Jackson ◽  
Minh Ngo ◽  
Kimberly Wooten ◽  
...  
Keyword(s):  
Aspartic Proteases ◽  
Binding Interactions ◽  
Pepsin Inhibitor

scholarly journals Binding Interactions of Peptide Aptamers

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6055
Author(s):  
Roger R. C. New ◽  
Tam T. T. Bui ◽  
Michal Bogus
Keyword(s):  
Amino Acid ◽  
Binding Site ◽  
Cyclic Peptides ◽  
Binding Interactions ◽  
Peptide Aptamers ◽  
Linear Peptide ◽  
Signalling Molecules ◽  
Antibody Binding Site ◽  
Linear Chains ◽  
Protein Receptors

Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops located on the surface of protein receptors (e.g., GCPR), which take part in cell-to-cell communications either directly or via the intermediary of hormones or signalling molecules. To confer on aptamers the same sort of conformational rigidity that characterises an antibody binding site, aptamers are often constructed in the form of cyclic peptides, on the assumption that this will encourage stronger binding interactions than would occur if the aptamers were simply linear chains. However, no formal studies have been conducted to confirm the hypothesis that linear peptides will engage in stronger binding interactions with cyclic peptides than with other linear peptides. In this study, the interaction of a model cyclic decamer with a series of linear peptide constructs was compared with that of a linear peptide with the same sequence, showing that the cyclic configuration does confer benefits by increasing the strength of binding.

scholarly journals Hydroxyl Groups on Annular Ring-B Dictate the Affinities of Flavonol–CCL2 Chemokine Binding Interactions

ACS Omega ◽  
2021 ◽  
Author(s):  
Nidhi Joshi ◽  
Deepak Kumar Tripathi ◽  
Nupur Nagar ◽  
Krishna Mohan Poluri
Keyword(s):  
Hydroxyl Groups ◽  
Binding Interactions ◽  
Annular Ring

scholarly journals Emergent synthetic methods for the modular advancement of sp3-rich fragments

2021 ◽  
Vol 12 (13) ◽  
pp. 4646-4660
Author(s):  
Max J. Caplin ◽  
Daniel J. Foley
Keyword(s):  
Synthetic Methods ◽  
Binding Interactions ◽  
Target Binding

This Perspective reviews recently developed methods that are likely to be of value to the elaboration of sp3-rich fragments from carbon-centred vectors, whilst maintaining key fragment-to-target binding interactions.

scholarly journals Protein folding stability and binding interactions through the lens of evolution: a dynamical perspective

2021 ◽  
Vol 66 ◽  
pp. 207-215
Author(s):  
Tushar Modi ◽  
Paul Campitelli ◽  
Ismail Can Kazan ◽  
Sefika Banu Ozkan
Keyword(s):  
Protein Folding ◽  
Binding Interactions

scholarly journals Mechanism of binding interactions between young apple polyphenols and porcine pancreatic α-amylase

2019 ◽  
Vol 283 ◽  
pp. 468-474 ◽  
Author(s):  
Lijun Sun ◽  
Frederick J. Warren ◽  
Michael J. Gidley ◽  
Yurong Guo ◽  
Ming Miao
Keyword(s):  
Binding Interactions ◽  
Young Apple
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