Use of a Chemical Genetic Technique To Identify Myosin IIB as a Substrate of the Abl-Related Gene (Arg) Tyrosine Kinase

Biochemistry ◽  
2007 ◽  
Vol 46 (41) ◽  
pp. 11614-11620 ◽  
Author(s):  
Scott N. Boyle ◽  
Anthony J. Koleske
Keyword(s):  
Tyrosine Kinase ◽  
Related Gene ◽  
Chemical Genetic ◽  
Genetic Technique ◽  
Arg Tyrosine Kinase

scholarly journals The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress

2001 ◽  
Vol 276 (15) ◽  
pp. 11465-11468 ◽  
Author(s):  
Cheng Cao ◽  
Xinping Ren ◽  
Surender Kharbanda ◽  
Anthony Koleske ◽  
K. V. S. Prasad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tyrosine Kinase ◽  
Cell Signaling ◽  
Tyrosine Kinases ◽  
Functional Significance ◽  
Related Gene ◽  
Apoptotic Response ◽  
Arg Tyrosine Kinase ◽  
Nonreceptor Tyrosine Kinases ◽  
Dependent Mechanism

The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and ARG (Abl-related gene). Certain insights are available regarding the involvement c-Abl in the response of cells to stress. ARG, however, has no known function in cell signaling. The present studies demonstrate that ARG associates with the proapoptotic Siva-1 protein. The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr48. The proapoptotic effects of Siva-1 are accentuated in cells stably expressing ARG and are inhibited in ARG-deficient cells. Moreover, the proapoptotic effects of Siva-1 are abrogated by mutation of the Tyr48site. We also show that the apoptotic response to oxidative stress is attenuated in ARG-deficient cells and that this defect is corrected by reconstituting ARG expression. These findings support a model in which the activation of ARG by oxidative stress induces apoptosis by a Siva-1-dependent mechanism.

scholarly journals Regulation of Actin Polymerization and Adhesion-Dependent Cell Edge Protrusion by the Abl-Related Gene (Arg) Tyrosine Kinase and N-WASp

Biochemistry ◽  
2010 ◽  
Vol 49 (10) ◽  
pp. 2227-2234 ◽  
Author(s):  
Matthew M. Miller ◽  
Stefanie Lapetina ◽  
Stacey M. MacGrath ◽  
Mindan K. Sfakianos ◽  
Thomas D. Pollard ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Actin Polymerization ◽  
Related Gene ◽  
Cell Edge ◽  
Dependent Cell ◽  
Arg Tyrosine Kinase

scholarly journals The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.

2012 ◽  
Vol 287 (43) ◽  
pp. 36527-36527
Author(s):  
Cheng Cao ◽  
Xingping Ren ◽  
Surender Kharbanda ◽  
Anthony J. Koleske ◽  
K. V. S. Prasad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tyrosine Kinase ◽  
Apoptotic Response ◽  
Arg Tyrosine Kinase

Correction: Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions (doi:10.1242/jcs.183640)

2019 ◽  
Vol 132 (19) ◽  
pp. jcs238832
Author(s):  
Barbara Torsello ◽  
Cristina Bianchi ◽  
Chiara Meregalli ◽  
Vitalba Di Stefano ◽  
Lara Invernizzi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
High Glucose ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Arg Tyrosine Kinase ◽  
Renal Tubular ◽  
Tgf Β1

Protein tyrosine kinase 7: a hepatocellular carcinoma-related gene detected by triple-combination array

2015 ◽  
Vol 195 (2) ◽  
pp. 444-453 ◽  
Author(s):  
Mitsuhiro Hishida ◽  
Yoshikuni Inokawa ◽  
Nao Takano ◽  
Yoko Nishikawa ◽  
Naoki Iwata ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Triple Combination ◽  
Related Gene ◽  
Protein Tyrosine ◽  
Protein Tyrosine Kinase 7

scholarly journals ABL2/ARG Tyrosine Kinase Mediates SEMA3F-induced RhoA Inactivation and Cytoskeleton Collapse in Human Glioma Cells

2008 ◽  
Vol 283 (40) ◽  
pp. 27230-27238 ◽  
Author(s):  
Akio Shimizu ◽  
Akiko Mammoto ◽  
Joseph E. Italiano ◽  
Elke Pravda ◽  
Andrew C. Dudley ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Arg Tyrosine Kinase

The Tyrosine Kinase Abl-Related Gene ARG Is Fused toETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts

Blood ◽  
1999 ◽  
Vol 94 (12) ◽  
pp. 4370-4373 ◽  
Author(s):  
Giovanni Cazzaniga ◽  
Sabrina Tosi ◽  
Alessandra Aloisi ◽  
Giovanni Giudici ◽  
Maria Daniotti ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Chimeric Protein ◽  
Fusion Transcript ◽  
Related Gene ◽  
Chain Reaction ◽  
Nonreceptor Tyrosine Kinase ◽  
Polymerase Chain ◽  
Rapid Amplification

Abstract The Ets variant gene 6 (ETV6/TEL) gene is rearranged in the majority of patients with 12p13 translocations fused to a number of different partners. We present here a case of acute myeloid leukemia M4 with eosinophilia (AML-M4Eo) positive for the CBFb/MYH11 rearrangement and carrying a t(1;12)(q25;p13) that involves the ETV6 gene at 12p13. By 3′rapid amplification of cDNA ends-polymerase chain reaction (3′RACE-PCR), a novel fusion transcript was identified between the ETV6 and the Abelson-related gene (ARG) at 1q25, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase (PTK) domains of ARG. The reciprocal transcript ARG-ETV6 was also detected in the patient RNA by reverse transcriptase-polymerase chain reaction (RT-PCR), although at a lower expression level. The ARG gene encodes for a nonreceptor tyrosine kinase characterized by high homology with c-Abl in the TK, SH2, and SH3 domains. This is the first report on ARGinvolvement in a human malignancy.

scholarly journals Arg tyrosine kinase is involved in homologous recombinational DNA repair

2002 ◽  
Vol 299 (5) ◽  
pp. 697-702 ◽  
Author(s):  
Yingzhu Li ◽  
Hiroko Shimizu ◽  
Shuang-Lin Xiang ◽  
Yoshiro Maru ◽  
Noriaki Takao ◽  
...  
Keyword(s):  
Dna Repair ◽  
Tyrosine Kinase ◽  
Arg Tyrosine Kinase ◽  
Recombinational Dna Repair

scholarly journals Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress

Oncogene ◽  
2005 ◽  
Vol 24 (15) ◽  
pp. 2433-2440 ◽  
Author(s):  
Cheng Cao ◽  
Yanping Li ◽  
Yumei Leng ◽  
Ping Li ◽  
Qingjun Ma ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tyrosine Kinase ◽  
Arg Tyrosine Kinase

scholarly journals Retraction: Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions

2020 ◽  
Vol 133 (20) ◽  
pp. jcs254847
Author(s):  
Barbara Torsello ◽  
Cristina Bianchi ◽  
Chiara Meregalli ◽  
Vitalba Di Stefano ◽  
Lara Invernizzi ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
High Glucose ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Arg Tyrosine Kinase ◽  
Renal Tubular ◽  
Tgf Β1
Sign in / Sign up

Export Citation Format

Share Document