Physical and Functional Interactions between Liver X Receptor/Retinoid X Receptor and Sp1 Modulate the Transcriptional Induction of the Human ATP Binding Cassette Transporter A1 Gene by Oxysterols and Retinoids†

Biochemistry ◽  
2007 ◽  
Vol 46 (41) ◽  
pp. 11473-11483 ◽  
Author(s):  
Efstathia Thymiakou ◽  
Vassilis I. Zannis ◽  
Dimitris Kardassis
Keyword(s):  
Liver X Receptor ◽  
Retinoid X Receptor ◽  
Atp Binding ◽  
Functional Interactions ◽  
Atp Binding Cassette Transporter ◽  
Transcriptional Induction ◽  
Atp Binding Cassette

scholarly journals Dichlorodiphenyltrichloroethane Impairs Amyloid Beta Clearance by Decreasing Liver X Receptor α Expression

2021 ◽  
Vol 13 ◽  
Author(s):  
Dongmei Wu ◽  
Yang Hu ◽  
Min Song ◽  
Gongbo Li
Keyword(s):  
Amyloid Beta ◽  
Critical Role ◽  
Liver X Receptor ◽  
Dynamics Simulation ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Liver X Receptor Α ◽  
Aβ Clearance ◽  
Atp Binding Cassette

Abnormal amyloid beta (Aβ) clearance is a distinctive pathological mechanism for Alzheimer’s disease (AD). ATP-binding cassette transporter A1 (ABCA1), which mediates the lipidation of apolipoprotein E, plays a critical role in Aβ clearance. As an environmental factor for AD, dichlorodiphenyltrichloroethane (DDT) can decrease ATP-binding cassette transporter A1 (ABCA1) expression and disrupt Aβ clearance. Liver X receptor α (LXRα) is an autoregulatory transcription factor for ABCA1 and a target of some environmental pollutants, such as organophosphate pesticides. In this study, we aimed to investigate whether DDT could affect Aβ clearance by targeting LXRα. The DDT-pretreated H4 human neuroglioma cells and immortalized astrocytes were incubated with exogenous Aβ to evaluate Aβ consumption. Meanwhile, cytotoxicity and LXRα expression were determined in the DDT-treated cells. Subsequently, the antagonism of DDT on LXRα agonist T0901317 was determined in vitro. The interaction between DDT and LXRα was predicted by molecular docking and molecular dynamics simulation technology. We observed that DDT could inhibit Aβ clearance and decrease the levels of LXRα mRNA and LXRα protein. Moreover, DDT is supposed to strongly bind to LXRα and exert antagonistic effects on LXRα. In conclusion, this study firstly presented that DDT could inhibit LXRα expression, which would contribute to Aβ clearance decline in vitro. It provides an experimental basis to search for potential therapeutic targets of AD.

scholarly journals Stimulation of the Liver X Receptor Pathway Inhibits HIV-1 Replication via Induction of ATP-Binding Cassette Transporter A1

2010 ◽  
Vol 78 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Matthew P. Morrow ◽  
Angela Grant ◽  
Zahedi Mujawar ◽  
Larisa Dubrovsky ◽  
Tatiana Pushkarsky ◽  
...  
Keyword(s):  
Liver X Receptor ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Hiv 1 ◽  
Stimulation Of ◽  
Atp Binding Cassette
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